Protein Alignment ATP2B3 and PMCA

DIOPT Version :9

• Sequence 1: XP_016885042.1
• Gene: ATP2B3 / 492
• HGNCID: 816
• Length: 1274
• Species: Homo sapiens
• Sequence 2: NP_001014689.3
• Gene: PMCA / 43787
• FlyBaseID: FBgn0259214
• Length: 1255
• Species: Drosophila melanogaster
• Alignment Length: 1128
• Identity: 721/1128 - (63%)
• Similarity: 855/1128 - (75%)
• Gaps: 56/1128 - (4%)

Human    27 FGCTLAELRTLMELRGAEALQKIEEAYGDVSGLCRRLKTSPTEGLADNTNDLEKRRQIYGQNFIP 91
            :|.:|.:||.|||.||.|.:.||.| .|.:..||::|.|||.|||:.:..|.|.||:.:|.|.||
  Fly    11 YGISLKQLRELMEHRGREGVMKIAE-NGGIHELCKKLYTSPNEGLSGSKADEEHRRETFGSNVIP 74

Human    92 PKQPKTFLQLVWEALQDVTLIILEVAAIVSLGLSFYAPPGEESEACGNVSGGAEDEGEAEAGWIE 156
            ||.|||||.||||||||||||||||||:||||||||.|..|::...        .|.|...||||
  Fly    75 PKPPKTFLTLVWEALQDVTLIILEVAALVSLGLSFYKPADEDAPVL--------QEEEEHHGWIE 131

Human   157 GAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVIRNGQLLQVPVAALVVGDIAQVKY 221
            |.|||:|||.||:||||||:|||:||||||:|||.|.||:|||.|::.|:.|..::|||||||||
  Fly   132 GLAILISVIVVVIVTAFNDYSKERQFRGLQNRIEGEHKFSVIRGGEVCQISVGDILVGDIAQVKY 196

Human   222 GDLLPADGVLIQANDLKIDESSLTGESDHVRKSADKDPMLLSGTHVMEGSGRMVVTAVGVNSQTG 286
            ||||||||.|||:||||:||||||||||||:|..|.|||:|||||||||||:|||||||||||.|
  Fly   197 GDLLPADGCLIQSNDLKVDESSLTGESDHVKKGPDVDPMVLSGTHVMEGSGKMVVTAVGVNSQAG 261

Human   287 IIFTLLGAGGEEEEKKDKKGKQQ--------------DGAMESSQTKGTDLGHGVPLCAAKKQDG 337
            ||||||||..:|:|.:.||.|::              ||   .||.||:.         |..|..
  Fly   262 IIFTLLGAAVDEQEAEIKKMKKEAKRANKQKNLTGENDG---RSQIKGSQ---------APSQRE 314

Human   338 AVAMEMQPLKSAEGGEMEEREKKKA--NAPKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVL 400
            .|..|:...:| ||..:.:.....|  ...||||||||.||||||:|||.||..::.:|||||::
  Fly   315 TVTSEITKSES-EGNHLPQSSSSGAAETGHKKEKSVLQAKLTKLAIQIGYAGSTIAVLTVIILII 378

Human   401 YFVIETFVVEGRTWLAECTPVYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNN 465
            .|.|:|||::.:.|    ...|....||..||||||||||||||||||||:||||||||||||||
  Fly   379 QFCIKTFVIDEKPW----KNTYANNLVKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNN 439

Human   466 LVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYLGDTHYKEIPAPSALTPKILDLLVHAISI 530
            ||||||||||||||||||||||||||||||||||||:.:...|.:|..|.:...:.:|:...||:
  Fly   440 LVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYICEKLCKVLPTLSDIPQHVGNLITMGISV 504

Human   531 NSAYTTKILPPEKEGALPRQVGNKTECALLGFVLDLKRDFQPVREQIPEDKLYKVYTFNSVRKSM 595
            |||||:.|:.....|.||.||||||||||||||..|...:|.:|::|.|||..:|||||||||||
  Fly   505 NSAYTSNIMAGHNPGDLPIQVGNKTECALLGFVQGLGVKYQSIRDEITEDKFTRVYTFNSVRKSM 569

