DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp303a1 and Cyp2b15

DIOPT Version :9

Sequence 1:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_001129140.1	Gene:	Cyp2b15 / 685222	RGDID:	1596474	Length:	495	Species:	Rattus norvegicus

Alignment Length:	505	Identity:	153/505 - (30%)
Similarity:	251/505 - (49%)	Gaps:	48/505 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 ILFGGVRKPK---RFPPGPAWYPIVGSALQVSQ---LRCRLGMFCKVIDVFARQYVNPYGFYGLK 74
            :|.....:||   ..||||...|.:|:.||:::   ||..:.:..|..|||.           :.
  Rat    17 LLLASQNRPKTHGHLPPGPRPLPFLGNLLQMNRRGLLRSFMQLQEKYGDVFT-----------VH 70

  Fly    75 IGKDKVVIAYTNDAISEMMTN--EDIDGRPDGIFYRLRTFNSRLGVLLTDGEMWVEQRRFILRHL 137
            :|...|||....|.|.|.:.:  |...||  |....|.......||:..:||.|...|||.|..:
  Rat    71 LGPRPVVILCGTDTIREALVDQAEAFSGR--GTVAVLHPVVQGYGVIFANGERWKILRRFSLVTM 133

  Fly   138 KNFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVY---VLNTLWCMLSGRRY 199
            :|||..:..:.:.:..||.||:::||    |..|     .:.:.||::   ..|.:..::.|.|:
  Rat   134 RNFGMGKRSVEERIKEEAQCLVEELK----KYKG-----ALLNPTSIFQSIAANIICSIVFGERF 189

  Fly   200 EPGSPEITQLLETFFELFKNIDMVGALFSH-FPLLRFIAPNFSGYNGFVESH-RSLYTFMSKEIE 262
            :....:..:||:..::.|   .::|:|.|. |.|.......|.|.:..:..: :.:..::...:|
  Rat   190 DYKDHQFLRLLDLIYQTF---SLMGSLSSQVFELFSGFLKYFPGVHKQISKNLQEILNYIDHSVE 251

  Fly   263 LHRLTYKNYDEPRDLMDSY-LRAQDEGNDEKGMFSDQSLLAICLDMFLAGSETTNKSLGFCFMHL 326
            .||.|. :.:.|||.:::| ||.:.|.::....|..|:|:...|.:|..|:|||:.:|.:.|:.:
  Rat   252 KHRATL-DPNTPRDFINTYLLRMEKEKSNHHTEFHHQNLVISVLSLFFTGTETTSTTLRYSFLIM 315

  Fly   327 VLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFMLHTFGIPHRAVCDTRLS 391
            :..|.:.|:..:||.:|:|..|:|... ||||:||.:|:..|..|...|...|:|||...||...
  Rat   316 LKYPHVAEKVQKEIDQVIGSHRLPTLD-DRTKMPYTDAVIHEIQRFADLIPIGLPHRVTNDTMFL 379

  Fly   392 GYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYL-FDGHLKLPEAFNPFGFGRHRCMGDLLGR 455
            ||.:||:|.|.......|.:|..|..|::|||:.:| .:|.||..|||.||..|:..|:|:.:.:
  Rat   380 GYLLPKNTEVYPILSSALHDPRYFDHPDTFNPEHFLDVNGTLKKSEAFLPFSTGKRICLGEGIAQ 444

  Fly   456 QNLFMFTTTVLQNFKMVAIPGQVPEEVPL----EGATAAVKPYDIMLVAR 501
            ..||:|.|.:||||.: |.| ..||::.|    .|.:....||.|..::|
  Rat   445 NELFIFFTAILQNFSL-ASP-VAPEDIDLSPINSGISKIPSPYQIHFLSR 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	142/463 (31%)
Cyp2b15	NP_001129140.1	p450	32..487	CDD:278495	148/483 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820