DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rec and mcm-2

DIOPT Version :9

Sequence 1:	NP_001262615.1	Gene:	rec / 49241	FlyBaseID:	FBgn0003227	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_001022416.1	Gene:	mcm-2 / 174841	WormBaseID:	WBGene00003154	Length:	881	Species:	Caenorhabditis elegans

Alignment Length:	840	Identity:	188/840 - (22%)
Similarity:	326/840 - (38%)	Gaps:	205/840 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 DAPSVPPATRQPRGWSRTAGKRGRNAHLDCSFLRPENYAAPEDGLQ------------VQSIAVD 107
            |..|....||:     |..|:|||....|...:..|....|.|.|:            .:::|.:
Worm   108 DGDSEEVDTRR-----RGRGRRGRGDAADDDSVPMEEEDIPVDILENIRGRTIRDHVSDEAVAKE 167

  Fly   108 NPRAYSGWRLYFLREKYEEGNELATRIMAVEAYYQRNPHTFDFVMIRDRGFFPLCAAGIKSDAQL 172
            ..|.:..    |||..:|.||:....|..:::....|..:                        |
Worm   168 IERRFKN----FLRSFHEPGNKQTKYIQMIKSMAADNRES------------------------L 204

  Fly   173 KEVWPSLSED---------IREHPLRTLGTLSLAMHTVVVN----HQLDCNDSTTAMVSTPEQYV 224
            :..:..||:|         :.|.|...|..:..|...||:|    :...||:....:...|.:
Worm   205 EVSFTDLSDDNGEQNISYFLPEAPNEMLAIMDRAATEVVMNMYPFYSRVCNEIKVRISQLPVE-- 267

  Fly   225 LPTPRVRKIYARPDDFVPVESIEGISHSRVDTLFSIRGFVSNVGEPSYSLTWQAFRCSRCQMEIA 289
                               |.|..:....::.|....|.|:........|....:.|..|...:.
Worm   268 -------------------EDIRMLRQVHLNMLIRTAGVVTIASGILPQLAVVKYDCVACGYLLG 313

  Fly   290 -MRQRGTFQPRPYQCKRSECVARDEF-VPLRSSPYTRLSIRQIIRVEESSLNLVHDFETSMPAEM 352
             ..|:...:.||..|  ..|..:..| :.:.::.|...   |.|.::||...:.   ...:|...
Worm   314 PFVQQNDEEVRPTIC--PSCQGKGPFELNVENTVYHNY---QRITMQESPNKVA---AGRLPRSK 370

  Fly   353 DVELRHDLVDAVRVGQEVVVTGILKLQELGDDTTTGDTS-NQMQPYLKAVSIRDASSIKR----- 411
            ||.|..||.|:.:.|.|:.|||:.        |...|.| |..|.:....::..|:.|..
Worm   371 DVILLGDLCDSCKPGDEIEVTGVY--------TNNFDGSLNYKQGFPVFNTLIHANHITNKDKMA 427

  Fly   412 --EFSERDLEAIVMINAEPNSFKLLVQSIAPEVYGHELPKAACLLSLLGGKGAETEA-------I 467
              :.::.|::||..::.:||..:.:..||||.:|||:..|.|..|:|..|:.....|       |
Worm   428 SDQLTDEDIKAIRELSQDPNISQRVFSSIAPSIYGHDDVKRAIALALFRGEAKNPGAKHRLRGDI 492

  Fly   468 NVLLVGDPGIGKTKILQSCAQIAERGAHVSGKRGAQSAQQLGVT-FAGRN----KRVLQAGSLMM 527
            ||||.||||..|::.|:..|.||.|....:|    |.|..:|:| :..|:    :..|:||::::
Worm   493 NVLLCGDPGTAKSQFLRYAAHIAPRSVLTTG----QGASAVGLTAYVQRHPVTREWTLEAGAMVL 553

  Fly   528 ASGGGHCTLDDVDKLASKQAVLL-QCLQSEEVNLPLAGAFASFPAQPSVIACANPQRGQYDEGRY 591
            |. .|.|.:|:.||::.:....: :.::.:.:::..||...|..|:.:|||.:||..|:|:..|.
Worm   554 AD-KGVCLIDEFDKMSDQDRTSIHEAMEQQSISISKAGIVTSLHARCTVIAASNPIGGRYNPTRT 617

  Fly   592 LLQNINISPSLLREFHLVYILLDK-PSERDMSLTAHV----RALHAGARKRARIAARYALKPKMS 651
            ..:|::::..:|..|.::.::.|. .|..|..|...|    |..|..|:|
Worm   618 FAENVDLTEPILSRFDVLCVIRDSVDSVEDERLAKFVVGNHRTHHPDAKK--------------- 667

  Fly   652 DSMCEVSLNVPAAGKDDDTIKTEDDNDSIMQQDYDLDKRLEVLPEEGDLDLLPPILIKKFLSYAR 716
                              .:|..|:    :::| .:|:|..|       .|:|..|::|::.|||
Worm   668 ------------------IVKEGDE----LEED-QMDERTGV-------RLIPQDLLRKYIIYAR 702

  Fly   717 QELNPVLNEDASNAVLRYFLELKGSCNLDEDVSSQIGAGQLLAIIHLSQARARLDLSHVVSPQHV 781
            ::.:|.|.|..|......|.:::........|:  |....:.::|.||:|.|:|.|...|:.:..
Worm   703 EKCHPTLPEQHSEKFSNIFAQMRKESMATGSVA--ITVRHVESMIRLSEAHAKLHLRSYVNDEDC 765

  Fly   782 RDVIALLTESITQTS-------LKEGSSRQGTRGGGGAGGGAGKSAQLRNFLELTKRRSA 834
            ...|.::.||...|.       :|:..||                       .||:.|||
Worm   766 AAAIRVMLESFVNTQKASIMRMMKKTFSR-----------------------HLTENRSA 802

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rec	NP_001262615.1	RNR_PFL	<117..200	CDD:299130	16/91 (18%)
		MCM	243..792	CDD:214631	140/576 (24%)
		P-loop_NTPase	468..606	CDD:304359	43/143 (30%)
mcm-2	NP_001022416.1	MCM2_N	48..>103	CDD:289392
		MCM_N	171..286	CDD:291233	25/163 (15%)
		MCM	270..777	CDD:214631	140/574 (24%)
		AAA	461..639	CDD:99707	54/182 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2613
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.870