DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ROR2 and cam-1

DIOPT Version :9

Sequence 1:	NP_004551.2	Gene:	ROR2 / 4920	HGNCID:	10257	Length:	943	Species:	Homo sapiens
Sequence 2:	NP_001021907.1	Gene:	cam-1 / 174473	WormBaseID:	WBGene00000289	Length:	928	Species:	Caenorhabditis elegans

Alignment Length:	940	Identity:	289/940 - (30%)
Similarity:	418/940 - (44%)	Gaps:	221/940 - (23%)

- Green bases have known domain annotations that are detailed below.

Human    37 VLDPNDPLGPLDGQDGPIPTLKGY--FLNFLEPVNNITIVQGQTAILHCKVAGNPPPNVRWLKND 99
            |::|.|..|...|......|..|.  ::.....:.|.|...|......|:..|.||....||||:
Worm    11 VIEPADDEGLHYGNASMEGTSTGQRPYIRLTSQLRNATKSSGDEVRFKCEALGTPPLKFIWLKNN 75

Human   100 APVVQEPRRIIIRKTEYGSRLRIQDLDTTDTGYYQCVATNGMKTITATGVLFV-----------R 153
            .| |::.:|:.||..|..|||.|..||..|:|||||:.:|...::..|.||.|           :
Worm    76 GP-VEKTKRVKIRDKENSSRLVITQLDVLDSGYYQCIVSNPAASVNTTSVLRVNNVPDAVKLSQK 139

Human   154 LGPTHSPNHNFQDDY-------------HED--------------------------------GF 173
            .|..||..|...|:|             .||                                |.
Worm   140 KGSHHSTKHIAFDEYEDYEMMDRGRLPDEEDADLYRVPDSAAGSNYAPVAVSERWLDGIKYRVGD 204

Human   174 CQPYRGIACARFIGNRTIYV--DSLQMQGEIENRITAAFTMIGTSTHLSDQCSQFAIPSFCHFVF 236
            |..|||.||.:::.|:.:.:  :|.:...:|:..:.||...|..:..:|.:|.|.:....||.::
Worm   205 CVQYRGEACRQYLSNKFVMMTNESREEMYDIDRNLRAAMLFINGAPTISQKCRQLSQAVACHHMY 269

Human   237 PLCDARSRTPKPRELCRDECEVLESDLCRQEYTIARSNPLI--LMRLQLPKCEALPMPESPDAAN 299
            .:|::.|.. :...:|:.:|:|:::|.|..|..:|..:.|:  ..:...|.|..|     ...:|
Worm   270 KVCESDSNN-QIVSICKHDCDVIQNDECPSELALAAQHELVGDTPKALFPLCSRL-----SSTSN 328

Human   300 CMRI------GIPAERLGR---YHQCYNGSGMDYRGTASTTKSGHQCQPWALQHPHSHHLSSTD- 354
            |:.:      ..|...:.|   .|.||..||..|.||.:.|.||.||.||         :.||.
Worm   329 CIPVMSTALQSSPVAEVNRGHLTHWCYVNSGTQYEGTVAQTSSGKQCAPW---------IDSTSR 384

Human   355 ------FPELGGGHAYCRNPGGQMEGPWCFTQNKNVRMELCDVPSCSPRD------------SSK 401
                  ||||.....|||||||:...|||:::... :.|.||||.| |.|            |:|
Worm   385 DFNVHRFPELMNSKNYCRNPGGKKSRPWCYSKPMG-QEEYCDVPQC-PSDMYPHLNDKKVEGSTK 447

Human   402 MGI------LY-ILVPSIAIPLV---------IACLFFLVCMCRNKQKASASTPQRRQLMASPS- 449
            .|:      |: .|.|::.:.||         :..||...|.||.|:|:..:..|.....::||
Worm   448 GGVSESVTALWDSLDPTMQVALVGGGVFFSLLLLLLFCCACCCRAKKKSQKTRHQNAHCSSAPSV 512

Human   450 -------------------------QDMEMPLI--------------NQHKQA------------ 463
                                     ..:||..:              :||.|.
Worm   513 INSAANSAYYRKLNGTSTPIMGRVPPHVEMTSLLPSAQHLGPPPYPMDQHLQQARRFPSQEPIDD 577

Human   464 ---KLKEISLSAVRFMEELGEDRFGKVYKG----HLFGPAPGEQTQAVAIKTLKDKAEGPLREEF 521
               |:.||:.|.:...|::||.:||.|:.|    .||.|.|    .|||:|..:..|....|.:.
Worm   578 NSYKVFEITPSQLSVREKIGEGQFGVVHSGIYTSGLFAPEP----MAVAVKKCRHDATNAERAQL 638

Human   522 RHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSP---HSDVGSTDDDRTV 583
            ..|....|...||||:.|:||...|..|..:|.|..||||||.|.:|.|   |...|.|:.:
Worm   639 EQEIRAVATFDHPNVIKLIGVCYMDNSLLAVFEYMVHGDLHELLKVRVPPADHDMGGITEAN--- 700

Human   584 KSALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKL 648
                  .:|:::..|||.|||||:|...||:||||||.||.|...:||:|.||.|..|.:||||:
Worm   701 ------AEFLYIATQIALGMEYLASMSFVHRDLATRNCLVGDTRTIKIADFGLMRTSYGSDYYKM 759

Human   649 LGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPC 713
            |..|.:|:|||:.|||..|:||..||:||:||.|||::|:|.|||.|.|||.|:|::.||.:|.|
Worm   760 LHRSWMPVRWMSKEAIEQGRFSEASDVWSFGVTLWEIWSFGRQPYEGASNQQVIELVANRHLLEC 824

Human   714 PDDCPAWVYALMIECWNEFPSRRPRFKDIHSRLRAW-------------GNLSNYNSSAQTSGAS 765
            |.:||..:|:||:|||:|...|||.|.:|.|||::|             .|.:..:|.:..:|..
Worm   825 PHNCPTNIYSLMVECWHENIERRPTFSEIRSRLQSWSLASPAHSILQQHNNRAGSHSGSSGAGRP 889

Human   766 NTTQTSSLS---------TSPVSNVSNARY 786
            .|.|....|         .||:....:|.|
Worm   890 PTHQRGYPSQKLHRRVEGASPLMKRHDANY 919

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ROR2	NP_004551.2	I-set	64..152	CDD:254352	33/87 (38%)
		IGc2	75..141	CDD:197706	28/65 (43%)
		CRD_TK_ROR2	170..309	CDD:143577	36/180 (20%)
		KR	314..395	CDD:214527	36/87 (41%)
		PTKc_Ror2	466..749	CDD:270673	131/289 (45%)
		Pkinase_Tyr	473..746	CDD:285015	126/279 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	757..796		9/39 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	850..931
cam-1	NP_001021907.1	I-set	39..127	CDD:254352	33/88 (38%)
		Ig	55..122	CDD:143165	27/67 (40%)
		CRD_TK_ROR_like	203..335	CDD:143568	33/137 (24%)
		KR	352..431	CDD:214527	37/89 (42%)
		STYKc	590..857	CDD:214568	126/279 (45%)
		PTKc	594..858	CDD:270623	127/276 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	247	1.000	Domainoid score	I1322
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55831
Inparanoid	1	1.050	404	1.000	Inparanoid score	I1213
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48666
OrthoDB	1	1.010	-	-		D222671at33208
OrthoFinder	1	1.000	-	-		FOG0003730
OrthoInspector	1	1.000	-	-		otm15557
orthoMCL	1	0.900	-	-		OOG6_105406
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3136
SonicParanoid	1	1.000	-	-		X2586
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.910