DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)37Cc and STOML1

DIOPT Version :9

Sequence 1:	NP_001163012.2	Gene:	l(2)37Cc / 49168	FlyBaseID:	FBgn0002031	Length:	276	Species:	Drosophila melanogaster
Sequence 2:	NP_004800.2	Gene:	STOML1 / 9399	HGNCID:	14560	Length:	398	Species:	Homo sapiens

Alignment Length:	177	Identity:	35/177 - (19%)
Similarity:	73/177 - (41%)	Gaps:	20/177 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 GEGTHFFIPWVQRPIIFDIRSQPRNVPVI-TGSKDLQNVNITLRILYRPIPDQLPKIYTILGQDY 114
            |.|....:|::......|:|::..|||.. ..|||...:::...:.:| |.|.:..:.|:  :|.
Human   101 GPGMVLLLPFIDSFQRVDLRTRAFNVPPCKLASKDGAVLSVGADVQFR-IWDPVLSVMTV--KDL 162

  Fly   115 DERVLPSIAPEVLKAVVAQFDAGELITQREMVSQRVSQELTVRAKQFGFILDDISLTHLTFGREF 179
            :.....:....:.||::.: ...|:..::..:|.::..|:....:.:|..:|.:.
Human   163 NTATRMTAQNAMTKALLKR-PLREIQMEKLKISDQLLLEINDVTRAWGLEVDRVE---------- 216

  Fly   180 TLAVEMKQVAQQEAEKARFVVEKAEQQKL----ASIISAEGDAEAAG 222
             ||||......|::.....:....:|..|    .|:.|..|.|.:.|
Human   217 -LAVEAVLQPPQDSPAGPNLDSTLQQLALHFLGGSMNSMAGGAPSPG 262

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cc	NP_001163012.2	SPFH_prohibitin	27..221	CDD:259799	34/174 (20%)
STOML1	NP_004800.2	Tyrosine-type lysosomal sorting signal. /evidence=ECO:0000255, ECO:0000269\|PubMed:19696025	6..10
		PHB	77..217	CDD:214581	23/130 (18%)
		SPFH_SLP-1	94..224	CDD:259814	27/137 (20%)
		SCP2	304..395	CDD:280250
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0330
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810