DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp303a1 and Cyp2f4

DIOPT Version :9

Sequence 1:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_062176.1	Gene:	Cyp2f4 / 54246	RGDID:	2476	Length:	491	Species:	Rattus norvegicus

Alignment Length:	500	Identity:	131/500 - (26%)
Similarity:	230/500 - (46%)	Gaps:	61/500 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RFPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQYVNPYGFYGLKIGKDKVVIAYTNDAIS 90
            :.||||...||:|:.||:     |.......:...::.|.:.:..|   :|..:|::......:.
  Rat    29 QLPPGPKPLPILGNLLQL-----RSQDLLTSLTKLSKDYGSVFTVY---LGPRRVIVLSGYQTVK 85

  Fly    91 EMMTN--EDIDGRPD-GIFYRLRTFNSRLGVLLTDGEMWVEQRRFILRHLKNFGFARSGMMDIVH 152
            |.:.:  |:..||.. .||:   .|....|:..:|||.|...|||.::.|:|||..:..:.:.:.
  Rat    86 EALVDKGEEFSGRGSYPIFF---NFTKGNGIAFSDGERWKILRRFSVQILRNFGMGKRSIEERIL 147

  Fly   153 NEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVYVL-----NTLWCMLSGRRYEPGSPEITQLLET 212
            .|.:.||    |.:.|:.||       ....|::|     |.:..::.|.|::.....:..::..
  Rat   148 EEGSFLL----DVLRKTEGK-------PFDPVFILSRSVSNIICSVIFGSRFDYDDERLLTIIHF 201

  Fly   213 FFELFKNIDMV-GALFSHFPLL--------RFIAPNFSGYNGFVESHRSLYTFMSKEIELHRLTY 268
            ..:.|:.:... |.:::.||.|        |.:..||.|....:          ::.:..|:.:.
  Rat   202 INDNFQIMSSPWGEMYNIFPSLLDWVPGPHRRVFRNFGGMKDLI----------ARSVREHQDSL 256

  Fly   269 KNYDEPRDLMDSYL-RAQDEGNDEKGMFSDQSLLAICLDMFLAGSETTNKSLGFCFMHLVLQPEI 332
             :.:.|||.:|.:| :...|..|....|:..:||....::...|:||...:|...|:.|:..|::
  Rat   257 -DPNSPRDFIDCFLTKMVQEKQDPLSHFNMDTLLMTTHNLLFGGTETVGTTLRHAFLILMKYPKV 320

  Fly   333 QERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFMLHTFGIPHRAVCDTRLSGYEIPK 397
            |.|..:||..|||..|:|. ..||..:||.:|:..|..|...:....:|||.:.||...|:.|||
  Rat   321 QARVQEEIDCVVGRSRMPT-LEDRASMPYTDAVIHEVQRFADVIPMNLPHRVIRDTPFRGFLIPK 384

  Fly   398 DTMVIACFRGMLINPVDFPDPESFNPDRYLFDGH--LKLPEAFNPFGFGRHRCMGDLLGRQNLFM 460
            .|.||.....:..:...|..|:.|||:.:| |.:  .|...||.||..||..|:|:.|.|..||:
  Rat   385 GTDVITLLNTVHYDSDQFKTPQEFNPEHFL-DANQSFKKSPAFMPFSAGRRLCLGEPLARMELFI 448

  Fly   461 FTTTVLQNFKMVAIPGQVPEEVPLEGATAAV----KPYDIMLVAR 501
            :.|::||||.:  .|...||::.|...::.:    :|:.:.:..|
  Rat   449 YLTSILQNFTL--HPLVEPEDIDLTPLSSGLGNLPRPFQLCMRIR 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	126/471 (27%)
Cyp2f4	NP_062176.1	p450	31..488	CDD:278495	130/493 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920