DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp303a1 and cyp2x8

DIOPT Version :9

Sequence 1:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_001002187.1	Gene:	cyp2x8 / 431734	ZFINID:	ZDB-GENE-040704-28	Length:	451	Species:	Danio rerio

Alignment Length:	457	Identity:	136/457 - (29%)
Similarity:	214/457 - (46%)	Gaps:	49/457 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TVIWIFCATLLAILFGGVRKPKRFPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQYVNPY 68
            :|:.:.| .||..|...:::||.|||||:..||.|:.|..:     |....|..:.||.:|.|.:
Zfish     5 SVLVLIC-ILLVFLLIRIQRPKNFPPGPSPLPIFGNLLHFN-----LANPLKDFERFAEKYGNIF 63

  Fly    69 GFYGLKIGKDKVVIAYTNDAISEMMTN--EDIDGRPDGIFYRLRTFNSRLGVLLTD-GEMWVEQR 130
            ..|   .|....|...:...|.|.:..  :|..|||..  :.:.......||:|.| |.:|.:.|
Zfish    64 SLY---TGSRPAVFLNSFAVIKEALVTKAQDFSGRPQD--FMISHLTECKGVVLADYGPLWKDHR 123

  Fly   131 RFILRHLKNFGFARSGMMDIVHNE---ATCLLQDLKDKVLKSGGK--QTRIEMHDLTSVYVLNTL 190
            ||.|..|:|||..:..|.:.:..|   ..|.|.       |:.||  ..::..|::.|    |.:
Zfish   124 RFALMTLRNFGLGKQSMEERILGEISHVVCYLD-------KNIGKTVDPQVMFHNVAS----NVI 177

  Fly   191 WCMLSGRRYEPGSPEITQLLETFFELFKNIDMV-----GALFSHFPLLRFIAPNFSGYNGFVESH 250
            ..:|.|||::..|    :.|:.:.:|...|..:     ..::...|.||.:...|.  .||  .|
Zfish   178 SLVLFGRRFDYNS----ETLQCYIQLITEISKILNGPWNMIYDTLPFLRILPLPFK--KGF--DH 234

  Fly   251 RSLYTFMS-KEIELHRLTYKNYDEPRDLMDSYLRAQDEGNDEKGMFSDQSLLAICLDMFLAGSET 314
            ..:...|: |.|:.|:.| :...:|||.:|.||...|:..:|...||:..||...||::.||::|
Zfish   235 VKVLKGMNLKLIDEHKST-RVPGKPRDFIDCYLDELDKRKNEVSTFSEDQLLMYILDLYFAGTDT 298

  Fly   315 TNKSLGFCFMHLVLQPEIQERAFQEIKEVV-GLERIPEWSRDRTKLPYCEAITLEAVRMFMLHTF 378
            |:.:|...|::|:..||:|.:..|||.:|: |.:::.  ..||..:||..|:..|..|:......
Zfish   299 TSNTLLTAFLYLMNHPEVQVKCQQEIDDVLEGKDQVS--YEDRDNMPYTLAVIHEVQRVANTVPL 361

  Fly   379 GIPHRAVCDTRLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYLFD-GHLKLPEAFNPFG 442
            .:.|....||.|.||.|||.|::|.....:|.....:..|..|||..:|.: |..:.||||.||.
Zfish   362 SVFHCTTRDTELMGYSIPKGTLIIPNLTIVLKEEGQWKFPHEFNPANFLNEQGQFEKPEAFIPFS 426

  Fly   443 FG 444
            .|
Zfish   427 TG 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	128/433 (30%)
cyp2x8	NP_001002187.1	p450	28..428	CDD:278495	127/431 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H111164
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820