Protein Alignment DDR2 and ddr-2

DIOPT Version :10

• Sequence 1: NP_006173.2
• Gene: DDR2 / 4921
• HGNCID: 2731
• Length: 855
• Species: Homo sapiens
• Sequence 2: NP_508572.1
• Gene: ddr-2 / 180622
• WormBaseID: WBGene00017381
• Length: 797
• Species: Caenorhabditis elegans
• Alignment Length: 871
• Identity: 280/871 - (32%)
• Similarity: 440/871 - (50%)
• Gaps: 114/871 - (13%)

Human     7 MLLVLFLL-LPILSSAKAQVNPAICRYPLGMSGGQIPDEDITASSQWS-ESTAAKYGRLDSEEGD 69
            |.|:|:|. :...|:....:....|.:.||||..:|.||.|:|||.:. :||..::.|...|.|.
 Worm     1 MKLLLYLFGVTFHSNTVVALELRECSHQLGMSNRKIRDEQISASSSFDLQSTGPQHARAHQESGS 65

Human    70 GAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKINYSRDG-TRWISWR 133
            |||||:..:.... ||:|||.......||.|.||||...|.|:|:|..:||.|.|.. ..|.|::
 Worm    66 GAWCPKNQINSLS-KEWLQISFSVDTVITSVETQGRFDDGRGMEYATAFKIQYWRPSLNAWASYK 129

Human   134 NRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRVELYGCVWLDGLVSYNAPA 198
            :....:.:..|::......:.|:..|:||.:|.:||::.:..||||||::||.:.|.||.||...
 Worm   130 DDFELETIPANNDTEHAIRRHLDRAIIARRIRIVPVSNSTRTVCMRVEVFGCPFDDSLVFYNVDQ 194

Human   199 GQQFVLPGGSIIYLNDSVYDGAVGYS--MTEGLGQLTDGVSGLDDFTQTHEYHVWPGYDYVGWRN 261
            |.   |..|  |..:|..|||.:..|  :|.|:|:|.||..|.::....|  |.|     ||||.
 Worm   195 GD---LQSG--ISYHDFSYDGNLANSPHLTGGIGKLYDGEVGKNNVFVNH--HKW-----VGWRR 247

Human   262 ESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFKEVQCYFRSEASEWEPNAISFPLVLDD 326
            :  .||.:::.|||..:||.:.:.:|.:|.|.|..|.|......|.....::....:.|....|.
 Worm   248 K--RNGNVKLAFEFSELRNISGILIHTSNEFKKSAKAFSSATVLFSINGKDFSDTIVHFNNPEDT 310

Human   327 VNPSARFVTVPLHHRMASAIKCQYHFA--DTWMMFSEITFQSDAAMYNNSEALPTSPMAP--TTY 387
            .:...|::.:|:::|:|...|.:.:|.  ..|:..||:.|:|:   :.|.|.|....:.|  .:|
 Worm   311 ESEVPRWIRIPVNNRIAKVAKIRLNFGTDSDWLFISEVNFESN---HTNIELLNDDVVIPDSVSY 372

Human   388 DPMLKVDDSNTRILIGCLVAIIFILLAIIVI-ILWRQFWQKMLEKASRRMLDDEMTVSLSL---- 447
            ..:.:.|| .|.:....:...:|:::|:|:: :|:|:  ::...|||....:.:..:.|::
 Worm   373 FSVTEHDD-GTSMFAFIIFFFMFLIVAVIILTVLYRK--REYRVKASSPSPNAKREILLTIDGNT 434

Human   448 ------PSDSSMFNNNRSSSPSEQGSNSTYDRIFPLRPDYQEPSRLIRKLPEFAPGEEESGCSGV 506
                  ||...|..:|..::..|:...|      |:..||.||              :.|.||.|
 Worm   435 IKHHVSPSTYQMARDNLQNALIEKMPMS------PIISDYAEP--------------DISVCSDV 479

Human   507 VKPVQPSGPEGVPHYAEADIVNLQGVTG-------GNTYSVPAVTMDLLSGKDVAVEEFPRKLLT 564
            .                |:...|.|:.|       .|..|......|........:.|..|..|.
 Worm   480 T----------------ANTPLLYGIDGPYDTQKRSNPLSSMVKYSDYGEVYCTTLPEIARDKLI 528

Human   565 FKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIM 629
            ...::|:|:||||.||::|..:                  ||||.|...:..: ...|.:||:::
 Worm   529 CVSRIGQGEFGEVDLCQLENRK------------------VAVKKLHGISQAD-EFSFHREIRVL 574

Human   630 SRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQI 694
            ..||.||::.::.||....|:..|.||||||||..::.::.          |:..:....:.||:
 Worm   575 GSLKHPNVVEVVGVCTIQKPILCIMEYMENGDLKSYILKNP----------TIQTSQCISICTQL 629

Human   695 ASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESI 759
            |:|:.||.|.||||||:|.|||||.....:|||||||:|:|||.:||:::|:.|||||||:||::
 Worm   630 AAGLAYLESCNFVHRDIAARNCLVDGEGNVKIADFGMARSLYSQEYYKVEGKFVLPIRWMAWEAL 694

Human   760 LLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSV 824
            |||||:||||||.||||:||.|:.|.|:|||.::|:.|:||..........:..|.:|.:||..:
 Worm   695 LLGKFSTASDVWGFGVTMWEIFSLCSEKPYSDMTDDDVVENLQSMSSTGSLKQVLSRPRMCPSKL 759

Human   825 Y-KLMLSCWRRDTKNRPSFQEIHLLL 849
            | :.:|.||..::..||||:.:||.|
 Worm   760 YNEQILPCWNYESSRRPSFENVHLHL 785

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DDR2	NP_006173.2	FA58C	32..184	CDD:238014	57/153 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	452..471		4/18 (22%)
		PTKc_DDR2	557..851	CDD:270677	121/294 (41%)
ddr-2	NP_508572.1	FA58C	29..180	CDD:330301	57/151 (38%)
		TyrKc	527..785	CDD:197581	118/286 (41%)