DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rec and Mcm7

DIOPT Version :9

Sequence 1:	NP_001262615.1	Gene:	rec / 49241	FlyBaseID:	FBgn0003227	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_001004203.3	Gene:	Mcm7 / 288532	RGDID:	1303018	Length:	719	Species:	Rattus norvegicus

Alignment Length:	715	Identity:	168/715 - (23%)
Similarity:	303/715 - (42%)	Gaps:	139/715 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   201 VVVNHQL--DCNDSTTAMVSTPE-QYVLPTPRVRKI---YARPDDFVPVESIEGISHSRVDTLFS 259
            |.:.|:|  :........|..|: ||  |:..:|:.   :..|....| ..|..:....|..|.:
  Rat   101 VYIEHRLMMEQRSRDPGAVRNPQNQY--PSELMRRFELYFQGPSSSKP-RVIREVRADSVGKLLT 162

  Fly   260 IRGFVSNVGEPSYSLTWQAFRCSRCQMEIAMR-QRGTFQPRPYQCKRSECVARDE----FVPLRS 319
            :||.|:.|.|....:....:.|.:|..|.... |..||.|. ..|...||.....    ::..|.
  Rat   163 VRGIVTRVSEVKPRMVVATYTCDQCGAETYQPIQSPTFMPL-IMCPSQECQTNRSGGRLYLQTRG 226

  Fly   320 SPYTRLSIRQIIRVEESSLNLVHDFET---SMPAEMDVELRHDLVDAVRVGQEVVVTGIL----- 376
            |.:.:.   |.::::|      |..:.   ::|..:.|.|..:.....:.|..|.||||.
  Rat   227 SKFIKF---QEMKIQE------HSDQVPVGNIPRSITVVLEGENTRIAQPGDHVSVTGIFLPVLR 282

  Fly   377 -KLQELGDDTTTGDTSNQMQPYLKAVSIRDASSIKREFSERDLEAIVMINAEPNSFKLLVQSIAP 440
             ..|::.....: :|..:....:|.....|..|...|.|..:|:.|    ||.:.::.|..||||
  Rat   283 TGFQQMAQGLLS-ETYLEAHRVVKMTKSEDDVSGAGELSAEELKQI----AEEDFYEKLAASIAP 342

  Fly   441 EVYGHELPKAACLLSLLGGKGAETEA------INVLLVGDPGIGKTKILQSCAQIAERGAHVSGK 499
            |:||||..|.|.||.|:||.....:.      |::.|:||||:.|:::|....::|.|..:.:|
  Rat   343 EIYGHEDVKKALLLLLVGGVDQSPQGMKIRGNIHICLMGDPGVAKSQLLSYIDRLAPRSQYTTG- 406

  Fly   500 RGAQSAQQLGVTFAGRNKRV-----LQAGSLMMASGGGHCTLDDVDKLA-SKQAVLLQCLQSEEV 558
            ||:..   :|:|.|.....|     |:.|:|::|. .|.|.:|:.||:| :.:..:.:.::.:.:
  Rat   407 RGSSG---VGLTAAVLRDSVSGELTLEGGALVLAD-QGVCCIDEFDKMAEADRTAIHEVMEQQTI 467

  Fly   559 NLPLAGAFASFPAQPSVIACANPQRGQYDEGRYLLQNINISPSLLREFHLVYILLDKPS-ERDMS 622
            ::..||...:..|:.|::|.|||..|:|:..|.|.|||.:..:||..|.|::::.|:|. :.|:.
  Rat   468 SIAKAGILTTLNARCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLR 532

  Fly   623 LTAHVRALHAGARKRARIAARYALKPKMSDSMCEVSLNVPAAGKDDDTIKTEDDNDSIMQQDYDL 687
            |..|:..:|..:|:                         |.|                  |...|
  Rat   533 LAQHITYVHQHSRQ-------------------------PPA------------------QFEPL 554

  Fly   688 DKRLEVLPEEGDLDLLPPILIKKFLSYARQELNPVLNEDASNAVLRYFLELKGSCNLDEDVSSQI 752
            |.:                |::::::..| |..|.:.:..::.:...::|::......:| ::..
  Rat   555 DMK----------------LMRRYIAMCR-ERQPTVPDSLADYITAAYVEMRREARASKD-ATYT 601

  Fly   753 GAGQLLAIIHLSQARARLDLSHVVSPQHVRDVIALLTESITQTSLKEGSSRQGTRGGGGAGGGAG 817
            .|..||||:.||.|.|||.:..:|..:.|.:.|.|:  .:::.||.            |..|...
  Rat   602 SARTLLAILRLSTALARLRMVDIVEKEDVNEAIRLM--EMSKDSLL------------GEKGQTA 652

  Fly   818 KSAQLRNFLELTKRRSAALGRRIFEFDELKEIGTRAGILTGFSQLVEMANLGGYLLMKGANMYEV 882
            ::.:..:.:..|.|...:.||.: .|.|.::    ..|..||:.....|.|..|   :..|:::|
  Rat   653 RTQRPADVIFATVRELVSGGRSV-RFSEAEQ----RCISRGFTPAQFQAALDEY---EELNVWQV 709

Fly 883 882
Rat 710 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rec	NP_001262615.1	RNR_PFL	<117..200	CDD:299130
		MCM	243..792	CDD:214631	139/575 (24%)
		P-loop_NTPase	468..606	CDD:304359	43/143 (30%)
Mcm7	NP_001004203.3	MCM_N	12..165	CDD:291233	14/66 (21%)
		MCM	145..641	CDD:214631	140/579 (24%)
		P-loop_NTPase	376..515	CDD:304359	43/143 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820