DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rec and mcm2

DIOPT Version :9

Sequence 1:	NP_001262615.1	Gene:	rec / 49241	FlyBaseID:	FBgn0003227	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_775364.2	Gene:	mcm2 / 192338	ZFINID:	ZDB-GENE-020419-24	Length:	889	Species:	Danio rerio

Alignment Length:	740	Identity:	158/740 - (21%)
Similarity:	293/740 - (39%)	Gaps:	181/740 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 RDRGFFPLCAAGIKSDAQLKEVWPSLS--EDIREHPLRTLGTLSLAMHTVVVNHQLD-------- 208
            |.|......|.|...:.:.:|:..|:.  ||::.|.:|.  .:|:|...:.:.|:..
Zfish   134 RQRVLAERAAEGGAMEGEDEEMIESIENLEDMKGHTVRE--WVSMAAPRLEIYHRFKNFLRTHVD 196

  Fly   209 --------------CNDSTTAMVSTPEQ---------YVLPT---------------------PR 229
                          |.::..:::...|:         |.||.                     |:
Zfish   197 EHGHNVFKERISDMCKENKESLLVNYEELASREHVLAYFLPEAPAEMLKIFDEAAKEVVLAMYPK 261

  Fly   230 ----VRKIYARPDDFVPVESIEGISHSRVDTLFSIRGFVSNVGEPSYSLTWQAFRCSRCQMEIAM 290
                ..:|:.|..:...||.:..:....::.|....|.|::.......|....:.|::|...:
Zfish   262 YDRIAHEIHVRIGNLPLVEELRSLRQLHLNQLIRTSGVVTSCTGVLPQLGMVKYNCNKCNFIL-- 324

  Fly   291 RQRGTF------QPRPYQCKRSECVARDEF-VPLRSSPYTRLSIRQIIRVEESSLNLVHDFETSM 348
               |.|      :.:|..|  .||.:...| :.:..:.|...   |.|.::||...:.   ...:
Zfish   325 ---GPFFQSQNQEVKPGSC--PECQSLGPFEINMEQTVYQNY---QRITIQESPGKVA---AGRL 378

  Fly   349 PAEMDVELRHDLVDAVRVGQEVVVTGILKLQELGDDTTTGDTSNQMQ---PYLKAVSI------R 404
            |...|..|..||||..:.|.|:.:|||..        ...|.|..|.   |....|.:      :
Zfish   379 PRSKDAILLADLVDMCKPGDEIELTGIYH--------NNYDGSLNMANGFPVFATVILANHIARK 435

  Fly   405 DASSIKREFSERDLEAIVMINAEPNSFKLLVQSIAPEVYGHELPKAACLLSLLGGK----GAETE 465
            |......|.::.|::|||.::.:....:.:..||.|.:|.||..|....|:|.||:    |.:.:
Zfish   436 DEGVAVAELTDEDVKAIVALSKDERIGERIFASIGPSIYAHEDIKRGLALALFGGEAKNPGGKHK 500

  Fly   466 A---INVLLVGDPGIGKTKILQSCAQIAERGAHVSGKRGAQSAQQLGVT-FAGRN----KRVLQA 522
            .   |||||.||||..|::.|:...::|.|....:|    |.|..:|:| :..|:    :..|:|
Zfish   501 VRGDINVLLCGDPGTAKSQFLKYVEKVASRAVFTTG----QGASAVGLTAYVQRHPVSREWTLEA 561

  Fly   523 GSLMMASGGGHCTLDDVDKLASKQAVLL-QCLQSEEVNLPLAGAFASFPAQPSVIACANPQRGQY 586
            |:|::|. .|.|.:|:.||:..:....: :.::.:.:::..||...|..|:.:|||.|||..|:|
Zfish   562 GALVLAD-RGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRY 625

  Fly   587 DEGRYLLQNINISPSLLREFHLVYILLD--KPSERDM----SLTAHVRALHAGARKRARIAARYA 645
            |......:|::::..::..|.::.::.|  .|.:.:|    .:.:|::  |..:.|...:|.
Zfish   626 DPSLTFSENVDLTEPIISRFDVLCVVRDTVDPVQDEMLARFVVGSHIK--HHPSNKEGGVAG--- 685

  Fly   646 LKPKMSDSMCEVSLNVPAAGKDDDTIKTEDDNDSIMQQDYDLDKRLE--VLPEEGDLDLLPPILI 708
                                                         ||  |||...|:..:|..|:
Zfish   686 ---------------------------------------------LEEVVLPNTFDVPPIPQELL 705

  Fly   709 KKFLSYARQELNPVLNEDASNAVLRYFLELKGSCNLDEDV---SSQIGAGQLLAIIHLSQARARL 770
            :|::.||::.:.|.||:...:.|.|.:.:|:     .|.:   |..|....:.::|.:::|.||:
Zfish   706 RKYIIYAKERVRPKLNQMDQDKVARIYSDLR-----KESMATGSIPITVRHIESMIRMAEAHARM 765

  Fly   771 DLSHVVSPQHVRDVIALLTESITQT 795
            .|...|....|...|.::.||...|
Zfish   766 HLRDYVLEDDVNMAIRVMLESFIDT 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rec	NP_001262615.1	RNR_PFL	<117..200	CDD:299130	12/47 (26%)
		MCM	243..792	CDD:214631	135/588 (23%)
		P-loop_NTPase	468..606	CDD:304359	42/143 (29%)
mcm2	NP_775364.2	MCM2_N	57..170	CDD:289392	9/35 (26%)
		MCM_N	186..298	CDD:291233	11/111 (10%)
		MCM	279..788	CDD:214631	136/589 (23%)
		P-loop_NTPase	506..645	CDD:304359	42/143 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920