DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rec and mcm-7

DIOPT Version :9

Sequence 1:	NP_001262615.1	Gene:	rec / 49241	FlyBaseID:	FBgn0003227	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_504199.1	Gene:	mcm-7 / 178831	WormBaseID:	WBGene00003159	Length:	730	Species:	Caenorhabditis elegans

Alignment Length:	721	Identity:	154/721 - (21%)
Similarity:	289/721 - (40%)	Gaps:	169/721 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 DGLQVQSIAVDNPRAYSGWRLYFLREKYEE--GNELATRIMAVEAYYQRNPHTFDFVMIRDRGFF 159
            |.|::......|.:.|.......:.:..::  |::.|..|.|::||..:..|     |.|:.|
Worm    67 DALELSEAITSNTKRYEVLFKDTISDMIQDYLGDKQAPVIDALDAYMFQRLH-----MDRNEG-- 124

  Fly   160 PLCAAGIKSDAQLKEVWPSLSEDIREHPLRTLGTLSLAMHTVVVNHQLDCNDSTTAMVSTPEQYV 224
                      |..:||  ||.:..:::|.:.|...
Worm   125 ----------AANEEV--SLQDKRKKYPPQLLQRF------------------------------ 147

  Fly   225 LPTPRVRKIYARPDDFVPVESIEGISHSRVDTLFSIRGFVSNVGEPSYSLTWQAFRCSRCQMEIA 289
                   ::|...||......:..|..:.:..|.|::|.|....|....:....:.|..|..|:.
Worm   148 -------EVYFTTDDAAHETCVRNIKATEIGHLVSMKGVVIRATEVKPCVEVMTYTCDTCAAEVY 205

  Fly   290 MRQRG-TFQPRPYQCKRSECVARDE----FVPLRSSPYTRLSIRQIIRVEESSLNLVHDFETSMP 349
            ...:| .|.| |..|...|||....    .:.||.|.:.:.   |.::::|.|..:.   ..|:|
Worm   206 QPVKGMQFTP-PVNCPNKECVEAKANGRLHMQLRGSKFVKF---QELKIQELSEQVP---VGSIP 263

  Fly   350 AEMDVELRHDLVDAVRVGQEVVVTGI-LKLQELGDDTTTG---DTSNQMQPYLKA--VSIRDASS 408
            ..|.|.:..::......|..|.|:|: |.:.:.|...|.|   ||      ||:|  ::..|.:.
Worm   264 RTMTVHVYGEMTRKCNTGNVVHVSGVFLPIMQSGFRPTGGLVADT------YLEAHYINNLDDNP 322

  Fly   409 IKREFSERDLEAIVMINAEPNSFKLLVQSIAPEVYGHELPKAACLLSLLGGKGAETE------AI 467
            ........:||   ::..:.::::.|..|||||::||...|...|::|:||....:.      .|
Worm   323 TFNGVQSAELE---VLRRKGDNYETLAASIAPEIFGHVDVKKCLLMALVGGNDNSSNGMKIRGCI 384

  Fly   468 NVLLVGDPGIGKTKILQSCAQIAERGAHVSGKRGAQSAQQLGVTFAGRNKRV-----LQAGSLMM 527
            |||::||||:.|:::|....::|.|..:.:| ||:..   :|:|.|.....|     |:.|:|::
Worm   385 NVLMMGDPGVAKSQLLGYVNRLAPRSQYTTG-RGSSG---VGLTAAVMKDPVTGEMSLEGGALVL 445

  Fly   528 ASGGGHCTLDDVDKLAS-KQAVLLQCLQSEEVNLPLAGAFASFPAQPSVIACANPQRGQYDEGRY 591
            |. ||.|.:|:.||:.. .:..:.:.::.:.:::..||...:..|:.::||.|||..|:|:..|.
Worm   446 AD-GGICCIDEFDKMMDHDRTAIHEVMEQQTISIAKAGIMTTLNARTAIIAAANPAYGRYNPNRS 509

  Fly   592 LLQNINISPSLLREFHLVYILLDKPS-ERDMSLTAHVRALHAGARKRARIAARYALKPKMSDSMC 655
            :.||:::..:||..|.|:.::.||.. |.|..|..|:..:|...                    |
Worm   510 IEQNVDLPAALLSRFDLILLMQDKADRENDKILAEHITYVHQHG--------------------C 554

  Fly   656 EVSLNVPAAGKDDDTIKTEDDNDSIMQQDYDLDKRLEVLPEEGDLDLLPPILIKKFLSYAR---Q 717
            .                                      |.....||:....:::::|..:   .
Worm   555 H--------------------------------------PNREKKDLISLETLREYISLCKTYTP 581

  Fly   718 ELNPVLNEDASNAVLRYFLELKGSCNLDEDVSSQIGAGQLLAIIHLSQARARLDLSHVVSPQHVR 782
            .::|.|.|    .::..::|::.......| .:.:....:|.|:.::.|||:|.||.:|....|.
Worm   582 TVDPALRE----RIVEAYVEMRRDARYSSD-PTFVSPRMILGIVRMATARAKLRLSTIVDESDVE 641

  Fly   783 DVIALL 788
            :.:.|:
Worm   642 EALRLM 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rec	NP_001262615.1	RNR_PFL	<117..200	CDD:299130	17/84 (20%)
		MCM	243..792	CDD:214631	130/573 (23%)
		P-loop_NTPase	468..606	CDD:304359	43/143 (30%)
mcm-7	NP_504199.1	MCM_N	16..178	CDD:291233	27/166 (16%)
		MCM	162..651	CDD:214631	130/570 (23%)
		P-loop_NTPase	385..524	CDD:304359	43/143 (30%)
		CarD_CdnL_TRCF	<619..715	CDD:294393	10/29 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820