DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rec and mcm5

DIOPT Version :9

Sequence 1:	NP_001262615.1	Gene:	rec / 49241	FlyBaseID:	FBgn0003227	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_848523.2	Gene:	mcm5 / 286747	ZFINID:	ZDB-GENE-021209-1	Length:	736	Species:	Danio rerio

Alignment Length:	743	Identity:	170/743 - (22%)
Similarity:	290/743 - (39%)	Gaps:	163/743 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 IKSDAQLKEVW--------PSLSEDIRE----HPLRTLGTLSLAMHTVVVNHQLDCNDSTTAMVS 218
            :|....|.|.|        .|..||:.:    .|...|..|..|...|.        |..|....
Zfish    60 LKRHYTLGEYWIEVEMEDLASFDEDLSDCLYKLPSENLPLLEEAAQEVA--------DEVTRPRP 116

  Fly   219 TPEQYVLPTPRVRKIYARPDDFVPVESIEGISHSRVDTLFSIRGFVSNVGEPSYSLTWQAFRCSR 283
            ..|:.|.....:.|..|.|      .||..:...:|..|..|.|.:.:........|....:|..
Zfish   117 VGEETVQDIQVMLKSDAHP------ASIRSLKSEQVSRLVKIPGIIISSTAVRAKATRVCLQCRG 175

  Fly   284 CQMEIA-----MRQRGTFQPR---PYQCKRSECVARDEFVPLRSSPYTRLSIR------QIIRVE 334
            |:..|:     ...:|...||   ..|..|.:|       |:  .||..:..|      |..|::
Zfish   176 CRAVISNIPLPPGLQGYALPRKCNTEQAGRVKC-------PV--DPYFIIPDRCVCVDFQTQRLQ 231

  Fly   335 ESSLNLVHDFETSMPAEMDVELRHDLVDAVRVGQEVVVTGILKLQEL------GDDTTTGDTSNQ 393
            |:...:.|.   .||..|.:.....|.|.|..|..|.|.||..::::      |.|..||  ...
Zfish   232 EAPDAVPHG---EMPRHMQLYCDRYLCDRVVPGNRVTVMGIYSIKKVAQTKAKGRDKGTG--VGI 291

  Fly   394 MQPYLKAVSI--------RDASSIKREFSERDLEAIVMINAEPNSFKLLVQSIAPEVYG-HELPK 449
            ...||:.|.|        |.|:.......|.:|.::.   |.|:.:..|.:|:||.:|| .:|.|
Zfish   292 RSAYLRVVGIDVDTEGAGRGATGSVSPQEEEELRSLA---ASPSVYDSLARSLAPSIYGSDDLKK 353

  Fly   450 A-ACLLSLLGGK------GAETEA-INVLLVGDPGIGKTKILQSCAQIAERGAHVSGKRGAQSAQ 506
            | |||  |.||.      |..... ||:|::||||..|:::|:...:.:..|.:.||| |:.:|.
Zfish   354 AIACL--LFGGSRKRLPDGLTRRGDINLLMLGDPGTAKSQLLKFVERCSPIGVYTSGK-GSSAAG 415

  Fly   507 QLGVTFAGRNKR--VLQAGSLMMASGGGHCTLDDVDKLASKQAVLL-QCLQSEEVNLPLAGAFAS 568
            ...........|  |::.|::::|.||..| :|:.||:.....|.: :.::.:.:::..||...:
Zfish   416 LTASVLRDPTTRGFVMEGGAMVLADGGVVC-IDEFDKMREDDRVAIHEAMEQQTISIAKAGITTT 479

  Fly   569 FPAQPSVIACANPQRGQYDE--GRYLLQNINISPSLLREFHLVYILLD-KPSERDMSLTAHVRAL 630
            ..::.||:|.||...|::|:  |.   .||:..|::|..|.:::|:.| ...:|||:|..||..:
Zfish   480 LNSRCSVLAAANSVFGRWDDTKGE---DNIDFMPTILSRFDMIFIIKDHHDQQRDMTLARHVMNV 541

  Fly   631 HAGARKRARIAARYALKPKMSDSMCEVSLNVPAAGKDDDTIKTEDDNDSIMQQDYDLDKRLEVLP 695
            |..|:.:.
Zfish   542 HLSAQTQT--------------------------------------------------------- 549

  Fly   696 EEGDLDLLPPILIKKFLSYARQELNPVLNEDASNAVL-RYFLELKGS----CNLDEDVSSQIGAG 755
             ||....:|...:||:::|:|.:..|.|:..|:..:. ||.|...|:    ...|..||..|...
Zfish   550 -EGVEGEIPLATLKKYIAYSRVKCGPRLSAAAAEKLKNRYVLMRSGAKEHERETDRRVSIPITVR 613

  Fly   756 QLLAIIHLSQARARLDLSHVVSPQHVRDVIALLTESITQTSLKEGSSRQGTRGGGGAGGGAGKSA 820
            ||.|::.::::.|::.|..:...:.|.:.:.|...|....:|....|       |..|....:..
Zfish   614 QLEAVVRIAESLAKMKLQPIAGEEEVDEALRLFQVSTLDAALSGSLS-------GVEGFTTQEDQ 671

  Fly   821 QLRNFLELTKRRSAALGRRIFEFDELKE 848
            ::.:.:|...:|..|:|.::.|...:::
Zfish   672 EMISRIEKQLKRRFAIGSQVSEHSIIQD 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rec	NP_001262615.1	RNR_PFL	<117..200	CDD:299130	11/45 (24%)
		MCM	243..792	CDD:214631	141/596 (24%)
		P-loop_NTPase	468..606	CDD:304359	39/142 (27%)
mcm5	NP_848523.2	MCM_N	35..154	CDD:291233	24/107 (22%)
		MCM	134..651	CDD:214631	143/604 (24%)
		AAA	378..522	CDD:99707	40/148 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820