DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rec and mcm6.2

DIOPT Version :9

Sequence 1:	NP_001262615.1	Gene:	rec / 49241	FlyBaseID:	FBgn0003227	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_989393.1	Gene:	mcm6.2 / 395030	XenbaseID:	XB-GENE-962678	Length:	823	Species:	Xenopus tropicalis

Alignment Length:	776	Identity:	175/776 - (22%)
Similarity:	311/776 - (40%)	Gaps:	197/776 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 PRVRKIYARPDDFVPVESIEGISHSRVDTLFSIRGFVSNVGEPSYSLTWQAFRCSRCQMEIAMRQ 292
            |:.::.|....|......|..::..|:.:|..|.|.|.........|....|.|..||..:...:
Frog   106 PQNKEFYVAFQDLPTRHKIRELTTPRIGSLLRISGQVVRTHPVHPELVSGTFLCLDCQTLVRDVE 170

  Fly   293 RGTFQPRPYQCKRSECVARDEFVPLRSSPYTRLSIRQIIRVEESSLNLVHDFETSMPAEMDVELR 357
            :.....:|..|:...|..|..|  :..:..:|....|.:|::|:...|...   |:|..::|.||
Frog   171 QQFKYTQPSICRNPVCANRRRF--MLDTNKSRFVDFQKVRIQETQAELPRG---SIPRSVEVILR 230

  Fly   358 HDLVDAVRVGQEVVVTGIL----KLQELGDDTTTGDTSNQM---QPY-------LKAVSIRD--- 405
            .:.|::.:.|.....||.|    .:.:|.......:||.::   :.|       |:|:.:||
Frog   231 AEAVESCQAGDRCDFTGSLIVVPDISQLATPGVRAETSARVGGTEGYQAEGVQGLRALGVRDLSY 295

  Fly   406 ---------------------------ASSIKREFSERDLEAIVMINAEPNSFKLLVQSIAPEVY 443
                                       |.|||.:.|.::.|.:..::.:.|.:..|..|:.|.|:
Frog   296 KLVFLACYVCPTNPRFGGKDLHEEDMTAESIKNQMSVKEWEKVFEMSQDKNLYHNLCTSLFPTVH 360

  Fly   444 GHELPKAACLLSLLGG------KGAETEA-INVLLVGDPGIGKTKILQSCAQIAERGAHVSGKRG 501
            |::..|...||.|.||      :|..... |||.:||||...|::.|:...:.:.|..:.|||
Frog   361 GNDEVKRGILLMLFGGVPKTTMEGTSLRGDINVCIVGDPSTAKSQFLKHVEEFSPRAVYTSGK-- 423

  Fly   502 AQSAQQLGVTFA-----GRNKRVLQAGSLMMASGGGHCTLDDVDKLASK-QAVLLQCLQSEEVNL 560
            |.||  .|:|.|     ..::.|::||:||:|. .|.|.:|:.||:.:| |..:.:.::.:.:::
Frog   424 ASSA--AGLTAAVVKDEESHEFVIEAGALMLAD-NGVCCIDEFDKMDTKDQVAIHEAMEQQTISI 485

  Fly   561 PLAGAFASFPAQPSVIACANPQRGQYDEGRYLLQNINISPSLLREFHLVYILLDKPSE-RDMSLT 624
            ..||..|:..|:.|::|.|||..|:||..:.|.||||:|..::..|.|.:||:|:.:| .|.::.
Frog   486 TKAGVKATLNARTSILAAANPVGGRYDRAKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIA 550

  Fly   625 AHVRALHAGARKRARIAARYALKPKMSDSMCEVSLNVPAAGKDDDTIKTEDDNDSIMQQDYDLDK 689
            ..:..||:                                       :.|:..|.:    |.||:
Frog   551 RRIVDLHS---------------------------------------RIEESIDRV----YTLDE 572

  Fly   690 RLEVLPEEGDLDLLPPILIKKFLSYARQELNPVLNEDASNAVLRYFLELKGSCNLDEDVSS-QIG 753
                              ::::|.:||| ..|.:::::.:.::..:..|:.........|: :|.
Frog   573 ------------------VRRYLLFARQ-FKPKISKESEDFIVEQYKRLRQRDGTGVTKSAWRIT 618

  Fly   754 AGQLLAIIHLSQARARLDLSHVVSPQHVRDVIALLTESITQTSLK-------------------- 798
            ..||.::|.||:..||:..|..|.|:||::...||.:||.:....
Frog   619 VRQLESMIRLSEGMARMHCSDEVQPKHVKEAFRLLNKSIIRVETPDVNLDQEDEHEAEEEPQEVI 683

  Fly   799 --EGSSRQGTRGG-GGAGGGA----------------GKSAQLRNFL-----------ELTKRRS 833
              :.|...|..|. .|..|.|                .:..::.|.|           |.::|:|
Frog   684 NGDASVPSGVNGHVNGMNGHAEEPNAATPKPSLRLNFAEYKRISNLLVLQLRKMEDEDETSQRKS 748

  Fly   834 AALGRRI----FEFDELKEIGTRAGI-------LTGFSQ-LVEMANLGGYLLMKGANMYEV 882
            ..:...:    .|.|..:|:.||..|       |..:.| |:|:...|    :||....||
Frog   749 ELINWYLKEIESEIDSEEELVTRKQIIDKVVHRLVHYDQILIELTQTG----LKGTGDEEV 805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rec	NP_001262615.1	RNR_PFL	<117..200	CDD:299130
		MCM	243..792	CDD:214631	144/607 (24%)
		P-loop_NTPase	468..606	CDD:304359	49/143 (34%)
mcm6.2	NP_989393.1	MCM_N	30..140	CDD:291233	7/33 (21%)
		MCM	120..658	CDD:214631	145/609 (24%)
		P-loop_NTPase	<448..535	CDD:304359	31/87 (36%)
		Arginine finger	529..532		0/2 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	666..713		6/46 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	1	1.000	-	-		FOG0001226
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920