Protein Alignment rec and Mcm2

DIOPT Version :10

• Sequence 1: NP_732072.1
• Gene: rec / 49241
• FlyBaseID: FBgn0003227
• Length: 885
• Species: Drosophila melanogaster
• Sequence 2: NP_032590.2
• Gene: Mcm2 / 17216
• MGIID: 105380
• Length: 904
• Species: Mus musculus
• Alignment Length: 719
• Identity: 157/719 - (21%)
• Similarity: 295/719 - (41%)
• Gaps: 165/719 - (22%)

  Fly   167 KSDAQLKEVWPSLSEDIREHPLRTLGTLSLAMHTVVVNHQLD----------------------C 209
            :.|.::.|...:| ||::.|.:|.  .:|:|...:.::|:..                      |
Mouse   162 EEDEEMIESIENL-EDLKGHSVRE--WVSMAGPRLEIHHRFKNFLRTHVDSHGHNVFKERISDMC 223

  Fly   210 NDSTTAMVSTPEQ---------YVLPT---------------------PR----VRKIYARPDDF 240
            .::..::|...|.         |.||.                     |:    ...|:.|....
Mouse   224 KENRESLVVNYEDLAAREHVLAYFLPEAPAELLQIFDEAALEVVLAMYPKYDRITNHIHVRISHL 288

  Fly   241 VPVESIEGISHSRVDTLFSIRGFVSNVGEPSYSLTWQAFRCSRCQMEIAMRQRGTF------QPR 299
            ..||.:..:....::.|....|.|::.......|:...:.||:|...:     |.|      :.:
Mouse   289 PLVEELRSLRQLHLNQLIRTSGVVTSCTGVLPQLSMVKYNCSKCNFVL-----GPFCQSQNQEVK 348

  Fly   300 PYQCKRSECVARDEF-VPLRSSPYTRLSIRQIIRVEESSLNLVHDFETSMPAEMDVELRHDLVDA 363
            |..|  .||.:...| :.:..:.|...   |.||::||...:.   ...:|...|..|..||||:
Mouse   349 PGSC--PECQSAGPFEINMEETIYQNY---QRIRIQESPGKVA---AGRLPRSKDAILLADLVDS 405

  Fly   364 VRVGQEVVVTGILKLQELGDDTTTGDTSNQMQPY-----LKAVSIRDASSIKREFSERDLEAIVM 423
            .:.|.|:.:|||......|    :.:|:|....:     ...|:.:|......|.::.|::.|..
Mouse   406 CKPGDEIELTGIYHNNYDG----SLNTANGFPVFATIILANHVAKKDNKVAVGELTDEDVKMITG 466

  Fly   424 INAEPNSFKLLVQSIAPEVYGHELPKAACLLSLLGGK----GAETEA---INVLLVGDPGIGKTK 481
            ::.:....:.:..||||.:||||..|....|:|.||:    |.:.:.   |||||.||||..|::
Mouse   467 LSKDQQIGEKIFASIAPSIYGHEDIKRGLALALFGGEPKNPGGKHKVRGDINVLLCGDPGTAKSQ 531

  Fly   482 ILQSCAQIAERGAHVSGKRGAQSAQQLGVT-FAGRN----KRVLQAGSLMMASGGGHCTLDDVDK 541
            .|:...:::.|....:|    |.|..:|:| :..|:    :..|:||:|::|. .|.|.:|:.||
Mouse   532 FLKYIEKVSSRAIFTTG----QGASAVGLTAYVQRHPVSREWTLEAGALVLAD-RGVCLIDEFDK 591

  Fly   542 LASKQAVLL-QCLQSEEVNLPLAGAFASFPAQPSVIACANPQRGQYDEGRYLLQNINISPSLLRE 605
            :..:....: :.::.:.:::..||...|..|:.:|||.|||..|:||......:|::::..::..
Mouse   592 MNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFSENVDLTEPIISR 656

  Fly   606 FHLVYILLD--KPSERDM----SLTAHVRALHAGARKRARIAARYALKPKMSDSMCEVSLNVPAA 664
            |.::.::.|  .|.:.:|    .:.:|||. |...:|...:.....|:|.|.::.
Mouse   657 FDVLCVVRDTVDPVQDEMLARFVVGSHVRH-HPSNKKDEGLTNGGTLEPAMPNTY---------- 710

  Fly   665 GKDDDTIKTEDDNDSIMQQDYDLDKRLEVLPEEGDLDLLPPILIKKFLSYARQELNPVLNEDASN 729
                                     .:|.||:|         ::||::.||::.:.|.||:...:
Mouse   711 -------------------------GVEPLPQE---------VLKKYIIYAKERVRPKLNQMDQD 741

  Fly   730 AVLRYFLELKGSCNLDEDV---SSQIGAGQLLAIIHLSQARARLDLSHVVSPQHVRDVIALLTES 791
            .|.|.:.:|:     .|.:   |..|....:.::|.:::|.||:.|...|....|...|.::.||
Mouse   742 KVARMYSDLR-----KESMATGSIPITVRHIESMIRMAEAHARMHLRDYVMEDDVNMAIRVMMES 801

  Fly   792 ITQT 795
            ...|
Mouse   802 FIDT 805

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rec	NP_732072.1	Mcm2	177..799	CDD:440854	155/709 (22%)
		MCM8	433..791	CDD:350665	93/379 (25%)
		MCM8_WHD	819..883	CDD:439328
Mcm2	NP_032590.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..166		1/3 (33%)
		Interaction with KAT7. /evidence=ECO:0000269|PubMed:11278932	2..257		16/97 (16%)
		Interaction with DNJC9. /evidence=ECO:0000250|UniProtKB:P49736	61..130
		MCM2_N	72..182	CDD:403724	6/20 (30%)
		MCM_N	197..287	CDD:464206	10/89 (11%)
		MCM	291..803	CDD:214631	137/583 (23%)
		Arginine finger	655..658		0/2 (0%)