DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp303a1 and cyp2k16

DIOPT Version :9

Sequence 1:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_001005963.2	Gene:	cyp2k16 / 449790	ZFINID:	ZDB-GENE-041010-37	Length:	502	Species:	Danio rerio

Alignment Length:	504	Identity:	141/504 - (27%)
Similarity:	244/504 - (48%)	Gaps:	54/504 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TVIWIFCATLLA-ILFGGVRKPKRFPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQYVNP 67
            |:|......|:| :||...:..:..||||...|::|:.|.:...:..|.: |::    |:|:...
Zfish    15 TLICFLLLLLVAYLLFLRSQSDENEPPGPKPLPLLGNLLMLDVNKPHLSL-CEM----AKQFGPV 74

  Fly    68 YGFYGLKIGKDKVVIAYTNDAISEMMTN--EDIDGRPDGIFYRLRTFNSRLGVLLTDGEMWVEQR 130
            :..|   .|..|||:.....|:.:.:.|  |....|.  |......|....|::..:||.|.|.|
Zfish    75 FKVY---FGPKKVVVLAGYKAVKQALVNYAEAFGDRE--IMPLFHDFTKGHGIIFANGESWREMR 134

  Fly   131 RFILRHLKNFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVYVLNTLWCMLS 195
            ||.|.:|::||..:..:.:.:..| ||   .|:::..|..||.  .|...|.:....:.:..::.
Zfish   135 RFALTNLRDFGMGKKKIEEKIIEE-TC---HLREEFEKFEGKP--FETAQLMNYAASSVISSIVY 193

  Fly   196 GRRYEPGSPEITQLLETFFELFKNIDMVGA----LFSHFPLLRFIAPNFSGYNGFVESHRSLYTF 256
            |||:|...|::..:::...|   ::.:.|:    |::.||   |:.|       .:::.|.|...
Zfish   194 GRRFEYTDPQLRTMVDRANE---SVRLSGSASVQLYNMFP---FLGP-------LLKNWRQLMKN 245

  Fly   257 MSKEIE--------LHRLTYKNYDEPRDLMDSYL----RAQDEGNDEKGMFSDQSLLAICLDMFL 309
            :..:||        ||:..  |:.:.|..:||:|    .|:|.| ::...|.:|:|:....::|:
Zfish   246 LHLDIEEISELVNGLHQTL--NHQDLRGFVDSFLVRKQYAEDSG-EKDSHFHEQNLIYTVGNLFV 307

  Fly   310 AGSETTNKSLGFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFM 374
            ||::||:.:|.:..:.:...|.||:|..:||.:|:| .|.|. |.||..|||.:|:..|..|:..
Zfish   308 AGTDTTSTTLRWSLLLMAKYPHIQDRVQEEIDQVIG-GRQPV-SEDRKNLPYTDAVIHETQRLAN 370

  Fly   375 LHTFGIPHRAVCDTRLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYLFD-GHLKLPEAF 438
            :....|||....|...:||.|.|.|.:......:|.:..::..|..|||:.:|.: |.....:||
Zfish   371 IVPMSIPHMTSSDITFNGYFIKKGTCIFPLLTSVLWDEDEWETPHIFNPNHFLDEQGRFVKRDAF 435

  Fly   439 NPFGFGRHRCMGDLLGRQNLFMFTTTVLQNFKMVAIPGQVPEEVPLEGA 487
            .||..||..|:|:.|.|..||:|.|::||.|:....||...:|:.|..|
Zfish   436 MPFSAGRRICLGESLARMELFLFFTSLLQYFRFTPPPGVSEDELELTPA 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	132/470 (28%)
cyp2k16	NP_001005963.2	p450	58..497	CDD:278495	128/461 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.910