DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)37Cc and Stoml1

DIOPT Version :9

Sequence 1:	NP_001163012.2	Gene:	l(2)37Cc / 49168	FlyBaseID:	FBgn0002031	Length:	276	Species:	Drosophila melanogaster
Sequence 2:	NP_081218.3	Gene:	Stoml1 / 69106	MGIID:	1916356	Length:	399	Species:	Mus musculus

Alignment Length:	320	Identity:	64/320 - (20%)
Similarity:	109/320 - (34%)	Gaps:	100/320 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 VAVLGGVVNSALYNVEGG---------HRAVIFDRFTGIKENVVGEGTHFFIPWVQRPIIFDIRS 71
            |:|||.::....:.:.|.         .|.::| |...|: |..|.|....:|::......|:|:
Mouse    59 VSVLGFLLLLLTFPISGWFALKIVPTYERMIVF-RLGRIR-NPQGPGMVLLLPFIDSFQRVDLRT 121

  Fly    72 QPRNVPVI-TGSKDLQNVNITLRILYRPIPDQLPKIYTILGQDYDERVLPSIAPEVLKAVVAQFD 135
            :..|||.. ..|||...:::...:.:|                        |...||..:..:
Mouse   122 RAFNVPPCKLASKDGAVLSVGADVQFR------------------------IWDPVLSVMAVK-- 160

  Fly   136 AGELITQREMVSQRVSQELTVRAKQFGFILDDISLTHLTFGREFTLAVEMKQVAQQ---EAEKAR 197
              :|.|...|.:.....:..:|..     |.:|.:..|..|.:  |.:|:..|.:.   |.::..
Mouse   161 --DLNTATRMTAHNAMTKALLRRP-----LQEIQMEKLKIGDQ--LLLEINDVTRAWGLEVDRVE 216

  Fly   198 FVVEKAEQ---------------QKLA------SIISAEG--------------DAEAAGLLAKS 227
            ..||...|               |:||      |:.||.|              :.|....||.:
Mouse   217 LAVEAVLQPPQDSLTVPSLDSTLQQLALHLLGGSMNSAVGHVPSPGPDTLEMINEVEPPASLAGA 281

  Fly   228 FGE------AGDGLVELRRIEAAEDIAYQLSRSRGVAY-----LPSGQSTLLNLPSTIAQ 276
            ..|      ..:||:...:...:|.:..|:    |..|     ||||..::..|..|..|
Mouse   282 GPEPSPKQPVAEGLLTALQPFLSEALVSQV----GACYQFNVILPSGTQSIYFLDLTTGQ 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cc	NP_001163012.2	SPFH_prohibitin	27..221	CDD:259799	44/241 (18%)
Stoml1	NP_081218.3	Tyrosine-type lysosomal sorting signal. /evidence=ECO:0000250\|UniProtKB:Q9UBI4, ECO:0000255	6..10
		PHB	77..217	CDD:214581	32/176 (18%)
		SPFH_SLP-1	94..224	CDD:259814	31/165 (19%)
		SCP2	305..396	CDD:280250	11/37 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0330
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900