DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp303a1 and cyp2u1

DIOPT Version :9

Sequence 1:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_001139036.1	Gene:	cyp2u1 / 556280	ZFINID:	ZDB-GENE-070730-1	Length:	533	Species:	Danio rerio

Alignment Length:	490	Identity:	149/490 - (30%)
Similarity:	237/490 - (48%)	Gaps:	51/490 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 PPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQYVNP-------------YG-FYGLKIGKD 78
            ||||..:||||:..........|..|.|....||:...||             || .:.:.:|..
Zfish    44 PPGPKPWPIVGNFGGFLVPPFILKRFVKNSKEFAKVVSNPLSPQAGLIEMSKLYGNIFSIFVGPQ 108

  Fly    79 KVVIAYTNDAISEMMTN--EDIDGRPDGIFYRLRTFNSRLGVLLTD-GEMWVEQRRFILRHLKNF 140
            .:|:....||:.:.|.|  |....||......:.|  .|.|::... |.:|...|||....|::|
Zfish   109 LMVVLTGYDAVRDAMLNHTETFSDRPHIPLVTIIT--KRKGIVFAPYGPLWRTNRRFCHSTLRSF 171

  Fly   141 GFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVYVLNTLWCMLSGRRYEPGSPE 205
            ||.|..:...:|.....:..:|:..:..:|  .:.|::..|.|..|.|.:..|..|:|:.....|
Zfish   172 GFGRMSLEPCIHEGLAIIKTELQSLIETAG--PSGIDLTPLISNAVSNIISLMSLGQRFHHEDKE 234

  Fly   206 ---ITQLLETFFELFKNIDMVGALFSHFPLLRFIAPNFSGYNGFVESHRS---LYTFMSKEIELH 264
               :..|:....|:..|..::  |.:.||.|.::.     :..|.|..|:   :..|:.:.|..|
Zfish   235 FRNMRDLMSHGLEISVNTSIL--LVNVFPWLYYLP-----FGVFKELRRAELDITAFLKRIIARH 292

  Fly   265 RLTYKNYDEPRDLMDSY----LRAQDEGNDEKGMFSDQSLLAICLDMFLAGSETTNKSLGFCFMH 325
            |.|. :.:.|||.:|.|    |..|.||:.|:.:||:..|..|..|:|:||::||..|:.:..::
Zfish   293 RATL-DPENPRDFIDMYLVEMLAKQKEGSSEENLFSEDDLFYIIGDLFIAGTDTTTNSMLWSILY 356

  Fly   326 LVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFMLHTFGIPHRAVCDTRL 390
            :.|.|::||:..:||..|||.||:|..: |::.|||.||..:|.:||.::....|||.|...|..
Zfish   357 MSLYPDVQEKVQKEIDAVVGSERVPSLT-DKSSLPYTEATIMEVIRMTVVVPLSIPHMASETTEF 420

  Fly   391 SGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYLFD-GHLKLPEAFNPFGFGRHRCMGDLLG 454
            .|:.|||.|::|.....:..:|..:.:|:.|||.|:|.| |.:...:.|.|||.||..|||:.|.
Zfish   421 RGFTIPKGTVIIPNLWSVHRDPTVWENPDDFNPSRFLDDQGKILRKDCFIPFGLGRRVCMGEQLA 485

  Fly   455 RQNLFMFTTTVLQNFKMVAIPGQVPEEVPLEGATA 489
            :..||:..|:::|.|..     :.|     |||||
Zfish   486 KMELFLMFTSLMQTFTF-----RFP-----EGATA 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	143/479 (30%)
cyp2u1	NP_001139036.1	p450	44..530	CDD:278495	149/490 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820