DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)37Cc and PHB1

DIOPT Version :9

Sequence 1:	NP_001163012.2	Gene:	l(2)37Cc / 49168	FlyBaseID:	FBgn0002031	Length:	276	Species:	Drosophila melanogaster
Sequence 2:	NP_011648.3	Gene:	PHB1 / 853033	SGDID:	S000003364	Length:	287	Species:	Saccharomyces cerevisiae

Alignment Length:	264	Identity:	144/264 - (54%)
Similarity:	207/264 - (78%)	Gaps:	0/264 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 AAQFFNRIGQMGLGVAVLGGVVNSALYNVEGGHRAVIFDRFTGIKENVVGEGTHFFIPWVQRPII 66
            :|:..:.|.::.|.:.::...:..::|:|:||.|.|||||..|:|:.||||||||.:||:|:.||
Yeast     4 SAKLIDVITKVALPIGIIASGIQYSMYDVKGGSRGVIFDRINGVKQQVVGEGTHFLVPWLQKAII 68

  Fly    67 FDIRSQPRNVPVITGSKDLQNVNITLRILYRPIPDQLPKIYTILGQDYDERVLPSIAPEVLKAVV 131
            :|:|::|:::...||:||||.|::|||:|:||...|||.||..||.||||||||||..||||::|
Yeast    69 YDVRTKPKSIATNTGTKDLQMVSLTLRVLHRPEVLQLPAIYQNLGLDYDERVLPSIGNEVLKSIV 133

  Fly   132 AQFDAGELITQREMVSQRVSQELTVRAKQFGFILDDISLTHLTFGREFTLAVEMKQVAQQEAEKA 196
            |||||.|||||||::||::.:||:.||.:||..|:|:|:||:|||.|||.|||.||:|||:||:|
Yeast   134 AQFDAAELITQREIISQKIRKELSTRANEFGIKLEDVSITHMTFGPEFTKAVEQKQIAQQDAERA 198

  Fly   197 RFVVEKAEQQKLASIISAEGDAEAAGLLAKSFGEAGDGLVELRRIEAAEDIAYQLSRSRGVAYLP 261
            :|:||||||::.||:|.|||:||:|..::|:..:.||||:.:||:||::|||..|:.|..|.|||
Yeast   199 KFLVEKAEQERQASVIRAEGEAESAEFISKALAKVGDGLLLIRRLEASKDIAQTLANSSNVVYLP 263

  Fly   262 SGQS 265
            |..|
Yeast   264 SQHS 267

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cc	NP_001163012.2	SPFH_prohibitin	27..221	CDD:259799	120/193 (62%)
PHB1	NP_011648.3	SPFH_prohibitin	29..223	CDD:259799	120/193 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343647
Domainoid	1	1.000	234	1.000	Domainoid score	I396
eggNOG	1	0.900	-	-		E1_COG0330
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1980
Inparanoid	1	1.050	304	1.000	Inparanoid score	I493
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63567
OrthoFinder	1	1.000	-	-		FOG0003661
OrthoInspector	1	1.000	-	-		oto100216
orthoMCL	1	0.900	-	-		OOG6_101926
Panther	1	1.100	-	-	LDO	PTHR23222
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R920
SonicParanoid	1	1.000	-	-		X2109
TreeFam	1	0.960	-	-
	15	14.790