DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp303a1 and cyp2x6

DIOPT Version :9

Sequence 1:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_001013583.1	Gene:	cyp2x6 / 541440	ZFINID:	ZDB-GENE-050320-144	Length:	491	Species:	Danio rerio

Alignment Length:	510	Identity:	152/510 - (29%)
Similarity:	240/510 - (47%)	Gaps:	38/510 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TVIWIFCATLLAILFGGVRKPKRFPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQYVNPY 68
            :::.:.|..|:..|. .|:|||.|||||...||.||.||::     |....|..:.||.:|...:
Zfish     5 SLLVVICILLIFFLI-RVKKPKNFPPGPPPVPIFGSLLQLN-----LANPLKDFEKFAEKYGEIF 63

  Fly    69 GFYGLKIGKDKVVIAYTNDAISEMMTN--EDIDGRPDGIFYRLRTFNSRLGVLLTD-GEMWVEQR 130
            ..|   .|....||..:...|.|.:..  :|..|||........|.|.  |::|.| |.:....|
Zfish    64 SLY---TGSRPAVILNSFAVIKEALVTKAQDFSGRPQDFMISHATENK--GIVLADYGPVLKGHR 123

  Fly   131 RFILRHLKNFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVYVLNTLWCMLS 195
            ||.|..::|||..:..|.:.:..|    :..:.|.:.|:.||  |::.|.:......|.:..:|.
Zfish   124 RFALMTMRNFGLGKQSMEERILGE----ISHVVDYLDKNAGK--RVDPHIMFHNVASNVISLLLF 182

  Fly   196 GRRYEPGSPEITQLLETFFELFKNIDMV-----GALFSHFPLLRFIAPNFSGYNGFVESHRSLYT 255
            |.|::..|    :.|:.:.:|...|..:     ..::..|||||.:...|......|:..:|:..
Zfish   183 GCRFDYNS----EFLQCYIQLINEISKIINGPWNMIYDTFPLLRILPLPFKKAFDHVKVIKSMNL 243

  Fly   256 FMSKEIELHRLTYKNYDEPRDLMDSYLRAQDEGNDEKGMFSDQSLLAICLDMFLAGSETTNKSLG 320
               |.|:.|:.| :...||||.:|.||...|:|.:....||:..||...:|:..||::|.:.:|.
Zfish   244 ---KLIDEHKST-RVPGEPRDFIDCYLDELDKGKNCVSTFSEDKLLMSIMDLHFAGTDTISNTLL 304

  Fly   321 FCFMHLVLQPEIQERAFQEIKEVV-GLERIPEWSRDRTKLPYCEAITLEAVRMFMLHTFGIPHRA 384
            ..|::|:..||:|.:..|||.:|: |.:|:  ...||..:||..|:..|..|:.......:.|..
Zfish   305 TAFLYLMNHPEVQVKCQQEIDDVLEGKDRV--MYEDRHNMPYTLAVIHEVQRVANTVPLSVFHST 367

  Fly   385 VCDTRLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYLFD-GHLKLPEAFNPFGFGRHRC 448
            ..||.|.||.|||.|::|.....:|.....:..|..|||..:|.: |..:.||||.||..|...|
Zfish   368 TRDTELMGYSIPKGTIIIPNLTRVLKEEGQWKFPYEFNPANFLNEQGQFEKPEAFIPFSTGLRMC 432

  Fly   449 MGDLLGRQNLFMFTTTVLQNFKMV-AIPGQVPEEVPLEGATAAVKPYDIMLVARE 502
            :|:.|.|..||:....:|:.|:.. .:....|:..|:.|.|...|||.:.:..||
Zfish   433 LGEGLARMELFLIFVALLRRFQFEWPVDAGKPDYTPVFGLTLTPKPYRMHIRRRE 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	135/462 (29%)
cyp2x6	NP_001013583.1	p450	36..479	CDD:278495	135/468 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H111164
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.910