DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rec and Mcm4

DIOPT Version :9

Sequence 1:	NP_001262615.1	Gene:	rec / 49241	FlyBaseID:	FBgn0003227	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_032591.3	Gene:	Mcm4 / 17217	MGIID:	103199	Length:	862	Species:	Mus musculus

Alignment Length:	886	Identity:	188/886 - (21%)
Similarity:	338/886 - (38%)	Gaps:	249/886 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 RNGRVIPAGGNR------QPN---QGEPGA-------PDAPSV----PPATRQPRGWSRTAGKRG 77
            |.|||.|....|      .||   :||..:       |.:|..    |||  |...:|.......
Mouse    14 RRGRVTPTQSLRSEESRSSPNRRRRGEDSSTGELLPMPTSPGADLQSPPA--QNALFSSPPQMHS 76

  Fly    78 RNAHLDCSFLRPENYAAPED--------------------------GLQV----QSIAVDN--PR 110
            ....||.....|..|..|..                          ||||    ...|.::  |.
Mouse    77 LAIPLDFDVSSPLTYGTPSSRVEGTPRSGVRGTPVRQRPDLGSARKGLQVDLQSDGAAAEDIVPS 141

  Fly   111 AYS-GWRLYF---------LREKYEEGNELATRIMAVE-----------AYYQRNPHTFDFVMIR 154
            ..| |.:|..         .:|.::...:..|..:|.|           .|.|:    ...:.|.
Mouse   142 EQSLGQKLVIWGTDVNVATCKENFQRFLQCFTDPLAKEEENVGIDITQPLYMQQ----LGEINIT 202

  Fly   155 DRGFFPLCAAGIKSDAQLKEVWPSLSEDIREHPLRTLGTLSLAMHTV--------VVNHQLDCND 211
            ...|..:....|||.::      :|...:..:|...:.|..:|::.:        ::.||
Mouse   203 GEPFLNVNCEHIKSFSK------NLYRQLISYPQEVIPTFDMAVNEIFFDRYPDSILEHQ----- 256

  Fly   212 STTAMVSTPEQYVLPTPRVRKIYARPDDFVPVESIEGISHSRVDTLFSIRGFVSNVGEPSYSLTW 276
                                 |..||.:.:..:|:..::...:|.|.:|.|.|....:....:..
Mouse   257 ---------------------IQVRPFNALKTKSMRNLNPEDIDQLITISGMVIRTSQLIPEMQE 300

  Fly   277 QAFRCSRC----QMEIAMRQRGTF-QPRPYQCKRSECVARDEFVPLRSSPYTRLSIRQIIRVEES 336
            ..|:|..|    ::||   .||.. :|    |....|........:.:..:  .|.:|:|:::||
Mouse   301 AFFQCQVCAHTTRVEI---DRGRIAEP----CSCVHCHTTHSMALIHNRSF--FSDKQMIKLQES 356

  Fly   337 SLNLVHDFETSMPAEMDVELRH-DLVDAVRVGQEVVVTGILKLQELGDDTTTGDTSNQMQPYLKA 400
            .    .|..........|...| ||||.|:.|..|.||||.:...:..:....:..:..:.::..
Mouse   357 P----EDMPAGQTPHTIVLFAHNDLVDKVQPGDRVNVTGIYRAVPIRVNPRVSNVKSVYKTHIDV 417

  Fly   401 VSIR----------DASSIKREFSERDLEAIVMINAEPNSFKLLVQSIAPEVYGHELPKAACLLS 455
            :..|          |..:.::.|||:.::.:..::.:|:.::.|..::||.:|.||..|...||.
Mouse   418 IHYRKTDAKRLHGLDEEAEQKLFSEKRVKLLKELSRKPDIYERLASALAPSIYEHEDIKKGILLQ 482

  Fly   456 LLG---------GKGAETEAINVLLVGDPGIGKTKILQSCAQIAERGAHVSGKRGAQSAQQLGVT 511
            |.|         |:|.....||:||.||||..|:::||....:..||.:.|||    .:..:|:|
Mouse   483 LFGGTRKDFSHTGRGKFRAEINILLCGDPGTSKSQLLQYVYNLVPRGQYTSGK----GSSAVGLT 543

  Fly   512 F-----AGRNKRVLQAGSLMMASGGGHCTLDDVDKL-ASKQAVLLQCLQSEEVNLPLAGAFASFP 570
            .     ....:.|||.|:|:: |..|.|.:|:.||: .|.::||.:.::.:.:::..||......
Mouse   544 AYVMKDPETRQLVLQTGALVL-SDNGICCIDEFDKMNESTRSVLHEVMEQQTLSIAKAGIICQLN 607

  Fly   571 AQPSVIACANPQRGQYDEGRYLLQNINISPSLLREFHLVYILLDKPSER-DMSLTAHVRALHAGA 634
            |:.||:|.|||...|::..:..::||.:..:||..|.|::::||...|. |..|..|:.:|:
Mouse   608 ARTSVLAAANPIESQWNPKKTTIENIQLPHTLLSRFDLIFLMLDPQDEAYDRRLAHHLVSLY--- 669

  Fly   635 RKRARIAARYALKPKMSDSMCEVSLNVPAAGKDDDTIKTEDDNDSIMQQDYDLDKRLEVLPEEGD 699
                                                              |..::::    ||..
Mouse   670 --------------------------------------------------YQSEEQV----EEEF 680

  Fly   700 LDLLPPILIKKFLSYARQELNPVLNEDASNAVLRYFLELKGSCNLDEDVSSQIGAG--------- 755
            ||:   .::|.:::||...:.|.|:|:||.|::..::.::           :||:.
Mouse   681 LDM---AVLKDYIAYAHSTIMPRLSEEASQALIEAYVNMR-----------KIGSSRGMVSAYPR 731

  Fly   756 QLLAIIHLSQARARLDLSHVVSPQHVRDVIALLTESITQTS 796
            ||.::|.|::|.|::..|:.|....|.:...|..|::.|::
Mouse   732 QLESLIRLAEAHAKVRFSNKVEAIDVEEAKRLHREALKQSA 772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rec	NP_001262615.1	RNR_PFL	<117..200	CDD:299130	16/102 (16%)
		MCM	243..792	CDD:214631	136/589 (23%)
		P-loop_NTPase	468..606	CDD:304359	45/143 (31%)
Mcm4	NP_032591.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..71		17/58 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	90..121		2/30 (7%)
		MCM_N	165..286	CDD:291233	23/156 (15%)
		MCM	266..769	CDD:214631	136/591 (23%)
		P-loop_NTPase	504..643	CDD:304359	45/143 (31%)
		Arginine finger	641..644		0/2 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820