DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rec and Mcm5

DIOPT Version :9

Sequence 1:	NP_001262615.1	Gene:	rec / 49241	FlyBaseID:	FBgn0003227	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_001289469.1	Gene:	Mcm5 / 17218	MGIID:	103197	Length:	734	Species:	Mus musculus

Alignment Length:	786	Identity:	182/786 - (23%)
Similarity:	310/786 - (39%)	Gaps:	194/786 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 FLREKYEEGNELATRIMAVEAYYQRNPHTFDFVMIRDRGFFPLCAAGIKSDAQLKEVW------- 176
            |||: |..|.:             |...||.:   ||.         :|....|.|.|
Mouse    38 FLRQ-YRVGTD-------------RTGFTFKY---RDE---------LKRHYNLGEYWIEVEMED 76

  Fly   177 -PSLSEDIREH----PLRTLGTLSLAMHTVVVNHQLDCNDSTTAMVSTPEQYVLPTPRVRKIYAR 236
             .|..|::.:|    |...|..|..|...|.        |..|......::.:.....:.|..|.
Mouse    77 LASFDEELADHLHKQPAEHLQLLEEAAKEVA--------DEVTRPRPAGDELLQDIQVMLKSDAS 133

  Fly   237 PDDFVPVESIEGISHSRVDTLFSIRGFVSNVGEPSYSLTWQAFRCSRCQ---MEIAMRQ--RGTF 296
            |      .||..:....:..|..|.|.:.:........|..:.:|..|.   ..||||.  .|..
Mouse   134 P------SSIRILKSDMMSHLVKIPGIIISASAVRAKATRISIQCRSCHNTLTNIAMRPGLEGYA 192

  Fly   297 QPRPY---QCKRSECVARDEFVPLRSSPYTRLSIR------QIIRVEESSLNLVHDFETSMPAEM 352
            .||..   |..|.:|       ||  .||..:..:      |.::::|....:.|.   .||..|
Mouse   193 LPRKCNMDQAGRPKC-------PL--DPYFIMPDKCKCVDFQTLKLQELPDAVPHG---EMPRHM 245

  Fly   353 DVELRHDLVDAVRVGQEVVVTGILKLQELG-------DDTTTGDTSNQMQPYLKAVSIR-DASSI 409
            .:.....|.|.|..|..|.:.||..:::.|       |....|..|:    |::.:.|: |....
Mouse   246 QLYCDRYLCDKVVPGNRVTIMGIYSIKKFGLNPSKGRDRVGVGIRSS----YIRVLGIQVDTDGS 306

  Fly   410 KREF----SERDLEAIVMINAEPNSFKLLVQSIAPEVY-GHELPKA-ACLLSLLGGK------GA 462
            .|.|    |.::.|....:.|.||.::|:.:||:|.:: |.::.|| |||  |.||.      |.
Mouse   307 GRSFAGSVSPQEEEEFRRLAALPNIYELISKSISPSIFGGMDMKKAIACL--LFGGSRKRLPDGL 369

  Fly   463 ETEA-INVLLVGDPGIGKTKILQSCAQIAERGAHVSGKRGAQSAQQLGVTF------AGRNKRVL 520
            .... ||:|::||||..|:::|:...:.:..|.:.||| |:.:|   |:|.      :.|| .::
Mouse   370 TRRGDINLLMLGDPGTAKSQLLKFVEKCSPIGVYTSGK-GSSAA---GLTASVIRDPSSRN-FIM 429

  Fly   521 QAGSLMMASGGGHCTLDDVDKLASKQAVLL-QCLQSEEVNLPLAGAFASFPAQPSVIACANPQRG 584
            :.|::::|.||..| :|:.||:.....|.: :.::.:.:::..||...:..::.||:|.||...|
Mouse   430 EGGAMVLADGGVVC-IDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVFG 493

  Fly   585 QYDE--GRYLLQNINISPSLLREFHLVYILLDKPS-ERDMSLTAHVRALHAGARKRARIAARYAL 646
            ::||  |.   .||:..|::|..|.:::|:.|:.: ||||.|..||..||..|..:.:..
Mouse   494 RWDETKGE---DNIDFMPTILSRFDMIFIVKDEHNEERDMMLAKHVMTLHVSALTQTQAV----- 550

  Fly   647 KPKMSDSMCEVSLNVPAAGKDDDTIKTEDDNDSIMQQDYDLDKRLEVLPEEGDLDLLPPILIKKF 711
                                                              ||::||..   :|||
Mouse   551 --------------------------------------------------EGEIDLAK---MKKF 562

  Fly   712 LSYARQELNPVLNEDASNAVL-RYFLELKGSCNLDED----VSSQIGAGQLLAIIHLSQARARLD 771
            ::|.|....|.|:.:|:..:. ||.:...|:...:.|    .|..|...||.||:.:::|.:::.
Mouse   563 IAYCRARCGPRLSAEAAEKLKNRYIIMRSGARQHERDSDRRSSIPITVRQLEAIVRIAEALSKMK 627

  Fly   772 LSHVVSPQHVRDVIALLTESITQTSLKEGSSRQGTRGGGGAGGGAGKSAQLRNFLELTKRRSAAL 836
            |....:...|.:.:.|...|....:|....|       |..|....:..::.:.:|...:|..|:
Mouse   628 LQPFATEADVEEALRLFQVSTLDAALSGNLS-------GVEGFTTQEDQEMLSRIEKQLKRRFAI 685

  Fly   837 GRRIFE 842
            |.::.|
Mouse   686 GSQVSE 691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rec	NP_001262615.1	RNR_PFL	<117..200	CDD:299130	21/92 (23%)
		MCM	243..792	CDD:214631	145/598 (24%)
		P-loop_NTPase	468..606	CDD:304359	42/146 (29%)
Mcm5	NP_001289469.1	MCM_N	35..130	CDD:379644	24/125 (19%)
		MCM	133..649	CDD:214631	147/606 (24%)
		Arginine finger	512..515		0/2 (0%)
		BREX_BrxC	<618..>730	CDD:380283	14/81 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820