DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp303a1 and Cyp2c23

DIOPT Version :9

Sequence 1:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_114027.2	Gene:	Cyp2c23 / 83790	RGDID:	620370	Length:	494	Species:	Rattus norvegicus

Alignment Length:	511	Identity:	138/511 - (27%)
Similarity:	254/511 - (49%)	Gaps:	42/511 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VIWIFCATLLAILFGGVRKPKRFPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQYVNPYG 69
            |:.:.|.:||:: :..:|...|.||||...||:|:.||::         .|.|.....:....||
  Rat    12 VVSVTCLSLLSV-WTKLRTRGRLPPGPTPLPIIGNLLQLN---------LKDIPASLSKLAKEYG 66

  Fly    70 -FYGLKIGKDKVVIAYTNDAISEMMTNEDIDGRPDGIFYRLRTFNSRLGVLLTDGEMWVEQRRFI 133
             .|.|..|....|:.:..|.:.|.:..:..:....|....:...:...|::.::||.|...|||.
  Rat    67 PVYTLYFGTSPTVVLHGYDVVKEALLQQGDEFLGRGPLPIIEDTHKGYGLIFSNGERWKVMRRFS 131

  Fly   134 LRHLKNFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVYV---LNTLWCMLS 195
            |..|:|||..:..:.:.|..||.||:::|         ::|:.:..|.|.:..   .|.:..:|.
  Rat   132 LMTLRNFGMGKRSLEERVQEEARCLVEEL---------QKTKAQPFDPTFILACAPCNVICSILF 187

  Fly   196 GRRYEPGSPEITQLLETFFELFKNIDMVGA-LFSHFPLLRFIAPNFSGYNGFVESHRSLYTFMSK 259
            ..|::..:.....|::...:.|:.::.|.. :::.:|.:....|  ..:..|.:....:..|:.:
  Rat   188 NDRFQYNNKTFLNLMDLLNKNFQQVNSVWCQMYNLWPTIIKYLP--GKHIEFAKRIDDVKNFILE 250

  Fly   260 EIELHRLTYKNYD--EPRDLMDSYL-RAQDEGNDEKGMFSDQSLLAIC-LDMFLAGSETTNKSLG 320
            :::.|:   |:.|  .|||.:|.:| :.::|.::.|..|..:: ||:| .::|.||:|||:.:|.
  Rat   251 KVKEHQ---KSLDPANPRDYIDCFLSKIEEEKDNLKSEFHLEN-LAVCGSNLFTAGTETTSTTLR 311

  Fly   321 FCFMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFMLHTFGIPHRAV 385
            |..:.|:..||:|.:..:|:..|:|..:.|. .:|:.||||.:|:..|..|...|....:||..|
  Rat   312 FGLLLLMKYPEVQAKVHEELDRVIGRHQPPS-MKDKMKLPYTDAVLHEIQRYITLLPSSLPHAVV 375

  Fly   386 CDTRLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYL-FDGHLKLPEAFNPFGFGRHRCM 449
            .||:...|.|||.|.|:.....::::..:|.:||.|:|..:| .:|..|..:.|.||..|:..|:
  Rat   376 QDTKFRDYVIPKGTTVLPMLSSVMLDQKEFANPEKFDPGHFLDKNGCFKKTDYFVPFSLGKRACV 440

  Fly   450 GDLLGRQNLFMFTTTVLQNFKMVAIPGQVPEEVPLEGATAAV----KPYDIMLVAR 501
            |:.|.|..||:|.||:||.|.:..:  ..|:::.::..|..:    .||.:.||.|
  Rat   441 GESLARMELFLFFTTLLQKFSLKTL--VEPKDLDIKPITTGIINLPPPYKLCLVPR 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	125/461 (27%)
Cyp2c23	NP_114027.2	p450	34..491	CDD:278495	129/483 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920