DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp303a1 and CYP81D8

DIOPT Version :9

Sequence 1:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_195453.1	Gene:	CYP81D8 / 829891	AraportID:	AT4G37370	Length:	497	Species:	Arabidopsis thaliana

Alignment Length:	541	Identity:	122/541 - (22%)
Similarity:	234/541 - (43%)	Gaps:	102/541 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TVIW--IFCATLLAILFGGVRKPKRFPPGPAW-YPIVG--SALQVSQLRCRLGMFCKVIDVFARQ 63
            |:|:  :|....|..|.|.:::....||.||| .|::|  ..|:....|..|.:         .|
plant     5 TLIFSILFVVLSLIYLIGKLKRKPNLPPSPAWSLPVIGHLRLLKPPIHRTFLSL---------SQ 60

  Fly    64 YVNPYGFYGLKIGKDKVVIAYTNDAISEMMTNEDI--DGRPDGIFYRLRTFNSRLGVLLTDGEMW 126
            .:|....:.|::|...|.:..::....|..|..|:  ..||:.|..:...::....:..:.|:.|
plant    61 SLNNAPIFSLRLGNRLVFVNSSHSIAEECFTKNDVVLANRPNFILAKHVAYDYTTMIAASYGDHW 125

  Fly   127 VEQRRFILRHLKNFGFARSGMMDIVHN-EATCLLQDLKDKVLKSGGKQTR--------IEMHDLT 182
                    |:|:     |.|.::|..| .....|...||::.:...:.:|        ::|..:.
plant   126 --------RNLR-----RIGSVEIFSNHRLNSFLSIRKDEIRRLVFRLSRNFSQEFVKVDMKSML 177

  Fly   183 SVYVLNTLWCMLSGRRY-------EPGSPEITQLLETFFELFKNIDMV-----GALFSHFPLLRF 235
            |....|.:..|::|:||       :|.:..:.||:         .|:|     |....:.|:||.
plant   178 SDLTFNNILRMVAGKRYYGDGVEDDPEAKRVRQLI---------ADVVACAGAGNAVDYLPVLRL 233

  Fly   236 IAPNFSGYNGFVESHRSLYTFMSKEIELHRLTYKNYDEPRDLMDSYLRAQDEGN----------- 289
            :    |.|                |..:.:|..:..:..:.|:|....|:::||
plant   234 V----SDY----------------ETRVKKLAGRLDEFLQGLVDEKREAKEKGNTMIDHLLTLQE 278

  Fly   290 DEKGMFSDQSLLAICLDMFLAGSETTNKSLGFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWSR 354
            .:...|:|:.:....|.:.|||::|:..:|.:...:::..|::..:|..||...:||:|:.:.|
plant   279 SQPDYFTDRIIKGNMLALILAGTDTSAVTLEWALSNVLNHPDVLNKARDEIDRKIGLDRLMDES- 342

  Fly   355 DRTKLPYCEAITLEAVRMFMLHTFGIPHRAVCDTRLSGYEIPKDTMVIACFRGMLINPVDFPDPE 419
            |.:.|||.:.|..|.:|::......:||.|..|.:::||::|:.|:::.....:..:|..:.||.
plant   343 DISNLPYLQNIVSETLRLYPAAPMLLPHVASEDCKVAGYDMPRGTILLTNVWAIHRDPQLWDDPM 407

  Fly   420 SFNPDRYLFDGHLKLPEAFNPFGFGRHRCMGDLLGRQNLFMFTTTVLQNFKMVAIPGQVPEEVPL 484
            ||.|:|:..:|.   .:...|||.||..|.|..|..:.:.:...:::|..:.    .::.|||.:
plant   408 SFKPERFEKEGE---AQKLMPFGLGRRACPGSGLAHRLINLTLGSLIQCLEW----EKIGEEVDM 465

  Fly   485 ---EGAT-AAVKPYDIMLVAR 501
               :|.| ...||.:.|..||
plant   466 SEGKGVTMPKAKPLEAMCRAR 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	106/488 (22%)
CYP81D8	NP_195453.1	p450	5..487	CDD:299894	122/541 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.000