DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mod(mdg4) and CG12236

DIOPT Version :9

Sequence 1:	NP_788698.1	Gene:	mod(mdg4) / 49228	FlyBaseID:	FBgn0002781	Length:	610	Species:	Drosophila melanogaster
Sequence 2:	NP_727050.1	Gene:	CG12236 / 31523	FlyBaseID:	FBgn0029822	Length:	553	Species:	Drosophila melanogaster

Alignment Length:	498	Identity:	140/498 - (28%)
Similarity:	212/498 - (42%)	Gaps:	117/498 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MADDEQFSLCWNNFNTNLSAGFHESLCRGDLVDVSLAAEGQIVKAHRLVLSVCSPFFRKMFTQMP 65
            ||..:|:||.|||:..:|:..........|.|||||..:|:.:|||::|||.||.:|:::|.:.|
  Fly     1 MATTQQYSLRWNNYLRHLTYSLDNHRLNDDFVDVSLCVDGRRIKAHKVVLSSCSSYFKEIFKENP 65

  Fly    66 SNTHAIVFLNNVSHSALKDLIQFMYCGEVNVKQDALPAFISTAESLQIKGLTDNDPAPQPPQESS 130
             :.|.::....:....|..:|:|||.|||||:|:||.:|:.|||.|.::|||..:      :|..
  Fly    66 -HPHPVIIFKFIKFEDLNSIIEFMYQGEVNVQQEALQSFLQTAELLAVQGLTAEE------KEKP 123

  Fly   131 PPPAAPHV------------------QQQQ---------------IPA-------------QRVQ 149
            ..|.||.:                  ||||               |||             .:|.
  Fly   124 QIPVAPLISEHKLIKTIPSTIRAVNEQQQQVSNVAQAQTATQTIEIPAATLLQATNASQVPSQVV 188

  Fly   150 RQQPRASARYKIETVDDGLGDEKQSTTQ---IVIQTTAAPQATIVQQQQPQQAAQQIQSQQLQTG 211
            .....|:|..:::............|||   |.:|:...||....||||.||..||.|.||.|..
  Fly   189 AAAAAAAAAQQLQVQHQQQQHHHVQTTQIQHIQVQSAPPPQQQQQQQQQQQQQQQQQQQQQQQQS 253

  Fly   212 TTTTATLVSTNKRSAQRSSLTPASSSAGVKRSKTSTSANVMDPLDS--TTETGATTTAQLVPQQI 274
            .....|.|.|...:...:...||:||  ||:.|.:.|    |..|:  ||||        |...:
  Fly   254 QQQQTTPVQTQHLTITNAVALPAASS--VKKRKITFS----DDDDNMYTTET--------VDYAV 304

  Fly   275 TVQTSVVSAAEAKLHQQSPQQVRQEEAEYI--DLPMELPTKSEPDYSEDHGDAAGDAEGTYVEDD 337
            ..:.::|..||....:.:   |:.:..:||  ::...|...:.|..|:|...||......|..:
  Fly   305 KDEQTIVKTAEMTFLRGA---VKMDIPDYIVGEVDDRLSDGATPQTSQDATTAAAQNVAQYSSE- 365

  Fly   338 TYGDMRYDDSYFTENE-------DAGNQ-----------TAANTSG----------GGVTATT-- 372
                  |:  ..||:|       ||.|.           ||:.|.|          ||.:|||
  Fly   366 ------YE--ILTESEMEEKYQADADNAEIAIEMTRLLGTASGTPGAGSGQVMEDSGGGSATTGP 422

  Fly   373 SKAVVKQQSQNYSESSFVDTSGDQGN-TEAQAATSASATKIPP 414
            |..|...|.::.|::|..:.:...|: |.|:::.|.:....||
  Fly   423 STTVSVTQVKSDSKASGTNAALKPGSVTVARSSKSGATASAPP 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mod(mdg4)	NP_788698.1	BTB	22..118	CDD:279045	39/95 (41%)
		BTB	33..118	CDD:197585	37/84 (44%)
		FLYWCH	452..512	CDD:282369
CG12236	NP_727050.1	BTB	22..116	CDD:279045	38/94 (40%)
		BTB	33..116	CDD:197585	36/83 (43%)
		Herpes_capsid	<376..467	CDD:283714	23/90 (26%)
		C2H2 Zn finger	483..512	CDD:275371
		C2H2 Zn finger	514..535	CDD:275371
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	68	1.000	Domainoid score	I9675
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	50	1.000	Inparanoid score	I5472
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	5.060