DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp303a1 and Cyp2j9

DIOPT Version :9

Sequence 1:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_083255.1	Gene:	Cyp2j9 / 74519	MGIID:	1921769	Length:	502	Species:	Mus musculus

Alignment Length:	503	Identity:	147/503 - (29%)
Similarity:	246/503 - (48%)	Gaps:	37/503 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VIWIFCATLLAILFGGVRKPKRFPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQYVNPYG 69
            |.::|.|..|.     .|:||.:||||...|.||....:...:..|.:         :|:|..||
Mouse    26 VTFLFLADFLK-----NRRPKNYPPGPMRLPFVGCLFHLDPKQPHLSL---------QQFVKKYG 76

  Fly    70 -FYGLKIGKDKVVIAYTNDAISEMMT--NEDIDGRPDGIFYRLRTFNSRLGVLLTDGEMWVEQRR 131
             ...|.......|:......|.|:.|  ..:...||..:. |...||.. |::.:..:.|.||||
Mouse    77 NVLSLDFANIPSVVITGMPLIKEIFTQMEHNFMNRPVTLL-RKHLFNKN-GLIFSSDQTWKEQRR 139

  Fly   132 FILRHLKNFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVYVLNTLWCMLSG 196
            |.|..|:|||..:..:.:.:..||..|::.::|:    ||:.  .:.|...|..|.|.:..:..|
Mouse   140 FALMTLRNFGLGKRSLEERIQEEAHYLVEAIRDE----GGQP--FDPHFNISNAVSNIICSITFG 198

  Fly   197 RRYEPGSPEITQLLETFFE-LFKNIDMVGALFSHFP-LLRFIAPNFSGYNGFVESHRSLYTFMSK 259
            .|::....:..::|....| :.....|:..|::.|| :|:::.   ..:.....:.|.|..|:|.
Mouse   199 ERFDYHDSQFQEMLRLLDEAMCLESSMMCQLYNIFPRILQYLP---GSHQTLFRNWRKLQLFVSD 260

  Fly   260 EIELHRLTYKNYDEPRDLMDSYLRAQDEGNDE-KGMFSDQSLLAICLDMFLAGSETTNKSLGFCF 323
            .:..||..: :.|||||.:|::|....:..|: ...|::::|:...||:|.||:|||:.:|.:..
Mouse   261 IVNNHRRDW-DPDEPRDFIDAFLTEMTKYPDKTTTSFNEENLICSTLDLFFAGTETTSTTLRWAL 324

  Fly   324 MHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFMLHTFGIPHRAVCDT 388
            :.:.|.||:||:...||..|:|..|.|..: ||..:||..|:..|..||..:..|.:|.....||
Mouse   325 LCMALYPEVQEKMQAEIDRVIGQARQPNLA-DRDSMPYTNAVIHEVQRMGNIIPFNVPREVAVDT 388

  Fly   389 RLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYLFDGHLKLPEAFNPFGFGRHRCMGDLL 453
            :|:|:.:||..||::....:..:|.::..|::|||:.:|.:|..|..|:|.||..|:..|:|:.|
Mouse   389 QLAGFNLPKGIMVLSNLTALHRDPSEWTTPDTFNPEHFLENGQFKKRESFLPFSMGKRACLGEQL 453

  Fly   454 GRQNLFMFTTTVLQNFKMVAIPGQVPEEVPLEGATAA-VKPYDIMLVA 500
            .|..||:|.||:.|.|   .....|.|::.|:...|| |.|....|.|
Mouse   454 ARSELFIFITTLFQKF---TFKPPVNEKLSLQFRMAATVSPVSHRLCA 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	132/457 (29%)
Cyp2j9	NP_083255.1	p450	44..497	CDD:278495	138/477 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820