DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp303a1 and CYP2W1

DIOPT Version :9

Sequence 1:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	XP_011513742.1	Gene:	CYP2W1 / 54905	HGNCID:	20243	Length:	564	Species:	Homo sapiens

Alignment Length:	522	Identity:	140/522 - (26%)
Similarity:	221/522 - (42%)	Gaps:	102/522 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLAILFGGV-----------RKPK---RFPPGPAWYPIVGS--ALQVSQLRCRLGMFCKVIDVFA 61
            ||.:||.|:           :.|.   |:||||...|:||:  .|::||.           |...
Human     3 LLLLLFLGLLGLWGLLCACAQDPSPAARWPPGPRPLPLVGNLHLLRLSQQ-----------DRSL 56

  Fly    62 RQYVNPYG-FYGLKIGKDKVVIAYTNDAISEMMT---NEDIDGRPDGIFYRLRTFNSRLGVLLTD 122
            .:....|| .:.:.:|:.|.|:....:|:.|.:.   .|..|..|..||..::...   |:..:.
Human    57 MELSERYGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQRGG---GIFFSS 118

  Fly   123 GEMWVEQRRFILRHLKNFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVYVL 187
            |..|...|:|.:|.|.:.|..|..:.|.:..|..||...|       .|.:.|.....|......
Human   119 GARWRAARQFTVRALHSLGVGREPVADKILQELKCLSGQL-------DGYRGRPFPLALLGWAPS 176

  Fly   188 NTLWCMLSGRRYEPGSPEITQLLETFFELFKNIDMVGALFSHFPLLRFIAPNFSGYNGFVESHRS 252
            |..:.:|.|||::...|       .|..|...||.|..|..        :|....:|
Human   177 NITFALLFGRRFDYRDP-------VFVSLLGLIDEVMVLLG--------SPGLQLFN-------- 218

  Fly   253 LYTFMSKEIELHRLTYKNYDEPRDLMDSYLRA--------------------QDEGNDEKGMFSD 297
            :|.::...::|||...:..:|.|.::.:.|.|                    |.:|:|.:|:|::
Human   219 VYPWLGALLQLHRPVLRKIEEVRAILRTLLEARRPHVCPGDPVCSYVDALIQQGQGDDPEGLFAE 283

  Fly   298 QSLLAICLDMFLAGSETTNKSLGFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYC 362
            .:.:|..|||.:||:|||:.:|.:..:.:...|::|.|..:|:..|:|..|.|. ..|:..|||.
Human   284 ANAVACTLDMVMAGTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPR-LEDQQALPYT 347

  Fly   363 EAITLEAVRMFMLHTFGIPHRAVC---DTRLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPD 424
            .|:..|..|...|    :||...|   ||:|.|:.:||.|.||.....:|::...:..|..|||.
Human   348 SAVLHEVQRFITL----LPHVPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPG 408

  Fly   425 RYL-FDGHLKLPEAFNPFGFGRHRCMGDLLGRQNLFMFTTTVLQNFKMVAIPGQVPEEVPLEGAT 488
            .:| .:||....|||.||..||..|:|:.|.|..||:....:||:         .|:..|...|.
Human   409 HFLDANGHFVKREAFLPFSAGRRVCVGERLARTELFLLFAGLLQS---------SPQGPPAPTAG 464

  Fly   489 AA 490
            ||
Human   465 AA 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	128/481 (27%)
CYP2W1	XP_011513742.1	p450	32..452	CDD:278495	126/468 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920