DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)37Cc and STOML2

DIOPT Version :9

Sequence 1:	NP_001163012.2	Gene:	l(2)37Cc / 49168	FlyBaseID:	FBgn0002031	Length:	276	Species:	Drosophila melanogaster
Sequence 2:	NP_038470.1	Gene:	STOML2 / 30968	HGNCID:	14559	Length:	356	Species:	Homo sapiens

Alignment Length:	329	Identity:	67/329 - (20%)
Similarity:	120/329 - (36%)	Gaps:	90/329 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 GLGVAVLGGVVNSALYNVEGGHRAVIFDRFTGIKENVVGEGTHFFIP----W-VQRPIIFDIRSQ 72
            |.|..:|.|   |.|.:.....||     .:|:..|.|    ..|:|    | |:|...|....:
Human     8 GTGALLLRG---SLLASGRAPRRA-----SSGLPRNTV----VLFVPQQEAWVVERMGRFHRILE 60

  Fly    73 PR---NVPVITGSKDLQNV----------------NITLRI---LYRPIPDQLPKIYTILGQDYD 115
            |.   .:||:...:.:|::                |:||:|   ||..|.|.....|   |.:..
Human    61 PGLNILIPVLDRIRYVQSLKEIVINVPEQSAVTLDNVTLQIDGVLYLRIMDPYKASY---GVEDP 122

  Fly   116 ERVLPSIAPEVLKAVVAQFDAGELITQREMVSQRVSQELTVRAKQFG-----FILDDISLTHLTF 175
            |..:..:|...:::.:.:....::..:||.::..:...:...|..:|     :.:.||.:..
Human   123 EYAVTQLAQTTMRSELGKLSLDKVFRERESLNASIVDAINQAADCWGIRCLRYEIKDIHVPP--- 184

  Fly   176 GREFTLAVEMKQVAQQEAEKARFVVEK----------AEQQKLASIISAEGD---------AEAA 221
                .:...|:...:.|..|...|:|.          ||.:|.|.|:::|.:         .||:
Human   185 ----RVKESMQMQVEAERRKRATVLESEGTRESAINVAEGKKQAQILASEAEKAEQINQAAGEAS 245

  Fly   222 GLLAKSFGEA--------------GDGLVELRRIEAAEDIAYQLSRSRGVAYLPSGQSTLLNLPS 272
            .:|||:..:|              ||....|...|.......:|::......|||...   ::.|
Human   246 AVLAKAKAKAEAIRILAAALTQHNGDAAASLTVAEQYVSAFSKLAKDSNTILLPSNPG---DVTS 307

  Fly   273 TIAQ 276
            .:||
Human   308 MVAQ 311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cc	NP_001163012.2	SPFH_prohibitin	27..221	CDD:259799	46/244 (19%)
STOML2	NP_038470.1	HflC	41..314	CDD:223407	55/284 (19%)
		SPFH_paraslipin	74..184	CDD:259811	19/112 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	321..356
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0330
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810