DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp303a1 and Cyp2s1

DIOPT Version :9

Sequence 1:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_083051.1	Gene:	Cyp2s1 / 74134	MGIID:	1921384	Length:	501	Species:	Mus musculus

Alignment Length:	505	Identity:	136/505 - (26%)
Similarity:	235/505 - (46%)	Gaps:	52/505 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 W-IFCATLLAILFGGV---RKPKR--FPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQYV 65
            | :..|.||.:|...:   |.|.|  .||||...|::|:.||:     |.|.....:...:::|.
Mouse     7 WALLLALLLLLLLLSLTLFRTPARGYLPPGPTPLPLLGNLLQL-----RPGALYSGLLRLSKKYG 66

  Fly    66 NPYGFYGLKIGK-DKVVIAYTNDAISEMMTN--EDIDGRPDGIFYRL-RTFNSRLGVLLTDGEMW 126
            ..:..|   :|. .:||:...:||:.|.:..  |:..||  |....| :||:.. ||...:||.|
Mouse    67 PVFTVY---LGPWRRVVVLVGHDAVREALGGQAEEFSGR--GTLATLDKTFDGH-GVFFANGERW 125

  Fly   127 VEQRRFILRHLKNFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVYVLNTLW 191
            .:.|:|.|..|::.|..:....:::..|    :|.|.:...|:.|:.....|  |.:....|.:.
Mouse   126 KQLRKFTLLALRDLGMGKREGEELIQAE----VQSLVEAFQKTEGRPFNPSM--LLAQATSNVVC 184

  Fly   192 CMLSGRRYEPGSPEITQLLETFFELFKNIDMV-GALFSHFPLLRFIAPNFSGYNGFVESH-RSLY 254
            .::.|.|......|...:::........|... |..:..|..|....|   |.:..::.| .:|.
Mouse   185 SLVFGIRLPYDDKEFQAVIQAASGTLLGISSPWGQAYEMFSWLLQPLP---GPHTQLQHHLGTLA 246

  Fly   255 TFMSKEIELHRLTYKNYDEPRDLMDSYL-----RAQDEGNDEKGMFSDQSLLAICLDMFLAGSET 314
            .|..::::.|:..::.....||::|::|     ..||.|.:    |::::||.....:..||:.|
Mouse   247 AFTIQQVQKHQGRFQTSGPARDVVDAFLLKMAQEKQDPGTE----FTEKNLLMTVTYLLFAGTMT 307

  Fly   315 TNKSLGFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFMLHTFG 379
            ...::.:..:.|:..|::|:|..:|:.:.:|..|.|..| ||.:|||.:|:..||.|:..|...|
Mouse   308 IGATIRYALLLLLRYPQVQQRVREELIQELGPGRAPSLS-DRVRLPYTDAVLHEAQRLLALVPMG 371

  Fly   380 IPHRAVCDTRLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYL-FDGHLKLPEAFNPFGF 443
            :||.....|...||.:||.|.|......:|.:|..|.:|..|:|.|:| .||.|:..|||.|:..
Mouse   372 MPHTITRTTCFRGYTLPKGTEVFPLIGSILHDPAVFQNPGEFHPGRFLDEDGRLRKHEAFLPYSL 436

  Fly   444 GRHRCMGDLLGRQNLFMFTTTVLQNFKMVAIPGQVPEEVPLEGATAAVKP 493
            |:..|:|:.|.|..|::|.|::||.|.:         |.|......::||
Mouse   437 GKRVCLGEGLARAELWLFFTSILQAFSL---------ETPCPPGDLSLKP 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	124/463 (27%)
Cyp2s1	NP_083051.1	p450	50..487	CDD:365848	120/457 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010