DRSC/TRiP Functional Genomics Resources

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Protein Alignment rec and MCM2

DIOPT Version :10

Sequence 1:NP_732072.1 Gene:rec / 49241 FlyBaseID:FBgn0003227 Length:885 Species:Drosophila melanogaster
Sequence 2:NP_004517.2 Gene:MCM2 / 4171 HGNCID:6944 Length:904 Species:Homo sapiens


Alignment Length:845 Identity:183/845 - (21%)
Similarity:333/845 - (39%) Gaps:198/845 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 TLSRGGAPSRFVRGR----GRGGGAYRPYFYF--RRNGRVIPAGGNRQPNQG-EPGAPDAPSVPP 61
            |.|:..|..|.:|.|    |||.|..|....:  .......||...||..:. |.|..|...:..
Human   106 TASQREAAERAMRQRDREAGRGLGRMRRGLLYDSDEEDEERPARKRRQVERATEDGEEDEEMIES 170

  Fly    62 AT-------RQPRGWSRTAGKRGRNAHLDCSFLRP--ENYAAPEDGLQVQSIAVDNPRAYSGWRL 117
            ..       ...|.|...||.|....|...:|||.  :::.......::..:..:|..:      
Human   171 IENLEDLKGHSVREWVSMAGPRLEIHHRFKNFLRTHVDSHGHNVFKERISDMCKENRES------ 229

  Fly   118 YFLREKYEEGNELATRIMAVEAYYQRNPHTFDFVMIRDRGFFPLCAAGIKSDAQLKEVWPSLSED 182
              |...||   :||.|           .|...:       |.|      ::.|:|.:::...:.:
Human   230 --LVVNYE---DLAAR-----------EHVLAY-------FLP------EAPAELLQIFDEAALE 265

  Fly   183 IREHPLRTLGTLSLAMHTV---VVNHQLDCNDSTTAMVSTPEQYVLPTPRVRKIYARPDDFVPVE 244
            :           .|||:..   :.||                           |:.|......||
Human   266 V-----------VLAMYPKYDRITNH---------------------------IHVRISHLPLVE 292

  Fly   245 SIEGISHSRVDTLFSIRGFVSNVGEPSYSLTWQAFRCSRCQMEIAMRQRGTF------QPRPYQC 303
            .:..:....::.|....|.|::.......|:...:.|::|...:     |.|      :.:|..|
Human   293 ELRSLRQLHLNQLIRTSGVVTSCTGVLPQLSMVKYNCNKCNFVL-----GPFCQSQNQEVKPGSC 352

  Fly   304 KRSECVARDEF-VPLRSSPYTRLSIRQIIRVEESSLNLVHDFETSMPAEMDVELRHDLVDAVRVG 367
              .||.:...| |.:..:.|...   |.||::||...:.   ...:|...|..|..||||:.:.|
Human   353 --PECQSAGPFEVNMEETIYQNY---QRIRIQESPGKVA---AGRLPRSKDAILLADLVDSCKPG 409

  Fly   368 QEVVVTGILKLQELGDDTTTGDTSNQMQPYLKA-----VSIRDASSIKREFSERDLEAIVMINAE 427
            .|:.:|||......|    :.:|:|....:...     |:.:|......|.::.|::.|..::.:
Human   410 DEIELTGIYHNNYDG----SLNTANGFPVFATVILANHVAKKDNKVAVGELTDEDVKMITSLSKD 470

  Fly   428 PNSFKLLVQSIAPEVYGHELPKAACLLSLLGGK----GAETEA---INVLLVGDPGIGKTKILQS 485
            ....:.:..||||.:||||..|....|:|.||:    |.:.:.   |||||.||||..|::.|:.
Human   471 QQIGEKIFASIAPSIYGHEDIKRGLALALFGGEPKNPGGKHKVRGDINVLLCGDPGTAKSQFLKY 535

  Fly   486 CAQIAERGAHVSGKRGAQSAQQLGVT-FAGRN----KRVLQAGSLMMASGGGHCTLDDVDKLASK 545
            ..:::.|....:|    |.|..:|:| :..|:    :..|:||:|::|. .|.|.:|:.||:..:
Human   536 IEKVSSRAIFTTG----QGASAVGLTAYVQRHPVSREWTLEAGALVLAD-RGVCLIDEFDKMNDQ 595

  Fly   546 QAVLL-QCLQSEEVNLPLAGAFASFPAQPSVIACANPQRGQYDEGRYLLQNINISPSLLREFHLV 609
            ....: :.::.:.:::..||...|..|:.:|||.|||..|:||......:|::::..::..|.::
Human   596 DRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFSENVDLTEPIISRFDIL 660

  Fly   610 YILLD--KPSERDM----SLTAHVRALHAGARKRARIAARYALKPKMSDSMCEVSLNVPAAGKDD 668
            .::.|  .|.:.:|    .:.:|||. |...::...:|...|.:|.|.::.              
Human   661 CVVRDTVDPVQDEMLARFVVGSHVRH-HPSNKEEEGLANGSAAEPAMPNTY-------------- 710

  Fly   669 DTIKTEDDNDSIMQQDYDLDKRLEVLPEEGDLDLLPPILIKKFLSYARQELNPVLNEDASNAVLR 733
                                 .:|.||:|         ::||::.||::.::|.||:...:.|.:
Human   711 ---------------------GVEPLPQE---------VLKKYIIYAKERVHPKLNQMDQDKVAK 745

  Fly   734 YFLELKGSCNLDEDV---SSQIGAGQLLAIIHLSQARARLDLSHVVSPQHVRDVIALLTESITQT 795
            .:.:|:     .|.:   |..|....:.::|.:::|.||:.|...|....|...|.::.||...|
Human   746 MYSDLR-----KESMATGSIPITVRHIESMIRMAEAHARIHLRDYVIEDDVNMAIRVMLESFIDT 805

  Fly   796  795
            Human   806  805

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
recNP_732072.1 Mcm2 177..799 CDD:440854 144/656 (22%)
MCM8 433..791 CDD:350665 92/379 (24%)
MCM8_WHD 819..883 CDD:439328
MCM2NP_004517.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..80
Interaction with KAT7. /evidence=ECO:0000250 2..257 39/185 (21%)
Interaction with DNJC9. /evidence=ECO:0000269|PubMed:33857403 61..130 9/23 (39%)
MCM2_N 73..182 CDD:403724 18/75 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 109..167 16/57 (28%)
MCM_N 197..287 CDD:464206 23/162 (14%)
MCM 291..803 CDD:214631 136/583 (23%)
Arginine finger 655..658 0/2 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 686..705 3/19 (16%)
Blue background indicates that the domain is not in the aligned region.

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