DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp303a1 and cyp2p9

DIOPT Version :9

Sequence 1:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_956914.1	Gene:	cyp2p9 / 393592	ZFINID:	ZDB-GENE-040120-2	Length:	496	Species:	Danio rerio

Alignment Length:	518	Identity:	144/518 - (27%)
Similarity:	240/518 - (46%)	Gaps:	53/518 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 WIFCATLLA-----ILFGGVRK---PKRFPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQ 63
            ||...::|.     :|.|...|   ||.|||||...||:|....:...:..| .|.|    ||.:
Zfish     9 WIDIKSILIFLCVFLLLGDYIKNKAPKNFPPGPWSLPIIGDLHHIDNSKIHL-QFTK----FAER 68

  Fly    64 YVNPYGFYGLKIGKDKVVIAYTNDAISE--MMTNEDIDGRPD-GIFYRLRTFNSRLGVLLTDGEM 125
            |.|   .:.|::...::|:....:.:.|  :...:::..||. .:||.:   ....|::|:.|..
Zfish    69 YGN---IFSLRLFGPRIVVLNGYNLVKEVYIKQGDNLADRPVLPLFYEI---IGDKGIVLSSGYK 127

  Fly   126 WVEQRRFILRHLKNFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGK--QTRIEMHDLTSVYVLN 188
            |..||||.|..|:|||..:..:...::.|...    |.:.:....|:  ..|:.:::..|    |
Zfish   128 WKHQRRFALSTLRNFGLGKKSLEPSINLECGF----LNEAISNEQGQPFDPRLLLNNAVS----N 184

  Fly   189 TLWCMLSGRRYEPGSPEITQLLETFFE-LFKNIDMVGALFSHFPLLRFIAPNFSGYNGFVESHRS 252
            .:..::.|.|::........||:...| ::....:...|::.||.|....|.         ||:.
Zfish   185 VICVLVFGNRFDYSDHHFQTLLKHINEAIYLEGGICAQLYNMFPWLMQRLPG---------SHKK 240

  Fly   253 LYT-------FMSKEIELHRLTYKNYDEPRDLMDSYLRAQDEGNDEKGMFSDQSLLAIC-LDMFL 309
            :.|       |:.:::..||:.:...: |||.:|.:|...|:..|:.....|...|.|| ||:|:
Zfish   241 VITLWKKVIDFIRQKVNEHRVDHDPLN-PRDYIDCFLAEMDKLKDDTAAGFDVENLCICTLDLFV 304

  Fly   310 AGSETTNKSLGFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFM 374
            ||:|||:.:|.:..::::..|.||.:..:||..|||..|.|..| ||..:||..|:..|..||..
Zfish   305 AGTETTSTTLYWGLLYMMKYPGIQAKVQEEIDRVVGGSRQPSVS-DRDNMPYTNAVIHEIQRMGN 368

  Fly   375 LHTFGIPHRAVCDTRLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYL-FDGHLKLPEAF 438
            :....:......|.|:..|.:||.|||.:....:|.:..::..|.||||..:| .:|..:..:||
Zfish   369 IIPINVTRTTSEDIRIGKYSVPKGTMVTSNLTSVLFDESEWETPHSFNPGHFLDAEGKFRRRDAF 433

  Fly   439 NPFGFGRHRCMGDLLGRQNLFMFTTTVLQNFKMVAIPGQVPEEVPLEGATAAVKPYDIMLVAR 501
            .||..|:..|:|:.|.|..||:|.:::||.|......|..|......|||...:||.:..|.|
Zfish   434 LPFSLGKRVCLGEQLARMELFLFFSSLLQRFTFSPPAGVEPSLDYKLGATHCPQPYQLCAVPR 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	127/466 (27%)
cyp2p9	NP_956914.1	p450	38..492	CDD:278495	133/483 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820