DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)37Cc and phb1

DIOPT Version :9

Sequence 1:	NP_001163012.2	Gene:	l(2)37Cc / 49168	FlyBaseID:	FBgn0002031	Length:	276	Species:	Drosophila melanogaster
Sequence 2:	NP_594713.1	Gene:	phb1 / 2542354	PomBaseID:	SPAC1782.06c	Length:	282	Species:	Schizosaccharomyces pombe

Alignment Length:	279	Identity:	143/279 - (51%)
Similarity:	208/279 - (74%)	Gaps:	11/279 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 AQFFNRIGQMGLGVAVLGGVVNSALYNVEGGHRAVIFDRFTGIKENVVGEGTHFFIPWVQRPIIF 67
            |....|:.:..:.:.:...::.|::|:|.||.|||:|||.:|:::.||.|||||.|||:|:.|::
pombe     2 AVVLERVARYAIPIGIGFTLLQSSIYDVPGGKRAVLFDRLSGVQKQVVQEGTHFLIPWLQKAIVY 66

  Fly    68 DIRSQPRNVPVITGSKDLQNVNITLRILYRPIPDQLPKIYTILGQDYDERVLPSIAPEVLKAVVA 132
            |:|::|||:...|||||||.|::|||:|:||....||:||..||.||||||||||..|:||:|||
pombe    67 DVRTRPRNIATTTGSKDLQMVSLTLRVLHRPEVGMLPQIYQNLGLDYDERVLPSIGNEILKSVVA 131

  Fly   133 QFDAGELITQREMVSQRVSQELTVRAKQFGFILDDISLTHLTFGREFTLAVEMKQVAQQEAEKAR 197
            ||||.|||||||:||.::.|||..||.:||..|:|:|:||:|||:|||.|||.||:||||||:||
pombe   132 QFDAAELITQREVVSAKIRQELVQRATEFGIRLEDVSITHMTFGKEFTKAVERKQIAQQEAERAR 196

  Fly   198 FVVEKAEQQKLASIISAEGDAEAAGLLAKSFGEAGDGLVELRRIEAAEDIAYQL-SRSRGVAYLP 261
            |:||::||::.|::|.|||:||||.:::|:..:||..|:::||:|.::::|..| ::...|.|||
pombe   197 FLVEQSEQERQANVIRAEGEAEAADIVSKALDKAGGALIQIRRLETSKEVATALANKGAQVTYLP 261

  Fly   262 ----------SGQSTLLNL 270
                      ||...|||:
pombe   262 FGAGSNAQSSSGSGLLLNV 280

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cc	NP_001163012.2	SPFH_prohibitin	27..221	CDD:259799	120/193 (62%)
phb1	NP_594713.1	PHB	24..186	CDD:214581	99/161 (61%)
phb1	NP_594713.1	SPFH_prohibitin	26..220	CDD:259799	120/193 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	234	1.000	Domainoid score	I487
eggNOG	1	0.900	-	-		E1_COG0330
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1980
Inparanoid	1	1.050	290	1.000	Inparanoid score	I635
OMA	1	1.010	-	-		QHG63567
OrthoFinder	1	1.000	-	-		FOG0003661
OrthoInspector	1	1.000	-	-		oto101972
orthoMCL	1	0.900	-	-		OOG6_101926
Panther	1	1.100	-	-	LDO	PTHR23222
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R920
SonicParanoid	1	1.000	-	-		X2109
TreeFam	1	0.960	-	-
	14	13.860