Human   596 STVIRMPDGGFRLFSKGASEILLKKCTNILNSNGELRGFRPRDRDDMVRKIIEPMACDGLRTICI 660
            .|||..|:||:||::||||||::|||..|....|.|..|....::.::|::||||||||||||.:
  Fly   570 GTVIPRPNGGYRLYTKGASEIIMKKCAFIYGHEGTLEKFTRDMQERLIREVIEPMACDGLRTISV 634

Human   661 AYRDFSAGQ----------EPDWDNENEVVGDLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRM 715
            |||||..|:          ||:||:|..::.:|||:.|||||||||||||:||||||||||||||
  Fly   635 AYRDFVPGKAAINEVHIDGEPNWDDEENIMTNLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVRM 699

Human   716 VTGDNINTARAIAAKCGIIQPGEDFLCLEGKEFNRRIRNEKGEIEQERLDKVWPKLRVLARSSPT 780
            ||||||||||:||:||||::|.:|||.|||||||||||:..|:|:|..:||||||||||||||||
  Fly   700 VTGDNINTARSIASKCGILRPNDDFLILEGKEFNRRIRDSNGDIQQHLIDKVWPKLRVLARSSPT 764

Human   781 DKHTLVKGIIDSTTGEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFT 845
            ||:||||||||||..|.|:|||||||||||||||||||||||||||||||||||||||||||||:
  Fly   765 DKYTLVKGIIDSTVSENREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFS 829

Human   846 SIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLA 910
            ||||||||||||||||:||||||||||||||||||.|||..|||||||||||||||||||.||||
  Fly   830 SIVKAVMWGRNVYDSIAKFLQFQLTVNVVAVIVAFIGACAVQDSPLKAVQMLWVNLIMDTLASLA 894

Human   911 LATEPPTESLLLRKPYGRDKPLISRTMMKNILGHAVYQLAIIFTLLFVGELFFDIDSGRNAPLHS 975
            ||||.||..|||||||||.||||||||||||||.|:|||.|||.|||||::..||:|||...|::
  Fly   895 LATEFPTPDLLLRKPYGRTKPLISRTMMKNILGQALYQLIIIFGLLFVGDVILDIESGRGQELNA 959

Human   976 PPSEHYTIIFNTFVMMQLFNEINARKIHGERNVFDGIFSNPIFCTIVLGTFGIQIVIVQFGGKPF 1040
            .|::|:||||||||||.||||||||||||:|||.:|:.:||||.||.:.|...|::|:|:|...|
  Fly   960 GPTQHFTIIFNTFVMMTLFNEINARKIHGQRNVIEGLLTNPIFYTIWIFTMISQVLIIQYGKMAF 1024

Human  1041 SCSPLSTEQWLWCLFVGVGELVWGQVIATIPTSQLKCLKEAGHGPGKDEMTDEELAEGEEEID-- 1103
            |...|:.:|||||:|.|:|.|||||:|.::||.:|..:...|.| ..:|.|| .:..|||..|
  Fly  1025 STKALTLDQWLWCIFFGIGTLVWGQLITSVPTRKLPKILSWGRG-HPEEYTD-GMNLGEERFDSI 1087

Human  1104 HAERELRRGQILWFRGLNRIQTQ 1126
            .::::.|.|||||.|||.|:|||
  Fly  1088 DSDKKPRAGQILWIRGLTRLQTQ 1110

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP2B3	XP_016885042.1	None
PMCA	NP_001014689.3	ATPase-IIB_Ca	1..1057	CDD:273668	697/1071 (65%)
		Cation_ATPase_N	36..104	CDD:279080	43/67 (64%)
		E1-E2_ATPase	172..448	CDD:278548	171/292 (59%)
		Cation_ATPase	505..598	CDD:289987	58/92 (63%)
		HAD_like	676..807	CDD:119389	109/130 (84%)
		Cation_ATPase_C	873..1051	CDD:279079	123/177 (69%)
		ATP_Ca_trans_C	1096..1142	CDD:289209	12/15 (80%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I2040
eggNOG	1	0.900	-	-		E2759_KOG0204
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H123775
Inparanoid	1	1.050	1374	1.000	Inparanoid score	I126
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D115892at2759
OrthoFinder	1	1.000	-	-		FOG0000362
OrthoInspector	1	1.000	-	-		otm40424
orthoMCL	1	0.900	-	-		OOG6_100143
Panther	1	1.100	-	-	LDO	PTHR24093
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R99
SonicParanoid	1	1.000	-	-		X220
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.870