DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ROR2 and ror2

DIOPT Version :9

Sequence 1:	NP_004551.2	Gene:	ROR2 / 4920	HGNCID:	10257	Length:	943	Species:	Homo sapiens
Sequence 2:	NP_001015834.1	Gene:	ror2 / 548551	XenbaseID:	XB-GENE-491498	Length:	930	Species:	Xenopus tropicalis

Alignment Length:	931	Identity:	750/931 - (80%)
Similarity:	825/931 - (88%)	Gaps:	14/931 - (1%)

- Green bases have known domain annotations that are detailed below.

Human    14 CIPAVWAAAALLLSVSRTSGEVEVLDPNDPLGPLDGQDGPIPTLKGYFLNFLEPVNNITIVQGQT 78
            |.|..:..||:||:: :.|||:|:.|.|||||.:|..|....|.:||||.||||||||||||||.
Frog    13 CAPLGFIVAAILLAL-QASGEMEIPDLNDPLGQMDSHDRLGATPRGYFLTFLEPVNNITIVQGQA 76

Human    79 AILHCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSRLRIQDLDTTDTGYYQCVATNGMKT 143
            |.|||||:|||.|||:||||||||||||:||.||||:|||||||||||||||||||||||||:||
Frog    77 ATLHCKVSGNPLPNVKWLKNDAPVVQEPKRITIRKTDYGSRLRIQDLDTTDTGYYQCVATNGIKT 141

Human   144 ITATGVLFVRLGPTHSPNHNFQDDYHEDGFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITA 208
            ||||||||||||||:|||.|.|||||:||||||||||||||||||||||||||||||||||||||
Frog   142 ITATGVLFVRLGPTNSPNPNTQDDYHKDGFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITA 206

Human   209 AFTMIGTSTHLSDQCSQFAIPSFCHFVFPLCDARSRTPKPRELCRDECEVLESDLCRQEYTIARS 273
            ||||||||||||||||||||||||||||||||  .:|.||||||||||||||:|||||||.||||
Frog   207 AFTMIGTSTHLSDQCSQFAIPSFCHFVFPLCD--DQTSKPRELCRDECEVLENDLCRQEYNIARS 269

Human   274 NPLILMRLQLPKCEALPMPESPDAANCMRIGIPAERLGRYHQCYNGSGMDYRGTASTTKSGHQCQ 338
            ||||||:|.||.||.||:||||:||||||||||.|:|.||.|||||:|.||||:...||||||||
Frog   270 NPLILMQLHLPNCEELPLPESPEAANCMRIGIPVEKLNRYQQCYNGTGTDYRGSVIVTKSGHQCQ 334

Human   339 PWALQHPHSHHLSSTDFPELGGGHAYCRNPGGQMEGPWCFTQNKNVRMELCDVPSCSPRDSSKMG 403
            ||:.|.||||.|||.|.||:|||||||||||||||||||||.||:|||||||:|:|..||::||.
Frog   335 PWSNQVPHSHSLSSADHPEIGGGHAYCRNPGGQMEGPWCFTLNKHVRMELCDIPACRTRDNTKME 399

Human   404 ILYILVPSIAIPLVIACLFFLVCMCRNKQKASASTPQRRQLMASPSQDMEMPLINQHK-QAKLKE 467
            |||||||||||||||||.|||||||||||||||||||||||||||||||||||:|||| |.|:||
Frog   400 ILYILVPSIAIPLVIACFFFLVCMCRNKQKASASTPQRRQLMASPSQDMEMPLMNQHKQQPKVKE 464

Human   468 ISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQ 532
            |:||.||||||||||||||||||||||..||||||.|||||||||.|..|||||:||||:|:|||
Frog   465 INLSTVRFMEELGEDRFGKVYKGHLFGTTPGEQTQTVAIKTLKDKVEVALREEFKHEAMMRSRLQ 529

Human   533 HPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLVA 597
            |||:|||:|.|||:||:||:|||....|||||||||||||||||||||:||||.|||.||:|:|.
Frog   530 HPNIVCLIGTVTKEQPMSMVFSYSPLSDLHEFLVMRSPHSDVGSTDDDKTVKSTLEPTDFLHIVT 594

Human   598 QIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIRWMAPE 662
            |||||||:||||||||||||.|||||:|||:||||||||||||||||||||:|||:||||||:||
Frog   595 QIAAGMEFLSSHHVVHKDLAARNVLVFDKLSVKISDLGLFREVYAADYYKLMGNSMLPIRWMSPE 659

Human   663 AIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPAWVYALMIE 727
            ||.|||.|:|||||||||:|||:||||||||||||||||:||:||||||.||||||||:|.||:|
Frog   660 AITYGKCSVDSDIWSYGVLLWEIFSYGLQPYCGYSNQDVIEMVRNRQVLLCPDDCPAWIYTLMLE 724

Human   728 CWNEFPSRRPRFKDIHSRLRAWGNLSNYNSSAQTSGASNTTQTSSLSTSPVSNVSNARYVGPKQK 792
            ||:|||:|||||||||:|||.|.|:||||||||||||||||||||||||||||||||||||||.|
Frog   725 CWSEFPARRPRFKDIHTRLRTWENMSNYNSSAQTSGASNTTQTSSLSTSPVSNVSNARYVGPKPK 789

Human   793 APPFPQPQFIPMKGQIRPMVPPPQLYVPVNGYQPVPAYGAYLPNFYPVQIPMQMAPQQVPPQMVP 857
            ..||.||||:||||||||||||||||:||||||.:.||      |||||||||||||.:|||::|
Frog   790 TQPFQQPQFLPMKGQIRPMVPPPQLYIPVNGYQQMAAY------FYPVQIPMQMAPQPMPPQIIP 848

Human   858 KPSSHHSGSGSTSTGYVTTAPSNTSMADRAALLSEGADDTQNAPEDGAQSTVQEAEEEEEGSVPE 922
            ||.||||||||||||||||||||.|||||.|||::|||:.|...||.:.:.||    ||||||||
Frog   849 KPGSHHSGSGSTSTGYVTTAPSNNSMADRVALLADGADEAQLLAEDMSPNPVQ----EEEGSVPE 909

Human   923 TELLGDCDTLQVDEAQVQLEA 943
            ||||||.||..:||..:|.||
Frog   910 TELLGDNDTSHLDETDIQSEA 930

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ROR2	NP_004551.2	I-set	64..152	CDD:254352	78/87 (90%)
		IGc2	75..141	CDD:197706	57/65 (88%)
		CRD_TK_ROR2	170..309	CDD:143577	123/138 (89%)
		KR	314..395	CDD:214527	62/80 (78%)
		PTKc_Ror2	466..749	CDD:270673	234/282 (83%)
		Pkinase_Tyr	473..746	CDD:285015	226/272 (83%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	757..796		35/38 (92%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	850..931		56/80 (70%)
ror2	NP_001015834.1	I-set	62..150	CDD:369462	78/87 (90%)
		CRD_TK_ROR2	168..305	CDD:143577	123/138 (89%)
		KR	310..390	CDD:214527	62/79 (78%)
		PKc_like	463..746	CDD:389743	234/282 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	497	1.000	Domainoid score	I3797
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55831
Inparanoid	1	1.050	1562	1.000	Inparanoid score	I1281
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG48666
OrthoDB	1	1.010	-	-		D222671at33208
OrthoFinder	1	1.000	-	-		FOG0003730
OrthoInspector	1	1.000	-	-		oto149541
Panther	1	1.100	-	-	LDO	PTHR24416
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3136
SonicParanoid	1	1.000	-	-		X2586
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	13.110