DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp303a1 and cyp2k8

DIOPT Version :9

Sequence 1:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_001124095.1	Gene:	cyp2k8 / 561462	ZFINID:	ZDB-GENE-080721-19	Length:	507	Species:	Danio rerio

Alignment Length:	501	Identity:	137/501 - (27%)
Similarity:	236/501 - (47%)	Gaps:	62/501 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 PPGPAWYPIVGS--ALQVSQLRCRLGMFCKVIDVFARQYVNPYG-FYGLKIGKDKVVIAYTNDAI 89
            ||||...|::|:  .|.:..|...|....|           .|| .:.:.:|:.|||:......:
Zfish    40 PPGPKPLPLLGNLHTLDLKNLHVSLWELSK-----------KYGPVFKVHLGRKKVVVLAGYKTV 93

  Fly    90 SEMMTNEDIDGRPDGIFYRLRTFNSRLGVLLTDGEMWVEQRRFILRHLKNFGFARSGMMDIVHNE 154
            .:.:.|:..:.....|....:..|...|::..:||.|...|||.|..|::||..:....:.:.:|
Zfish    94 KQALVNQAEEFGERDITPIFQDCNQGQGIVFANGERWRTMRRFALSTLRDFGMGKKLSEEKIVDE 158

  Fly   155 ATCLLQDLKDKVLKSGGKQTRIEMHDLT---SVYVLNTLWCMLSGRRYEPGSPEITQLLETFFEL 216
            .    :.|::..:|..|     :..|.|   :..|.|.:..::.|:|:|...|....::.   :.
Zfish   159 T----RYLREVFMKFEG-----QPFDTTQPVNYAVSNIISAIVYGKRFEYEDPAFQDMVN---KA 211

  Fly   217 FKNIDMVG-ALFSHFPLLRFIAPNFSGYNGFVESHRSLYTFMSKEIELHRLTYK----------N 270
            ..||.|:| |:...:.:..|:.|       ::::.|.|    .|.:|..|...:          |
Zfish   212 NMNIRMIGSAVIQIYNMCPFLGP-------WIKTWRQL----MKNMESTRRQIQTLADVLQETLN 265

  Fly   271 YDEPRDLMDSYL-RAQD--EGNDEKGMFSDQSLLAICLDMFLAGSETTNKSLGFCFMHLVLQPEI 332
            ..:.|.|:||:| |.|:  |..::...|:||:||....::|.||::||..:|.:..|.:...|:|
Zfish   266 PLDCRGLIDSFLIRKQNIQETGEKDSSFNDQNLLITVSNLFAAGTDTTGTTLRWGLMLMAKYPQI 330

  Fly   333 QERAFQEIKEVV-GLERIPEWSRDRTKLPYCEAITLEAVRMFMLHTFGIPHRAVCDTRLSGYEIP 396
            |:|..:||.:|: |.|.:.|   ||..|||.:|:..|..|:..:....:||:..||...:||.|.
Zfish   331 QDRVQEEIDQVLGGREPVAE---DRKNLPYTDAVIHETQRLANILPLNLPHKTSCDVTFNGYFIK 392

  Fly   397 KDTMVIACFRGMLINPVDFPDPESFNPDRYLFD-GHLKLPEAFNPFGFGRHRCMGDLLGRQNLFM 460
            |.|.|:.....:|.:..::..|::|||..:|.: |.|...:||.||..||..|:|:.|.|..||:
Zfish   393 KGTCVLPLLTSVLRDETEWETPDTFNPQHFLDEKGQLIKRDAFMPFSAGRRACLGESLARMELFL 457

  Fly   461 FTTTVLQNFKMVAIPGQVPEEV---PLEGATAAVKPYDIMLVAREQ 503
            |.|::||.|:....||...:|:   |:.|.|....|:.:..|.|.:
Zfish   458 FFTSLLQYFRFSPPPGASEDELDLTPVVGLTLNPSPHKLCAVIRAE 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	130/473 (27%)
cyp2k8	NP_001124095.1	p450	58..497	CDD:278495	128/475 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.910