DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rec and mcm9

DIOPT Version :9

Sequence 1:	NP_001262615.1	Gene:	rec / 49241	FlyBaseID:	FBgn0003227	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	XP_002932153.1	Gene:	mcm9 / 100490403	XenbaseID:	XB-GENE-949288	Length:	1126	Species:	Xenopus tropicalis

Alignment Length:	777	Identity:	169/777 - (21%)
Similarity:	299/777 - (38%)	Gaps:	217/777 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 FLRPENYAAPEDGLQVQSIAVDNPRAYSGWRLYFLREKYEEGN-ELATRIMAVEAYYQRNPHTFD 149
            :|.||..|..  |...:|..:::.:....   ..|.||||:.: .|....|.:   ::.|....:
Frog     2 YLSPEQVALV--GQVFESFVLEHHQKEIA---QILTEKYEDAHYSLVVNAMTL---FEANMEIGE 58

  Fly   150 FVMIRDRGFFPLCAAGIKSDAQLKEVWPSLSEDIREHPLRTLGTLSLAMHTVVVNHQLDCNDSTT 214
            :.     ..||            .||.|.....:|...:..|.:.| ...|:|:.......  .|
Frog    59 YF-----NAFP------------NEVLPIFDNALRRAAMSFLQSCS-EKQTLVMKQNFHAR--IT 103

  Fly   215 AMVSTPEQYVLPTPRVRKIYARPDDFVPVESIEGISHSRVDTLFSIRGFV---SNVGEPSYSLTW 276
            .:...||......||.|                .:.|     ..|:.|.|   |.|....|.
Frog   104 GLPVCPELTREHIPRTR----------------DVGH-----FLSVTGTVIRTSLVKVLEYE--- 144

  Fly   277 QAFRCSRCQMEIAMR----QRGTFQPRPYQCKRSE--------CVARDEFVPLRSSPYTRLSIRQ 329
            |.|.|::|:..:.::    |..||:| |..|...|        |:: |...|.....|..:.|::
Frog   145 QDFMCNKCKHVVTVKADFEQYYTFKP-PITCSNEEGCNSSKFTCLS-DSSTPASCRDYQEIKIQE 207

  Fly   330 IIRVEESSLNLVHDFETSMPAEMDVELRHDLVDAVRVGQEVVVTGIL--KLQELGDDTTTGDTSN 392
              :|:..|:.       |:|..|.|.|..||||:.:.|.:|.|.|::  :.:.|..||..
Frog   208 --QVQRLSVG-------SIPRSMIVVLEDDLVDSCKSGDDVTVYGVVMQRWKPLYIDTRC----- 258

  Fly   393 QMQPYLKA--VSIRDA--------SSIKRE---FSERDLEAIVMINAEPNSFKLLVQSIAPEVYG 444
            .::..|||  :::.:.        ..:::|   |.|:      ..|:.......::.|:.|:|:|
Frog   259 DLEIVLKANYIAVNNEQPCGVVINEEVRKEYEGFWEK------YRNSPLEGRNEILASLCPQVFG 317

  Fly   445 HELPKAACLLSLLGG----KGAETEA---INVLLVGDPGIGKTKILQSCAQIAERGAHVSGKRGA 502
            ..:.|.|..:.|.||    ..|.|..   .::|||||||.||::.|:...:|..|....:|
Frog   318 MFVVKLAVAMVLAGGVQRIDSAGTRVRGESHLLLVGDPGTGKSQFLKYAVKITPRSVLTAG---- 378

  Fly   503 QSAQQLGVTFAGRNKRV--------LQAGSLMMASGGGHCTLDDVDKLASKQAVLL-QCLQSEEV 558
                 :|.|.||.....        |:||:|::|. ||.|.:|:.:.:.......: :.::.:.:
Frog   379 -----IGSTSAGLTVTAVKDSGEWNLEAGALVLAD-GGLCCIDEFNSIKEHDRTSIHEAMEQQTI 437

  Fly   559 NLPLAGAFASFPAQPSVIACANPQRGQYDEGRYLLQNINISPSLLREFHLVYILLDKPSERDMSL 623
            ::..||.......:.:::|..|| :||||....:..|:.::..||..|.||.:|||..:| |..
Frog   438 SVAKAGLVCKLNTRTTILAATNP-KGQYDPEESISVNVALASPLLSRFDLVLVLLDTKNE-DWD- 499

  Fly   624 TAHVRALHAGARKRARIAARYALK----PKMSDSMCEVSLNVPAAGKDDDTIKTEDDNDSIMQQD 684
                           ||.:.:.|:    |:.||.:
Frog   500 ---------------RIISSFILESKGCPRKSDKL------------------------------ 519

  Fly   685 YDLDKRLEVLPEEGDLDLLPPILIKKFLSYARQELNPVLNEDASNAVLRYF-LELKGSCNLDEDV 748
            :.::|                  :|.:....: .|.|.:::||:..::||: |:.:.||......
Frog   520 WSMEK------------------MKTYFCLIK-NLQPKMSQDANVILVRYYQLQRQSSCRNAART 565

  Fly   749 SSQIGAGQLLAIIHLSQARARLDLSHVVSPQHVRDVIALLTESITQTSLKEGSSRQGTRGGG 810
            :.::    |.::|.|::|.|||....||:.:          ::||..|:.|.|.:.|...||
Frog   566 TIRL----LESLIRLAEAHARLMYRDVVTTE----------DAITVVSIMESSMQGGALLGG 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rec	NP_001262615.1	RNR_PFL	<117..200	CDD:299130	16/83 (19%)
		MCM	243..792	CDD:214631	131/599 (22%)
		P-loop_NTPase	468..606	CDD:304359	38/146 (26%)
mcm9	XP_002932153.1	MCM_N	15..104	CDD:379644	19/114 (17%)
		MCM_OB	118..244	CDD:379946	39/160 (24%)
		MCM9	306..604	CDD:350666	87/388 (22%)
		NadA	<808..871	CDD:382005
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920