Protein Alignment Phb1 and Phb2

DIOPT Version :10

• Sequence 1: NP_476607.2
• Gene: Phb1 / 49168
• FlyBaseID: FBgn0002031
• Length: 276
• Species: Drosophila melanogaster
• Sequence 2: NP_001013053.1
• Gene: Phb2 / 114766
• RGDID: 620203
• Length: 299
• Species: Rattus norvegicus
• Alignment Length: 270
• Identity: 135/270 - (50%)
• Similarity: 193/270 - (71%)
• Gaps: 11/270 - (4%)

  Fly    10 GQMGLGVAV-----LGGV---VNSALYNVEGGHRAVIFDRFTGIKEN-VVGEGTHFFIPWVQRPI 65
            |..|:|.|:     .|.|   |..:::.|||||||:.|:|..|:::: ::.||.||.|||.|.||
  Rat    15 GPRGMGTALKLLLGAGAVAYGVRESVFTVEGGHRAIFFNRIGGVQQDTILAEGLHFRIPWFQYPI 79

  Fly    66 IFDIRSQPRNVPVITGSKDLQNVNITLRILYRPIPDQLPKIYTILGQDYDERVLPSIAPEVLKAV 130
            |:|||::||.:...|||||||.|||:||:|.||...:||.:|..||.||:|||||||..||||:|
  Rat    80 IYDIRARPRKISSPTGSKDLQMVNISLRVLSRPNAQELPSMYQRLGLDYEERVLPSIVNEVLKSV 144

  Fly   131 VAQFDAGELITQREMVSQRVSQELTVRAKQFGFILDDISLTHLTFGREFTLAVEMKQVAQQEAEK 195
            ||:|:|.:|||||..||..:.:|||.|||.|..||||:::|.|:|.||:|.|||.||||||||::
  Rat   145 VAKFNASQLITQRAQVSLLIRRELTERAKDFSLILDDVAITELSFSREYTAAVEAKQVAQQEAQR 209

  Fly   196 ARFVVEKAEQQKLASIISAEGDAEAAGLLAKSFGEAGDGLVELRRIEAAEDIAYQLSRSRGVAYL 260
            |:|:||||:|::...|:.|||:||||.:|.::..: ..|.::||:|.||::|:..::.|:...||
  Rat   210 AQFLVEKAKQEQRQKIVQAEGEAEAAKMLGEALSK-NPGYIKLRKIRAAQNISKTIATSQNRIYL 273

  Fly   261 PSGQSTLLNL 270
             :..:.:|||
  Rat   274 -TADNLVLNL 282

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Phb1	NP_476607.2	SPFH_prohibitin	27..221	CDD:259799	112/194 (58%)
Phb2	NP_001013053.1	Necessary for transcriptional repression. /evidence=ECO:0000250|UniProtKB:Q99623	19..49		10/29 (34%)
		SPFH_prohibitin	40..235	CDD:259799	112/194 (58%)
		Necessary for transcriptional repression. /evidence=ECO:0000250|UniProtKB:Q99623	150..174		13/23 (57%)