DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp303a1 and cyp2aa8

DIOPT Version :9

Sequence 1:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	XP_021325465.1	Gene:	cyp2aa8 / 450060	ZFINID:	ZDB-GENE-041010-183	Length:	499	Species:	Danio rerio

Alignment Length:	478	Identity:	136/478 - (28%)
Similarity:	232/478 - (48%)	Gaps:	59/478 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RFPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQYVNPYGF------YG----LKIGKDKV 80
            ||||||:..|.||:          |.:|.|          ||..|      ||    :.:|:...
Zfish    38 RFPPGPSPLPFVGN----------LPVFLK----------NPMEFIRSLSQYGEMTTIYLGRKPT 82

  Fly    81 VIAYTNDAISEMMTNEDIDGRPDGIFYRLRTFNSRLG-VLLTDGEMWVEQRRFILRHLKNFGFAR 144
            ::..|.....|::..:...|:|.  ...|...::.|| |::|....|.:||||.|..|:|||..|
Zfish    83 IMLNTVQLAKEVLIQDAFAGKPS--LPVLDWVSNGLGIVMVTFNHSWRQQRRFALHTLRNFGLGR 145

  Fly   145 SGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVYVLNTLWCMLSGRRYEPGSPEITQL 209
            ..:...|..|:..|:.:|    ||..||... ..|.|.:.: .|.:..::.|.|::.........
Zfish   146 KSVESRVLEESQYLIAEL----LKKKGKSVN-PHHALQNAF-SNVICSIVFGDRFDYDDKRFEHF 204

  Fly   210 LETFFELFKNIDMVGA----LFSHFPLLRFIAPNFSGYNGFVESHR-SLYTFMSKEIELHRLTYK 269
            ||.   |.|::.:.|:    :|:..|:::    :|.|.:..::.:. .|..|...|::.|:.|.
Zfish   205 LEI---LGKSMILTGSTAGQIFNFAPIIK----HFPGPHQKIKKNADELSGFFQHEVKEHKKTL- 261

  Fly   270 NYDEPRDLMDSYLRAQDEGNDEK-GMFSDQSLLAICLDMFLAGSETTNKSLGFCFMHLVLQPEIQ 333
            :...|||.:|:||...::....| ..|.|::|:....|:|:|||::|..:..:..:.|:..|::|
Zfish   262 DPGSPRDYIDAYLLEMEKQKSNKDSTFHDENLIGSTTDLFVAGSDSTATTFRWGLLFLIQNPDVQ 326

  Fly   334 ERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFMLHTFGIPHRAVCDTRLSGYEIPKD 398
            ||..:||.:|:|.:|:|. ..||.:|||..|...|..|...|..||:.|..:..|:|.||::|:.
Zfish   327 ERCHKEIVQVLGYDRLPS-MEDRDRLPYTLATVHEIQRCANLAPFGLIHETIQPTKLQGYDLPRG 390

  Fly   399 TMVIACFRGMLINPVDFPDPESFNPDRYLFD-GHLKLPEAFNPFGFGRHRCMGDLLGRQNLFMFT 462
            |.:|.....:..|..::..|::|||:.:|.: |.....|:|.||..|...|:|:.|.|..||:|.
Zfish   391 TTIIVNLTAIFSNKENWKHPDTFNPENFLDESGQFSKHESFIPFSLGVRVCLGETLARTELFLFI 455

  Fly   463 TTVLQNFKMVAIPGQVPEEVPLE 485
            |.:||..:. ::|   |:..|::
Zfish   456 TALLQRIRF-SLP---PDAKPMD 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	132/469 (28%)
cyp2aa8	XP_021325465.1	p450	40..491	CDD:306555	134/476 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820