DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp303a1 and cyp2x9

DIOPT Version :9

Sequence 1:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_001070921.1	Gene:	cyp2x9 / 768288	ZFINID:	ZDB-GENE-061027-109	Length:	491	Species:	Danio rerio

Alignment Length:	513	Identity:	159/513 - (30%)
Similarity:	245/513 - (47%)	Gaps:	41/513 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 FYTVIWIFCATLLAILFGGVRKPKRFPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQYVN 66
            |..::|| |..|| .||..:.:||.|||||...|:.|:.|:::     :....|..:..|.:|.|
Zfish     4 FLILVWI-CIVLL-FLFIQIPRPKNFPPGPRPLPLFGNLLELN-----INNPLKDFERLANRYGN 61

  Fly    67 PYGFYGLKIGKDKVVIAYTNDAISEMMTNEDID--GRPDGIFYRLRTFNSRLGVLLTD-GEMWVE 128
            .|..|   .|....|:....:|:.|.:..:.:|  |||..:.....|...  ||:|:| |..|.|
Zfish    62 IYSLY---FGSKPWVVLNGFEALKEALVTKAVDFAGRPQDLMVNRVTKGG--GVILSDYGPSWKE 121

  Fly   129 QRRFILRHLKNFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVYVLNTLWCM 193
            .|||.|..|:|||..:..|.:.:..|.:.::..|:.:|..:...||.  .|:..|    |.:..:
Zfish   122 HRRFALMTLRNFGLGKQSMEERILGEVSHIIDKLEKRVGTAFDPQTM--FHNAAS----NIICIV 180

  Fly   194 LSGRRYEPGSPEITQLLETFFELF-KNIDMVGA----LFSHFPLLRFIAPNFSGYNGFVESHRSL 253
            |.|.||:...    :.|:.|..|: :|..:...    ::..||:.|::...|..........|.|
Zfish   181 LFGSRYDYDD----EFLKLFIHLYTENAKIANGPWAMIYDTFPMFRYLPLPFRKAFANASKAREL 241

  Fly   254 YTFMSKEIELHRLTYKNYDEPRDLMDSYLRAQDEGNDEKGMFSDQSLLAICLDMFLAGSETTNKS 318
            .|.:.||   |:.|:.. .||||.:|.||...|:..::...||:..|:...||:..||::||:.:
Zfish   242 STQLVKE---HKKTWVP-GEPRDFIDCYLDELDKRGNDGSSFSEAQLILYVLDLHFAGTDTTSNT 302

  Fly   319 LGFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWS-RDRTKLPYCEAITLEAVRMFMLHTFGIPH 382
            |...|::|:..||:|.:..|||.:|  ||...:.| .||..:||.:|:|.|..|:.......:.|
Zfish   303 LLTGFLYLMTHPEVQAKCQQEIDDV--LEDKDQASYEDRHSMPYTQAVTHEVQRVANTVPLSVFH 365

  Fly   383 RAVCDTRLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYLFD-GHLKLPEAFNPFGFGRH 446
            ....||.|.||.|||.|.||......|.....:..|..|||..:|.: |..:.||||.||..|..
Zfish   366 CTTKDTELMGYNIPKGTFVIPNLGSALKEEGQWKFPHEFNPANFLNEQGEFEKPEAFVPFSAGPR 430

  Fly   447 RCMGDLLGRQNLFMFTTTVLQNFKMVAIPGQV--PEEVPLEGATAAVKPYDIMLVARE 502
            .|:|:.|.|..||:...|:|:.|:.| .|...  |:..|:.|.|...:||.:.:..||
Zfish   431 VCLGEGLARMELFLVMVTLLRRFQFV-WPNDAGKPDYTPVYGVTLTPQPYRMHIKRRE 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	140/463 (30%)
cyp2x9	NP_001070921.1	p450	28..479	CDD:278495	144/477 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H111164
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.820