DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rec and mcmdc2

DIOPT Version :9

Sequence 1:	NP_001262615.1	Gene:	rec / 49241	FlyBaseID:	FBgn0003227	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_001311369.1	Gene:	mcmdc2 / 100150056	ZFINID:	ZDB-GENE-030131-2568	Length:	674	Species:	Danio rerio

Alignment Length:	717	Identity:	156/717 - (21%)
Similarity:	245/717 - (34%)	Gaps:	238/717 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   208 DCNDSTTAMVSTPEQYVLPTPRVRKIY-----ARPDDFVPVESIEG--ISHSRVD--TLFSIRGF 263
            ||||...|.            ::..:|     ..|.|.:.::::.|  |.|..:.  :||....|
Zfish    27 DCNDFKGAQ------------QMEAVYRFSLDVNPSDVLQLDALLGDCILHDPIKAVSLFQSVCF 79

  Fly   264 VS----------------NV--------GEPSYSLTWQAFRCSRCQME--------IAMRQRGTF 296
            :|                ||        ..|:|.|....|......|.        |||.:...:
Zfish    80 LSIKTLSLIDHIETESQVNVVLKPTHLPPFPNYCLDLSEFPRGYGPMRPLALQGLVIAMTRVTKY 144

  Fly   297 -QPRPYQCKRSEC--------------------VARDEFV------PLRSSPYTRL----SIRQI 330
             |...:.|....|                    ..|::|.      ||:....:|:    .:.::
Zfish   145 TQGARFLCSEDACPCSRGFHHIRVHAPGATESATVRNDFTCFLCFSPLKEDVKSRVLGEKQLVEL 209

  Fly   331 IRVEESSLNLVHDFETSMPAEMDVE-----LRHDLVDAVRVGQEVVVTGILKLQELGDDTTTGDT 390
            |.|....:..|||     ||.:..:     ||.:|.:::|:|....|.||........:.|....
Zfish   210 IHVRAVDVLGVHD-----PASLRYQSVTLFLRDELCNSMRIGHLYRVVGIPAHVHQWPNVTWSVE 269

  Fly   391 SNQMQPYLKAVSIRDASSIKREF---------SERDLEAIVMINAEPNSFKLLVQSIAPEVYGHE 446
            :..:||::.    :..|.:...|         |.....|||     .|||...|  |.|.:|  .
Zfish   270 ACSVQPWIP----KCPSLVSNNFQNLHTASACSPWRFAAIV-----ANSFGSPV--IPPGLY--N 321

  Fly   447 LPKAACLLSLLGGKGAETE-------AINVLLVGDPGIGKTKILQSCAQIAERGAH--VSGKRGA 502
            ..|...|||||     :||       .::||.:....:...::::...|:|.||.|  ::|:..|
Zfish   322 TLKLGLLLSLL-----QTEDNTDSPNHLDVLALTSDSLIIDRLMRYSLQLASRGIHHALTGELLA 381

  Fly   503 Q-SAQQLGVTFAGRNKRVLQAGSLMMASGGGHCTLDDVDKLASKQAVLLQ-CLQSEEVNLPL-AG 564
            . |..:.|.:.|.     :.|||.::|| ||.|.|.|:......:..:|| .|:|..|::.: |.
Zfish   382 SLSRDEHGASTAN-----IHAGSALLAS-GGVCLLGDLTCYKKDKMDMLQSALESRTVSVFIPAK 440

  Fly   565 AFA-------SFP-----------AQPS--VIACANPQRGQYDEGRYLLQNINISPSLLREFHLV 609
            .:.       |||           |.||  ...|.|...|..:.|...||       |...|.||
Zfish   441 KYGDDTDQQLSFPIQCNFWALVDIASPSKRTARCDNALLGSGEMGSVPLQ-------LTGAFGLV 498

  Fly   610 YILLDKPSERD-MSLTAHVRALHAGARKRARIAARYALKPKMSDSMCEVSLNVPAAGKDDDTIKT 673
            ....:..:... :|:|.|              ..|.|:.|                        .
Zfish   499 VQCRETSNNHPILSMTVH--------------TLRQAMSP------------------------G 525

  Fly   674 EDDNDSIMQ---QDYDLDKRLEVLPEEGDLDLLPPILIKKFLSYARQELNPVLNEDASNAVLRYF 735
            |....:.||   |||                       |:.|::||| |...|:.||...:..|:
Zfish   526 EPLYPACMQFTTQDY-----------------------KELLAHARQ-LKVDLSLDAERMIHGYY 566

  Fly   736 LELKGSCNLDEDVSSQIGAGQLLAIIHLSQARARLDLSHVVSPQHVRDVIALLTESITQTSLKEG 800
            :   ||.....|.:.:.....:..:|.|:||.|:|.|...|..:.....:.|...|:|   ||.|
Zfish   567 M---GSRRFRSDSTQRSSVTSIKLLIALAQAHAKLSLRTEVLEEDAVIAVLLCESSVT---LKHG 625

  Fly   801 SS 802
            :|
Zfish   626 AS 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rec	NP_001262615.1	RNR_PFL	<117..200	CDD:299130
		MCM	243..792	CDD:214631	142/665 (21%)
		P-loop_NTPase	468..606	CDD:304359	41/162 (25%)
mcmdc2	NP_001311369.1	MCM	<359..619	CDD:330922	76/337 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11630
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100