DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp303a1 and cyp2aa12

DIOPT Version :9

Sequence 1:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_001103171.2	Gene:	cyp2aa12 / 555510	ZFINID:	ZDB-GENE-071004-47	Length:	501	Species:	Danio rerio

Alignment Length:	501	Identity:	144/501 - (28%)
Similarity:	239/501 - (47%)	Gaps:	66/501 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RFPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQYVNPYG-FYGLKIGKDKVVIAYTNDAI 89
            ||||||...|.||:          :..|.|....|.|. ::.|| ...:.:|:...::..|...|
Zfish    38 RFPPGPTPLPFVGT----------IPHFLKDSMGFIRS-LSQYGEMTTVYLGRKPAMVLNTLQVI 91

  Fly    90 SE--MMTNEDIDGRPD-----------GIFYRLRTFNSRLGVLLTDGEMWVEQRRFILRHLKNFG 141
            .|  :.......|||.           ||            ||.|.|..|.:||||.|..|:|||
Zfish    92 KEAIVQNGTSSSGRPSIPILTWITEGYGI------------VLATFGHSWRQQRRFALHTLRNFG 144

  Fly   142 FARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVYVLNTLWCMLSGRRYEPGSPEI 206
            ..:..:.:.|..|:..|:.::    ||..||... ..|.:.:. |.|.:..::.|.|:|..:...
Zfish   145 LGKKSVEERVTEESGYLVPEM----LKLEGKPFD-PQHAIQNA-VSNIICSIVFGDRFEYDNKRF 203

  Fly   207 TQLLETFFELFKNID----MVGALFSHFPLLRFIAPNFSG-YNGFVESHRSLYTFMSKEIELHRL 266
            ..|||...|   ||:    ::|.:|:..|:::    :|.| :....::...|.:|:.:..:.||.
Zfish   204 EYLLEIIKE---NINQAGSLIGQVFNLIPIIK----HFPGPHQKIYQNAEELKSFIRESTKSHRE 261

  Fly   267 TYKNYDEPRDLMDSY-LRAQDEGNDEKGMFSDQSLLAICLDMFLAGSETTNKSLGFCFMHLVLQP 330
            |. :.|.|||.:|:| |..:.:.:.:...|.:.:::....|:|||||:||..::.:..::|...|
Zfish   262 TL-DPDSPRDFIDAYLLEMEKQKSSQDSSFHEDNMVMSVADLFLAGSDTTATTIRWGLIYLTQNP 325

  Fly   331 EIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFMLHTFGIPHRAVCDTRLSGYEI 395
            ::|||..:||..|:|.:|:| ...||.:|||..|...|..|...:....:||......:|.||:|
Zfish   326 DVQERCHEEIVRVLGYDRLP-CMDDRDRLPYTLATVHELQRCGNIVPSSVPHETTQPMKLRGYDI 389

  Fly   396 PKDTMVIACFRGMLINPVDFPDPESFNPDRYLFD-GHLKLPEAFNPFGFGRHRCMGDLLGRQNLF 459
            |:.|.::.....:|.|...:..|::|||:.:|.| ||...||||.||..|...|:|:.|.:..||
Zfish   390 PQGTQMLINLSDILANKEHWKHPDTFNPENFLDDKGHFYRPEAFLPFSLGPRVCLGETLAKTELF 454

  Fly   460 MFTTTVLQNFKMVAIPGQVPEEVP-LEGATAAVK---PYDIMLVAR 501
            :|.|::||..:.....|   |:.| ::|..:.|:   |:.|:..:|
Zfish   455 LFITSLLQRIRFSWPTG---EKWPNMDGIVSVVRSPEPFKIICHSR 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	135/472 (29%)
cyp2aa12	NP_001103171.2	p450	40..493	CDD:278495	140/493 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820