DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment rec and MCM4

DIOPT Version :9

Sequence 1:NP_001262615.1 Gene:rec / 49241 FlyBaseID:FBgn0003227 Length:885 Species:Drosophila melanogaster
Sequence 2:NP_005905.2 Gene:MCM4 / 4173 HGNCID:6947 Length:863 Species:Homo sapiens


Alignment Length:904 Identity:203/904 - (22%)
Similarity:355/904 - (39%) Gaps:246/904 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 SRGGAPSRFVRGRGRGGGAYRPYF-------YFRRNGRVIPAGGNRQPNQGEPG----APDAPSV 59
            |....|||....|||...|..|..       ..||.|....:.|..||....||    :|.|..|
Human     3 SPASTPSRRGSRRGRATPAQTPRSEDARSSPSQRRRGEDSTSTGELQPMPTSPGVDLQSPAAQDV 67

  Fly    60 ----PPATRQPRGWSRTAGKRGRNAHLDCSFLRPENYAAPEDGLQVQSIAVDNPRAYSGWRLYFL 120
                ||......            ..||.....|..|..|...::      ..||  ||.|...:
Human    68 LFSSPPQMHSSA------------IPLDFDVSSPLTYGTPSSRVE------GTPR--SGVRGTPV 112

  Fly   121 REKYEEGN-------------ELATRIMAVE----------------AYYQRNPHTFDFVMIRDR 156
            |::.:.|:             ..|..|:|.|                |..:.|     |.....|
Human   113 RQRPDLGSAQKGLQVDLQSDGAAAEDIVASEQSLGQKLVIWGTDVNVAACKEN-----FQRFLQR 172

  Fly   157 GFFPLCAAGIKSDAQLKEVWPSLSEDIREHPL--RTLGTLSLAMHTVVVNHQLDCNDSTT----- 214
            ...||        |:.:|   ::..||.| ||  :.||.:::.....:   .::|....:     
Human   173 FIDPL--------AKEEE---NVGIDITE-PLYMQRLGEINVIGEPFL---NVNCEHIKSFDKNL 222

  Fly   215 --AMVSTPEQYVLPT--PRVRKIY--------------ARPDDFVPVESIEGISHSRVDTLFSIR 261
              .::|.|:: |:||  ..|.:|:              .||.:.:..:::..::...:|.|.:|.
Human   223 YRQLISYPQE-VIPTFDMAVNEIFFDRYPDSILEHQIQVRPFNALKTKNMRNLNPEDIDQLITIS 286

  Fly   262 GFVSNVGEPSYSLTWQAFRCSRC----QMEIAMRQRGTFQPRPYQCKRSECVARDEFVPLRSSPY 322
            |.|....:....:....|:|..|    ::|:   .||.. ..|..|.|.........:..||   
Human   287 GMVIRTSQLIPEMQEAFFQCQVCAHTTRVEM---DRGRI-AEPSVCGRCHTTHSMALIHNRS--- 344

  Fly   323 TRLSIRQIIRVEESSLNLVHDFETSMPA-----EMDVELRHDLVDAVRVGQEVVVTGILKLQELG 382
             ..|.:|:|:::||        ...|||     .:.:...:||||.|:.|..|.||||.:...:.
Human   345 -LFSDKQMIKLQES--------PEDMPAGQTPHTVILFAHNDLVDKVQPGDRVNVTGIYRAVPIR 400

  Fly   383 DDTTTGDTSNQMQPYLKAVSIR----------DASSIKREFSERDLEAIVMINAEPNSFKLLVQS 437
            .:....:..:..:.::..:..|          |..:.::.|||:.:|.:..::.:|:.::.|..:
Human   401 VNPRVSNVKSVYKTHIDVIHYRKTDAKRLHGLDEEAEQKLFSEKRVELLKELSRKPDIYERLASA 465

  Fly   438 IAPEVYGHELPKAACLLSLLG---------GKGAETEAINVLLVGDPGIGKTKILQSCAQIAERG 493
            :||.:|.||..|...||.|.|         |:|.....||:||.||||..|:::||....:..||
Human   466 LAPSIYEHEDIKKGILLQLFGGTRKDFSHTGRGKFRAEINILLCGDPGTSKSQLLQYVYNLVPRG 530

  Fly   494 AHVSGKRGAQSAQQLGVTF-----AGRNKRVLQAGSLMMASGGGHCTLDDVDKL-ASKQAVLLQC 552
            .:.|||    .:..:|:|.     ....:.|||.|:|:: |..|.|.:|:.||: .|.::||.:.
Human   531 QYTSGK----GSSAVGLTAYVMKDPETRQLVLQTGALVL-SDNGICCIDEFDKMNESTRSVLHEV 590

  Fly   553 LQSEEVNLPLAGAFASFPAQPSVIACANPQRGQYDEGRYLLQNINISPSLLREFHLVYILLDKPS 617
            ::.:.:::..||......|:.||:|.|||...|::..:..::||.:..:||..|.|:::|||...
Human   591 MEQQTLSIAKAGIICQLNARTSVLAAANPIESQWNPKKTTIENIQLPHTLLSRFDLIFLLLDPQD 655

  Fly   618 ER-DMSLTAHVRALHAGARKRARIAARYALKPKMSDSMCEVSLNVPAAGKDDDTIKTEDDNDSIM 681
            |. |..|..|:.||:                                                  
Human   656 EAYDRRLAHHLVALY-------------------------------------------------- 670

  Fly   682 QQDYDLDKRLEVLPEEGDLDLLPPILIKKFLSYARQELNPVLNEDASNAVLRYFLELKGSCNLDE 746
               |..:       |:.:.:||...::|.:::||...:.|.|:|:||.|::..:::::       
Human   671 ---YQSE-------EQAEEELLDMAVLKDYIAYAHSTIMPRLSEEASQALIEAYVDMR------- 718

  Fly   747 DVSSQIGAG---------QLLAIIHLSQARARLDLSHVVSPQHVRDVIALLTESITQTS 796
                :||:.         ||.::|.|::|.|::.||:.|....|.:...|..|::.|::
Human   719 ----KIGSSRGMVSAYPRQLESLIRLAEAHAKVRLSNKVEAIDVEEAKRLHREALKQSA 773

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
recNP_001262615.1 RNR_PFL <117..200 CDD:299130 21/113 (19%)
MCM 243..792 CDD:214631 139/592 (23%)
P-loop_NTPase 468..606 CDD:304359 45/143 (31%)
MCM4NP_005905.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..60 17/56 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 91..126 9/42 (21%)
MCM_N 163..263 CDD:405270 23/120 (19%)
MCM 267..770 CDD:214631 139/594 (23%)
Arginine finger 642..645 0/2 (0%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1241
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D232729at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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