DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ROR2 and ror2

DIOPT Version :9

Sequence 1:	NP_004551.2	Gene:	ROR2 / 4920	HGNCID:	10257	Length:	943	Species:	Homo sapiens
Sequence 2:	XP_021327888.1	Gene:	ror2 / 561183	ZFINID:	ZDB-GENE-060427-5	Length:	939	Species:	Danio rerio

Alignment Length:	914	Identity:	669/914 - (73%)
Similarity:	770/914 - (84%)	Gaps:	16/914 - (1%)

- Green bases have known domain annotations that are detailed below.

Human    32 SGEVEVLDPNDPLGPLDGQDGPIPTLKGYFLNFLEPVNNITIVQGQTAILHCKVAGNPPPNVRWL 96
            |.|:|.|        .:.|.|.:||.:||:|.|||..|||||||||||.|||||||:|.|::|||
Zfish    40 SEEIEAL--------AEAQSGGLPTPEGYYLEFLEQPNNITIVQGQTATLHCKVAGHPRPSIRWL 96

Human    97 KNDAPVVQEPRRIIIRKTEYGSRLRIQDLDTTDTGYYQCVATNGMKTITATGVLFVRLGPT-HSP 160
            |||||||||..|:.|||||.||:||||||||||||||||||||.:|.|:|||||:||||.| .||
Zfish    97 KNDAPVVQEQGRVSIRKTEAGSKLRIQDLDTTDTGYYQCVATNSIKVISATGVLYVRLGNTGQSP 161

Human   161 NHNFQDDYHEDGFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSTHLSDQCSQ 225
            .|..:|..||.||||||||||||||||||:|||:|||||||.|||||||||||||||.||||||:
Zfish   162 AHGAEDSTHEKGFCQPYRGIACARFIGNRSIYVESLQMQGESENRITAAFTMIGTSTQLSDQCSE 226

Human   226 FAIPSFCHFVFPLCDARSRTPKPRELCRDECEVLESDLCRQEYTIARSNPLILMRLQLPKCEALP 290
            |||||||::|||||:..:|.|:.|:|||||||.||:|||..|||||||||||||:|:||.|..||
Zfish   227 FAIPSFCYYVFPLCEEGTRGPRRRQLCRDECEALENDLCNAEYTIARSNPLILMQLELPVCSLLP 291

Human   291 MPESPDAANCMRIGIPAERLGRYHQCYNGSGMDYRGTASTTKSGHQCQPWALQHPHSHHLSSTDF 355
            .|.||||::|:|||:|.:.....|.|||.||.:|:||.|.||||.|||||:.|:|||||||..::
Zfish   292 HPGSPDASSCIRIGLPPQYSPPDHSCYNESGGNYKGTVSVTKSGFQCQPWSAQYPHSHHLSPIEY 356

Human   356 PELGGGHAYCRNPGGQMEGPWCFTQNKNVRMELCDVPSCSPRDSSKMGILYILVPSIAIPLVIAC 420
            |:|.|||.:|||||||||.|||||.:.|||::|||:|.|:|.:..|..:||||:||:|.|||.||
Zfish   357 PQLRGGHNFCRNPGGQMESPWCFTLDPNVRVDLCDIPPCNPPEKMKKELLYILIPSVATPLVFAC 421

Human   421 LFFLVCMCRNKQKASASTPQRRQLMASPSQDMEMPLINQHK-QAKLKEISLSAVRFMEELGEDRF 484
            ||||:||||||||.|..||.||||.|||||:||:||:|||| ||||:|::|||||||||||||||
Zfish   422 LFFLICMCRNKQKESVDTPTRRQLTASPSQEMELPLLNQHKHQAKLRELNLSAVRFMEELGEDRF 486

Human   485 GKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVVCLLGVVTKDQPL 549
            ||||||||:|.|||||||.|||||:|||.|||||||||||||||:||||||:||||||:||:||:
Zfish   487 GKVYKGHLYGTAPGEQTQVVAIKTVKDKDEGPLREEFRHEAMLRSRLQHPNIVCLLGVITKEQPM 551

