DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rec and mcm3

DIOPT Version :9

Sequence 1:	NP_001262615.1	Gene:	rec / 49241	FlyBaseID:	FBgn0003227	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_997732.2	Gene:	mcm3 / 192323	ZFINID:	ZDB-GENE-020419-4	Length:	807	Species:	Danio rerio

Alignment Length:	516	Identity:	139/516 - (26%)
Similarity:	237/516 - (45%)	Gaps:	75/516 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   335 ESSLNLVHDFET-------------SMPAEMDVELRHDLVDAVRVGQEVVVTGILKLQELGDDTT 386
            |..|::..|.:|             .:|..:|:.|.:||||||:.|....|.|..:..   ....
Zfish   186 EFGLSVYKDHQTITIQEMPEKAPAGQLPRSVDIILDNDLVDAVKPGDRTQVIGTYRCL---PGKK 247

  Fly   387 TGDTSNQMQPYLKAVSIRDAS-SIKREFSERDLEAIVMI--NAEPNSFKLLVQSIAPEVYGHELP 448
            .|.||...:..:.|..::..| .|...||..|:..|...  :...|.|..|.:|:||.::|||..
Zfish   248 GGFTSGTFRTIMIACHVKQMSKEISHYFSADDVAKIKSFCRSRSKNVFDQLARSLAPSIHGHEYI 312

  Fly   449 KAACLLSLLGG------KGAETEA-INVLLVGDPGIGKTKILQSCAQIAERGAHVSGKRGAQSAQ 506
            |.|.|..||||      .|:.... |||||:|||.:.|:::|:.....|.|....:| ||:..
Zfish   313 KKAILCMLLGGVEKVLENGSRIRGDINVLLIGDPSVAKSQLLRYVLHTAPRAIPTTG-RGSSG-- 374

  Fly   507 QLGVTFA-----GRNKRVLQAGSLMMASGGGHCTLDDVDKLAS-KQAVLLQCLQSEEVNLPLAGA 565
             :|:|.|     ...:|.|:||::::...|..| :|:.||::. .:..:.:.::...|.:..||.
Zfish   375 -VGLTAAVTTDQETGERRLEAGAMVLGDRGVVC-IDEFDKMSDMDRTAIHEVMEQGRVTIAKAGI 437

  Fly   566 FASFPAQPSVIACANPQRGQYDEGRYLLQNINISPSLLREFHLVYILLDK-PSERDMSLTAHVRA 629
            .|...|:.||:|.|||..|:||:.:..::||.:..|||..|.|::|:||: ..|:|..::.||..
Zfish   438 HARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLR 502

  Fly   630 LHAGARKRARIAARYALKPKMSDSMCEVSLNVPAAGKDDDTIKTEDDNDSIMQQDYDLDKRLEVL 694
            :|           ||. .|...|.      ...|.|...|.:.|||. |:..::    ::.|:|.
Zfish   503 MH-----------RYR-DPHEQDG------TALALGGTIDALATEDP-DATQEE----EEELQVY 544

  Fly   695 PEEGDL---------DLLPPILIKKFLSYARQELNPVLNEDASNAVLRYFLELKGSCNLDEDV-- 748
            .:...|         .::....::|::..|: .::|||.:||:|.:...:..|:....|..|:
Zfish   545 EKHNPLLHGSKKNKDRVVSKAFMRKYIHVAK-AISPVLTQDAANHIAEEYSRLRNQEQLGSDIAR 608

  Fly   749 SSQIGAGQLLAIIHLSQARARLDLSHVVSPQHVRDVIALLTESITQTSLKEGSSRQGTRGG 809
            :|.:.|..|..:|.||.|.|:..:|..|........:.|:..:..:..|::  .|:.:|.|
Zfish   609 TSPVTARTLETLIRLSTAHAKARMSKAVELVDTEVAVELVQFAYFKKVLEK--ERKRSRNG 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rec	NP_001262615.1	RNR_PFL	<117..200	CDD:299130
		MCM	243..792	CDD:214631	135/497 (27%)
		P-loop_NTPase	468..606	CDD:304359	45/143 (31%)
mcm3	NP_997732.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820