Protein Alignment Phb1 and PHB2

DIOPT Version :10

• Sequence 1: NP_476607.2
• Gene: Phb1 / 49168
• FlyBaseID: FBgn0002031
• Length: 276
• Species: Drosophila melanogaster
• Sequence 2: NP_001138303.1
• Gene: PHB2 / 11331
• HGNCID: 30306
• Length: 299
• Species: Homo sapiens
• Alignment Length: 270
• Identity: 135/270 - (50%)
• Similarity: 193/270 - (71%)
• Gaps: 11/270 - (4%)

  Fly    10 GQMGLGVAV-----LGGV---VNSALYNVEGGHRAVIFDRFTGIKEN-VVGEGTHFFIPWVQRPI 65
            |..|:|.|:     .|.|   |..:::.|||||||:.|:|..|:::: ::.||.||.|||.|.||
Human    15 GPRGMGTALKLLLGAGAVAYGVRESVFTVEGGHRAIFFNRIGGVQQDTILAEGLHFRIPWFQYPI 79

  Fly    66 IFDIRSQPRNVPVITGSKDLQNVNITLRILYRPIPDQLPKIYTILGQDYDERVLPSIAPEVLKAV 130
            |:|||::||.:...|||||||.|||:||:|.||...:||.:|..||.||:|||||||..||||:|
Human    80 IYDIRARPRKISSPTGSKDLQMVNISLRVLSRPNAQELPSMYQRLGLDYEERVLPSIVNEVLKSV 144

  Fly   131 VAQFDAGELITQREMVSQRVSQELTVRAKQFGFILDDISLTHLTFGREFTLAVEMKQVAQQEAEK 195
            ||:|:|.:|||||..||..:.:|||.|||.|..||||:::|.|:|.||:|.|||.||||||||::
Human   145 VAKFNASQLITQRAQVSLLIRRELTERAKDFSLILDDVAITELSFSREYTAAVEAKQVAQQEAQR 209

  Fly   196 ARFVVEKAEQQKLASIISAEGDAEAAGLLAKSFGEAGDGLVELRRIEAAEDIAYQLSRSRGVAYL 260
            |:|:||||:|::...|:.|||:||||.:|.::..: ..|.::||:|.||::|:..::.|:...||
Human   210 AQFLVEKAKQEQRQKIVQAEGEAEAAKMLGEALSK-NPGYIKLRKIRAAQNISKTIATSQNRIYL 273

  Fly   261 PSGQSTLLNL 270
             :..:.:|||
Human   274 -TADNLVLNL 282

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Phb1	NP_476607.2	SPFH_prohibitin	27..221	CDD:259799	112/194 (58%)
PHB2	NP_001138303.1	Necessary for transcriptional repression. /evidence=ECO:0000269|PubMed:10359819	19..49		10/29 (34%)
		SPFH_prohibitin	40..235	CDD:259799	112/194 (58%)
		LC3-interaction region. /evidence=ECO:0000269|PubMed:28017329	121..124		1/2 (50%)
		Necessary for transcriptional repression. /evidence=ECO:0000269|PubMed:10359819	150..174		13/23 (57%)