Protein Alignment rec and mcm4

DIOPT Version :10

• Sequence 1: NP_732072.1
• Gene: rec / 49241
• FlyBaseID: FBgn0003227
• Length: 885
• Species: Drosophila melanogaster
• Sequence 2: NP_944595.2
• Gene: mcm4 / 337598
• ZFINID: ZDB-GENE-030131-9544
• Length: 845
• Species: Danio rerio
• Alignment Length: 849
• Identity: 179/849 - (21%)
• Similarity: 323/849 - (38%)
• Gaps: 237/849 - (27%)

  Fly    24 AYRPYFYFRRNGRVIPAGGNRQPNQGEPGAP-----------DAPSVPPATRQPRGWSRTAGKRG 77
            |..|..|...:.||     ...|..|..|.|           .||.|...:....|.:..||.:|
Zfish    68 ASSPLMYGTPSSRV-----EGTPRSGIRGTPARQRADLGSVRKAPQVDMHSEPASGDAAVAGDQG 127

  Fly    78 RNAHL----------DC---------SFLRPENYAAPEDGLQVQSIAVDNPRAYSGWRLYFLREK 123
            ....|          .|         .|..|::......||.     ::.|       ||.  :|
Zfish   128 AGQRLVIWGTDVNVGTCKEKFQRFLQQFTDPDSREEENAGLD-----LNEP-------LYM--QK 178

  Fly   124 YEEGNELATRIMAVEAYYQRNPHTFDFVMIRDRGFFPLCAAGIKSDAQLKEVWPSLSEDIRE--- 185
            .:|.:.:...::.|...:.:   |||..:.|....:|            :||.|:....:.|
Zfish   179 LDEISVVGEPVLNVNCTHIQ---TFDADLYRQLICYP------------QEVIPTFDMSVNELFF 228

  Fly   186 --HPLRTLGTLSLAMHTVVVNHQLDCNDSTTAMVSTPEQYVLPTPRVRKIYARPDDFVPVESIEG 248
              .|            ..|:.||                          |..||...:...::..
Zfish   229 DRFP------------DSVLEHQ--------------------------IQVRPYSAIKTRNMRN 255

  Fly   249 ISHSRVDTLFSIRGFVSNVGEPSYSLTWQAFRCSRCQMEIAMR-QRGTFQPRPYQCKRSECVARD 312
            ::...:|.|.:|.|.|....:....:....|||..|.....:. .||.. ..|..|:........
Zfish   256 LNPEDIDQLITISGMVIRTSQLIPEMQEAFFRCQVCAFNTRVEVDRGRI-AEPAVCRNCNTTHSM 319

  Fly   313 EFVPLRSSPYTRLSIRQIIRVEESSLNLVHDFETSMPAEMD-----VELRHDLVDAVRVGQEVVV 372
            ..|..||.    .|.:|:|:::||        ...|||...     |...:||||.|:.|..|.:
Zfish   320 ALVHNRSV----FSDKQMIKLQES--------PEDMPAGQTPHTTVVYAHNDLVDKVQPGDRVNI 372

  Fly   373 TGILKLQELGDDTTTGDTSNQMQPYLKAVSIR----------DASSIKREFSERDLEAIVMINAE 427
            |||.:...:..:.......:..:.::.|:..|          |....::.|::..:..:..:.|:
Zfish   373 TGIYRAAPMRLNPRQSQVKSVYKTHIDAIHFRKTDEKRLHGLDEDGEQKLFTKERVALLKELAAK 437

  Fly   428 PNSFKLLVQSIAPEVYGHELPKAACLLSLLG---------GKGAETEAINVLLVGDPGIGKTKIL 483
            |:.::.|..::||.:|.||..|...||.|.|         |:|.....:|:||.||||..|:::|
Zfish   438 PDVYERLSSALAPSIYEHEDIKKGILLQLFGGTRKDFTQTGRGNFRAEVNILLCGDPGTSKSQLL 502

  Fly   484 QSCAQIAERGAHVSGKRGAQSAQQLGVTF-----AGRNKRVLQAGSLMMASGGGHCTLDDVDKLA 543
            |....:..||.:.|||    .:..:|:|.     ....:.|||.|:|:: |..|.|.:|:.||::
Zfish   503 QYVYNLVPRGQYTSGK----GSSAVGLTAYVMKDPETRQLVLQTGALVL-SDNGICCIDEFDKMS 562

  Fly   544 -SKQAVLLQCLQSEEVNLPLAGAFASFPAQPSVIACANPQRGQYDEGRYLLQNINISPSLLREFH 607
             :.::||.:.::.:.:::..||......|:.|::|.|||...|::..:..::||.:..:||..|.
Zfish   563 DNTRSVLHEVMEQQTLSIAKAGIICQLNARTSILAAANPVESQWNPKKTTIENIQLPHTLLSRFD 627

  Fly   608 LVYILLDKPSER-DMSLTAHVRALHAGARKRARIAARYALKPKMSDSMCEVSLNVPAAGKDDDTI 671
            |::::||...|. |..|..|:.:|:
Zfish   628 LIFLMLDPQDEAYDRRLAHHLVSLY---------------------------------------- 652

  Fly   672 KTEDDNDSIMQQDYDLDKRLEVLPEEGDLDLLPPILIKKFLSYARQELNPVLNEDASNAVLRYFL 736
                         |..::::    ||..||:   .::|.::::||..::|.|:|:||.|::..::
Zfish   653 -------------YQSEEQI----EEEHLDM---AVLKDYIAFARTTVHPRLSEEASQALIEAYV 697

  Fly   737 ELKGSCNLDEDVSSQIGAG---------QLLAIIHLSQARARLDLSHVVSPQHVRDVIALLTESI 792
            :::           :||:|         ||.::|.|::|.|::..|..|....|.:...|..|::
Zfish   698 DMR-----------KIGSGRGMVSAYPRQLESLIRLAEAHAKVRFSGKVETIDVEEAKRLHREAL 751

  Fly   793 TQTS 796
            .|::
Zfish   752 KQSA 755

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rec	NP_732072.1	Mcm2	177..799	CDD:440854	144/666 (22%)
		MCM8	433..791	CDD:350665	92/382 (24%)
		MCM8_WHD	819..883	CDD:439328
mcm4	NP_944595.2	PHA03307	1..>131	CDD:223039	16/67 (24%)
		MCM_N	145..246	CDD:464206	26/167 (16%)
		MCM	249..752	CDD:214631	134/591 (23%)