DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rec and mcm3l

DIOPT Version :9

Sequence 1:	NP_001262615.1	Gene:	rec / 49241	FlyBaseID:	FBgn0003227	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_001164539.1	Gene:	mcm3l / 100147915	ZFINID:	ZDB-GENE-040121-2	Length:	807	Species:	Danio rerio

Alignment Length:	490	Identity:	131/490 - (26%)
Similarity:	222/490 - (45%)	Gaps:	70/490 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   348 MPAEMDVELRHDLVDAVRVGQEVVVTGILKLQELGDDTTTGDTSNQMQPYLKAVSIRDAS-SIKR 411
            :|..:|:....||||.|:.|..|.:.|:.:.......   |.||...:..|.|.:::..| .|..
Zfish   211 LPRSVDIIANDDLVDRVKPGDRVQIVGVYRCLPAKQG---GFTSGTFRTILLANNVKLMSKEIVP 272

  Fly   412 EFSERDLEAIVMINAEPNS---FKLLVQSIAPEVYGHELPKAACLLSLLGGKGAETE-------A 466
            .||..|:..|... .:.:|   |:.|.:|:||.::|||..|.|.|..||||.....|       .
Zfish   273 TFSGDDVAKIKKF-CKAHSKDVFEQLSRSLAPSIHGHEYIKKAILCLLLGGNETNLENGTRIRGD 336

  Fly   467 INVLLVGDPGIGKTKILQSCAQIAERGAHVSGKRGAQSAQQLGVTFA-----GRNKRVLQAGSLM 526
            ||:||:|||.:.|:::|:.....|.|....:| ||:..   :|:|.|     ...:|.|:||:::
Zfish   337 INILLIGDPSVAKSQLLRYVLFTAPRAIPTTG-RGSSG---VGLTAAVTTDQETGERRLEAGAMV 397

  Fly   527 MASGGGHCTLDDVDKLAS-KQAVLLQCLQSEEVNLPLAGAFASFPAQPSVIACANPQRGQYDEGR 590
            :|..|..| :|:.||::. .:..:.:.::...|.:..||..|...|:.||:|.|||..|:||:.:
Zfish   398 LADRGVVC-IDEFDKMSDMDRTAIHEVMEQGRVTISKAGIQARLNARCSVLAAANPVYGRYDQYK 461

  Fly   591 YLLQNINISPSLLREFHLVYILLDK-PSERDMSLTAHVRALHAGARKRARIAARYALKPKMSDSM 654
            ..::||.:..|||..|.|::|:||: ..:.|..::.||..:|   |.||...|.....|
Zfish   462 TPMENIGLQDSLLSRFDLLFIVLDQMDPDSDKEISEHVLRMH---RYRAPGEAEGTAMP------ 517

  Fly   655 CEVSLNVPAAGKDDDTIKTEDDN-DSIMQQDYDL------------DKRLEVLPEEGDLDLLPPI 706
                     .|...|...|||.| ....:|:..:            .||.:::..|
Zfish   518 ---------LGSTVDVFATEDPNITEASEQELQIYEKKDNVLHGHRKKREKIVTME--------- 564

  Fly   707 LIKKFLSYARQELNPVLNEDASNAVLRYFLELKG--SCNLDEDVSSQIGAGQLLAIIHLSQARAR 769
            .|:|::..|:. :.|||.::||:.:...:..|:.  ..|.|...:..:.|..|..:|.||.|.|:
Zfish   565 FIRKYIHVAKL-VKPVLTQEASDYIAEEYSRLRSHDQVNSDSARTMPVTARALETMIRLSTAHAK 628

  Fly   770 LDLSHVVSPQHVRDVIALLTESITQTSLKEGSSRQ 804
            ..:|..|........:.|:..:..:..|::...|:
Zfish   629 ARMSKTVDLADAEAALELMQFAYFKKILEKVKKRK 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rec	NP_001262615.1	RNR_PFL	<117..200	CDD:299130
		MCM	243..792	CDD:214631	129/476 (27%)
		P-loop_NTPase	468..606	CDD:304359	45/143 (31%)
mcm3l	NP_001164539.1	MCM_N	29..127	CDD:291233
		MCM	107..652	CDD:214631	129/477 (27%)
		P-loop_NTPase	338..477	CDD:304359	45/143 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910