Human   550 SMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHK 614
            ||||||...||||||||||||||||||:|||:||||.||..||:|:|.|:|||||||||||||||
Zfish   552 SMIFSYSGQGDLHEFLVMRSPHSDVGSSDDDKTVKSTLEQADFLHIVTQVAAGMEYLSSHHVVHK 616

Human   615 DLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYG 679
            |||.||:||.|||||||.|||||||||:||||||:|.|..|||||:||||:|||||.||||||||
Zfish   617 DLAARNILVCDKLNVKILDLGLFREVYSADYYKLMGASPFPIRWMSPEAILYGKFSTDSDIWSYG 681

Human   680 VVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHS 744
            |||||:||||||||||||||||:||:||||||.||||||||:|.:|:|||||||||||||||||:
Zfish   682 VVLWEIFSYGLQPYCGYSNQDVIEMVRNRQVLSCPDDCPAWIYTMMLECWNEFPSRRPRFKDIHA 746

Human   745 RLRAWGNLSNYNSSAQTSGASNTTQTSSLSTSPVSNVSNARYVGPKQKAPPFPQPQFIPMKGQIR 809
            |||.|.:|||||||||||||||||||||||||||||:||||||.|| |:.|||||||:.||||:|
Zfish   747 RLRTWESLSNYNSSAQTSGASNTTQTSSLSTSPVSNISNARYVSPK-KSSPFPQPQFVSMKGQMR 810

Human   810 PMVPPPQLYVPVNGYQPVPAYGAYLPNFYPVQIPMQMAPQQVPPQMVPKPSSHHSGSGSTSTGYV 874
            ||| |||||:|||||||:||| .||.||||:||||||.|||:.||||.|..||||||||||||||
Zfish   811 PMV-PPQLYIPVNGYQPMPAY-PYLQNFYPMQIPMQMPPQQMHPQMVAKAGSHHSGSGSTSTGYV 873

Human   875 TTAPSNTSMADRAALLSEGADDTQNAPEDGAQSTVQEAEEEEEGSVPETELLGDCDTLQVDEAQV 939
            ||||||.|..|:.||::|....|::...|||.   |:....|:.||||||||||.|:...::.::
Zfish   874 TTAPSNGSGTDKVALMNEDLKATEDDFADGAS---QKGLHHEDLSVPETELLGDNDSPHTEDNEI 935

Human   940 QLEA 943
            ..:|
Zfish   936 NSDA 939

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ROR2	NP_004551.2	I-set	64..152	CDD:254352	70/87 (80%)
		IGc2	75..141	CDD:197706	54/65 (83%)
		CRD_TK_ROR2	170..309	CDD:143577	106/138 (77%)
		KR	314..395	CDD:214527	53/80 (66%)
		PTKc_Ror2	466..749	CDD:270673	236/282 (84%)
		Pkinase_Tyr	473..746	CDD:285015	229/272 (84%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	757..796		33/38 (87%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	850..931		47/80 (59%)
ror2	XP_021327888.1	I-set	63..152	CDD:254352	70/88 (80%)
		CRD_FZ	171..307	CDD:321937	105/135 (78%)
		KR	314..395	CDD:238056	53/80 (66%)
		PTKc_Ror2	468..751	CDD:270673	236/282 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194327792
Domainoid	1	1.000	503	1.000	Domainoid score	I2716
eggNOG	1	0.900	-	-		E2759_KOG1026
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55831
Inparanoid	1	1.050	1394	1.000	Inparanoid score	I1143
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG48666
OrthoDB	1	1.010	-	-		D222671at33208
OrthoFinder	1	1.000	-	-		FOG0003730
OrthoInspector	1	1.000	-	-		oto42244
orthoMCL	1	0.900	-	-		OOG6_105406
Panther	1	1.100	-	-	LDO	PTHR24416
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3136
SonicParanoid	1	1.000	-	-		X2586
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	18	18.300