DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp303a1 and cyp2aa9

DIOPT Version :9

Sequence 1:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_001073320.1	Gene:	cyp2aa9 / 790957	ZFINID:	ZDB-GENE-080724-3	Length:	499	Species:	Danio rerio

Alignment Length:	476	Identity:	128/476 - (26%)
Similarity:	231/476 - (48%)	Gaps:	39/476 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RFPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQYVNPYGFYG----LKIGKDKVVIAYTN 86
            ||||||...|.||:...:.:.              ..:::.....||    :.:|:...::..|.
Zfish    38 RFPPGPTPLPFVGNLPHLLKK--------------PMEFIRSLSQYGEMTTMYLGRKPAIVLNTY 88

  Fly    87 DAISEMMTNEDIDGRPDGIFYRLRTFNSRLG-VLLTDGEMWVEQRRFILRHLKNFGFARSGMMDI 150
            ....|.:..|...|||.  ...:......|| |::|....|.:||||....|:|||..:..:...
Zfish    89 QVAKEALVQEAFAGRPH--LPIIEWITKGLGIVMVTFNNSWKQQRRFAQHTLRNFGLGKKSLESR 151

  Fly   151 VHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVYVLNTLWCMLSGRRYEPGSPEITQLLETFFE 215
            |..|:..|:.::    ||..|:... ..|.:.:. :.|.:..::.|.|::..:.....||:...|
Zfish   152 VLEESQYLIAEM----LKDEGRPMN-PQHAVQNA-LSNIICSIVFGDRFDYNNKRFEYLLKILNE 210

  Fly   216 -LFKNIDMVGALFSHFPLLRFIAPNFSGYNGFV-ESHRSLYTFMSKEIELHRLTYKNYDEPRDLM 278
             :.......|.:|:..|:::    :|.|.:..: |:...:|:|:..|:|.||.|. :...|||.:
Zfish   211 SIILTGSAAGQIFNFAPIIK----HFPGPHQMINENANEVYSFVRHEVEEHRKTL-DPGSPRDFI 270

  Fly   279 DSY-LRAQDEGNDEKGMFSDQSLLAICLDMFLAGSETTNKSLGFCFMHLVLQPEIQERAFQEIKE 342
            |.| |..:.:.:::...|.:.:|:...:|:|||||::|:.|:.:..:.|:..|::|||..:||.:
Zfish   271 DGYLLEIEKQKSNKDSTFHEDNLITTTVDLFLAGSDSTSSSIRWGLLFLIQNPDVQERCHEEIVQ 335

  Fly   343 VVGLERIPEWSRDRTKLPYCEAITLEAVRMFMLHTFGIPHRAVCDTRLSGYEIPKDTMVIACFRG 407
            |:|.:|:| ...||.:|||..|...|..|...:..||:.|.....|:|.||.||:.|:::..:..
Zfish   336 VLGYDRLP-CMDDRDRLPYTLATVHEIQRCGNIAPFGLFHETAQPTKLRGYNIPQGTIIMTNYTA 399

  Fly   408 MLINPVDFPDPESFNPDRYLFD-GHLKLPEAFNPFGFGRHRCMGDLLGRQNLFMFTTTVLQNFKM 471
            :..|...:..|::|||:.:|.: ||...|:.|..||.|...|:||.|.:..||:|.|::||..:.
Zfish   400 IFSNKEHWKHPDTFNPENFLDENGHFSKPKCFIAFGVGPRICLGDTLAKTALFLFITSLLQRIRF 464

  Fly   472 VAIPGQVPEEVPLEGATAAVK 492
            ...|...|  :.::|..:.::
Zfish   465 SLPPDAKP--MDMDGILSIIR 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	124/460 (27%)
cyp2aa9	NP_001073320.1	RSN1_TM	10..>63	CDD:290675	9/38 (24%)
cyp2aa9	NP_001073320.1	p450	40..488	CDD:278495	126/474 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.820