DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mod(mdg4) and ab

DIOPT Version :9

Sequence 1:	NP_788698.1	Gene:	mod(mdg4) / 49228	FlyBaseID:	FBgn0002781	Length:	610	Species:	Drosophila melanogaster
Sequence 2:	NP_476562.1	Gene:	ab / 34560	FlyBaseID:	FBgn0264442	Length:	904	Species:	Drosophila melanogaster

Alignment Length:	692	Identity:	146/692 - (21%)
Similarity:	246/692 - (35%)	Gaps:	203/692 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EQFSLCWNNFNTNLSAGFHESLCRGDLVDVSLAAEGQIVKAHRLVLSVCSPFFRKMFTQMPSNTH 69
            :.::|.||:|.:::.:.|.......|.|||:||.:.:...||::|||.|||:||::....|.. |
  Fly    76 QHYALKWNDFQSSILSSFRHLRDEEDFVDVTLACDERSFTAHKVVLSACSPYFRRLLKANPCE-H 139

  Fly    70 AIVFLNNVSHSALKDLIQFMYCGEVNVKQDALPAFISTAESLQIKGLTD-NDPAPQPPQESSPPP 133
            .||.|.:|....:::|:.|||.|||||..:.||.|:.||..|||:||.| |...|.....|:
  Fly   140 PIVILRDVRCDDVENLLSFMYNGEVNVSHEQLPDFLKTAHLLQIRGLADVNGGYPYSKALSA--- 201

  Fly   134 AAPHVQQQQIPAQRVQRQQPRASARYKIETVDDGLGDEKQSTTQIVI-------QTTAA------ 185
            |..|        .........:|:...:...::...:..:|:....|       ||:||
  Fly   202 ALSH--------NSSNNNNNNSSSNNSLSNNNNNNNNNAESSNHNKISSYLSPNQTSAACNNSSN 258

  Fly   186 ------------------------------------PQATIVQQQQPQQAAQQIQSQQLQTGTTT 214
                                                |..|.........||..:.:........|
  Fly   259 SNSNNHSSSHNNSSSNNISGSLNSSLNSPFSAPQIPPPVTASSAAAAAAAAASLTAAVAAAAAAT 323

  Fly   215 TATLVSTNKRSAQRSSLTP------ASSSAGVKR------SKTSTSAN-VMDPLDSTTETGATTT 266
            .|:..|::..::.::|.||      |||:|...|      ||.|:|.: .|..::.:.::..|.
  Fly   324 AASAGSSSSAASGQTSGTPAIQELKASSAASPVRNPNPNPSKASSSNHWDMGEMEGSRKSHLTP- 387

  Fly   267 AQLVPQQITVQTSVVSAAEAKLHQQSPQQVRQEEAEYIDLPMELP---------TKSEPDYSEDH 322
                |.|..::::.:..|:   |..||:::.        |..|.|         .:|..|.|:|.
  Fly   388 ----PPQKRIKSADLFRAQ---HGISPERLL--------LDREFPVAGQHPLTRNRSGRDTSKDR 437

  Fly   323 -----------GDAAGDAEGTYVE-DDTYGDMRYDDSYFTENEDAGNQTAANTSGGGVTATTSKA 375
                       |.|..::.|.... ....|....:||..::.|.:..       |.|....|...
  Fly   438 ERNLELRESLLGQALENSNGQQANPKHELGQSAGEDSNSSDTEPSDR-------GDGQHDGTLDG 495

  Fly   376 VVKQQSQNYSESSFVDTSGDQGNTEAQAATSASATKIPPRKRGRPKTKVEDQTPKPKLLEKLQAA 440
            :..|:|.:: .::|:...|..|.....:..::....   |:....:.:..|..|.||..:..::|
  Fly   496 IDNQRSHSF-PNAFLGLQGIPGLLPGPSGINSDFVS---RRSLEMRVRATDPRPCPKCGKIYRSA 556

  Fly   441 -TLNEEASEPAVYASTTKGGVKLIFNGHLFKFSFRKADYSVFQCCYREH-GEECKVRVVCDQKRV 503
             ||.....:    ..|...|.:.:..|     :..|:..|:.....|:| |...|      ...|
  Fly   557 HTLRTHLED----KHTVCPGYRCVLCG-----TVAKSRNSLHSHMSRQHRGISTK------DLPV 606

  Fly   504 FPYEGEHVHFMQASDKSCLPSQFMP-------GESGVISSLSPSKELLMKNTT------------ 549
            .|                :||.|.|       .::||  .:||::.....:.|
  Fly   607 LP----------------MPSAFDPELASRLLAKAGV--KISPAELRARASPTGGSGSSGGGGGG 653

  Fly   550 -----KLE-------EADDKEDEDFEEFEIQEIDEIELDEPE 579
                 ||:       ..||.||.|              |:||
  Fly   654 GSSQAKLDLSNASGGPMDDAEDSD--------------DDPE 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mod(mdg4)	NP_788698.1	BTB	22..118	CDD:279045	42/95 (44%)
		BTB	33..118	CDD:197585	39/84 (46%)
		FLYWCH	452..512	CDD:282369	11/60 (18%)
ab	NP_476562.1	BTB	93..189	CDD:279045	42/96 (44%)
		BTB	104..189	CDD:197585	39/85 (46%)
		zf-Di19	545..597	CDD:283297	12/60 (20%)
		C2H2 Zn finger	546..567	CDD:275371	5/24 (21%)
		C2H2 Zn finger	575..596	CDD:275371	4/25 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	68	1.000	Domainoid score	I9675
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	4.010