Protein Alignment rec and MCM3

DIOPT Version :10

• Sequence 1: NP_732072.1
• Gene: rec / 49241
• FlyBaseID: FBgn0003227
• Length: 885
• Species: Drosophila melanogaster
• Sequence 2: NP_001353298.1
• Gene: MCM3 / 4172
• HGNCID: 6945
• Length: 833
• Species: Homo sapiens
• Alignment Length: 683
• Identity: 154/683 - (22%)
• Similarity: 277/683 - (40%)
• Gaps: 155/683 - (22%)

  Fly   239 DFVPVESIEGISHSRVDTLFS--------------------------------------IRGFVS 265
            ||:..|..:||..|:|..|.|                                      ::.||:
Human    21 DFLDDEEDQGIYQSKVRELISDNQYRLIVNVNDLRRKNEKRANRLLNNAFEELVAFQRALKDFVA 85

  Fly   266 NVGEPSYSLTWQAFRCSRCQMEIAMRQRGTF-----QPRPYQCKRSECVARDEFVPLRSS----- 320
            :: :.:|:..::         |..:...|:|     .||........||...|.:..:.|
Human    86 SI-DATYAKQYE---------EFYVGLEGSFGSKHVSPRTLTSCFLSCVVCVEGIVTKCSLVRPK 140

  Fly   321 --------PYTRLSIRQ-------IIRVEESS-----------------LNLVHDFET------- 346
                    |.|:.:|.:       ::....||                 |::..|.:|
Human   141 VVRSVHYCPATKKTIERRYSDLTTLVAFPSSSVYPTKDEENNPLETEYGLSVYKDHQTITIQEMP 205

  Fly   347 ------SMPAEMDVELRHDLVDAVRVGQEVVVTGILKLQELGDDTTTGDTSNQMQPYLKAVSIRD 405
                  .:|..:||.|..||||..:.|..|.|.|..:..   .....|.||...:..|.|.:::.
Human   206 EKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVVGTYRCL---PGKKGGYTSGTFRTVLIACNVKQ 267

  Fly   406 AS-SIKREFSERDLEAIVMIN--AEPNSFKLLVQSIAPEVYGHELPKAACLLSLLGGKGAETE-- 465
            .| ..:..||..|:..|...:  ...:.|..|.:|:||.::||:..|.|.|..||||...:.|
Human   268 MSKDAQPSFSAEDIAKIKKFSKTRSKDIFDQLAKSLAPSIHGHDYVKKAILCLLLGGVERDLENG 332

  Fly   466 -----AINVLLVGDPGIGKTKILQSCAQIAERGAHVSGKRGAQSAQQLGVTFA-----GRNKRVL 520
                 .||:||:|||.:.|:::|:.....|.|....:| ||:..   :|:|.|     ...:|.|
Human   333 SHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTG-RGSSG---VGLTAAVTTDQETGERRL 393

  Fly   521 QAGSLMMASGGGHCTLDDVDKLAS-KQAVLLQCLQSEEVNLPLAGAFASFPAQPSVIACANPQRG 584
            :||::::|..|..| :|:.||::. .:..:.:.::...|.:..||..|...|:.||:|.|||..|
Human   394 EAGAMVLADRGVVC-IDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYG 457

  Fly   585 QYDEGRYLLQNINISPSLLREFHLVYILLDK-PSERDMSLTAHVRALHAGARKRARIAARYALKP 648
            :||:.:..::||.:..|||..|.|::|:||: ..|:|..::.||..:|           ||....
Human   458 RYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMH-----------RYRAPG 511

  Fly   649 KMSDSMCEVSLNVPAAGKDDDTIKTEDDNDSIMQQDYD-----LDKRLEVLPEEGDLDLLPPILI 708
            :.......:...|.....||.....||..|:.:.:.:|     ..|:.|        .::....:
Human   512 EQDGDAMPLGSAVDILATDDPNFSQEDQQDTQIYEKHDNLLHGTKKKKE--------KMVSAAFM 568

  Fly   709 KKFLSYARQELNPVLNEDASNAVLRYFLELKGSCNLDEDV--SSQIGAGQLLAIIHLSQARARLD 771
            ||::..|: .:.|||.::::..:...:..|:...::..|.  :|.:.|..|..:|.|:.|.|:..
Human   569 KKYIHVAK-IIKPVLTQESATYIAEEYSRLRSQDSMSSDTARTSPVTARTLETLIRLATAHAKAR 632

  Fly   772 LSHVVSPQHVRDVIALLTESITQTSLKEGSSRQ 804
            :|..|..|...:.:.|:..:..:..|::...|:
Human   633 MSKTVDLQDAEEAVELVQYAYFKKVLEKEKKRK 665

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rec	NP_732072.1	Mcm2	177..799	CDD:440854	153/676 (23%)
		MCM8	433..791	CDD:350665	100/378 (26%)
		MCM8_WHD	819..883	CDD:439328
MCM3	NP_001353298.1	MCM_N	16..104	CDD:464206	13/92 (14%)
		MCM	109..654	CDD:214631	137/572 (24%)
		Arginine finger	477..480		0/2 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	662..739		1/4 (25%)