DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp303a1 and cyp2k18

DIOPT Version :9

Sequence 1:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	XP_005163790.1	Gene:	cyp2k18 / 393484	ZFINID:	ZDB-GENE-040426-1584	Length:	503	Species:	Danio rerio

Alignment Length:	517	Identity:	143/517 - (27%)
Similarity:	245/517 - (47%)	Gaps:	58/517 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 IFCATLLAILFGGVRKPKRFPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVF---ARQYVNPYG 69
            :|....|.....|.:|..:.||||...|::|:.|.:...|        ..|.|   ::.|.|.:.
Zfish    22 LFLVLYLVSSGSGSQKEGKEPPGPKPLPLLGNLLTLDLTR--------AFDTFFELSKTYGNIFQ 78

  Fly    70 FYGLKIGKDKVVIAYTNDAISEMMTN--EDIDGRPDGIFYRLRTFNSRLGVLLTDGEMWVEQRRF 132
            .|   :|..|.|:......:.|.:.|  |....|..|..:|:  .|...|::.::||.|.|.|||
Zfish    79 VY---LGPKKTVVLVGYKTVKEALVNHAEAFGDREIGPSFRI--MNDEHGIVFSNGENWKEMRRF 138

  Fly   133 ILRHLKNFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVYVLNTLWCMLSGR 197
            .|.:|::||..:.|..:.:..|    :..||.:..|..||.  .:..:..:..|.|.:..::.|.
Zfish   139 ALSNLRDFGMGKRGSEEKIIEE----IHHLKGEFDKFEGKP--FDTTEPVNYAVSNIISSIVYGS 197

  Fly   198 RYEPGSPEITQLLETFFELFKNIDMVGA----LFSHFPLL-------RFIAPNFSGYNGFVESHR 251
            |:|...|:.|::::...|   |:.:.|:    |::.||.|       |.:..|      .::|..
Zfish   198 RFEYTDPQFTEMVDRANE---NVRVGGSISMGLYNMFPWLGPFLKNKRIVVRN------IIQSRA 253

  Fly   252 SLYTFMSKEIELHRLTYKNYDEPRDLMDSYL--RAQDEGNDEK-GMFSDQSLLAICLDMFLAGSE 313
            .:...::..:|.     .|.::||..:||:|  :..||.:.:| ..|.:::|:....::|:||::
Zfish   254 QMTKLITALLET-----LNPNDPRGFVDSFLIHKLSDEKSGKKNSYFHNENLMMNVANLFVAGTD 313

  Fly   314 TTNKSLGFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFMLHTF 378
            ||..:|.:..|.:...|:||:|..:||..|:| .|.|. ..||.||||.:|:..|..|...:...
Zfish   314 TTGTTLRWGLMLMAKYPQIQDRVQEEIDRVIG-GRQPA-VEDRKKLPYTDAVIHEIQRFANIVPL 376

  Fly   379 GIPHRAVCDTRLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYLFD-GHLKLPEAFNPFG 442
            .:||...||...:||.|.|.|.||.....:|.:..::..|.||.|:.:|.: |.....:||.||.
Zfish   377 NLPHTTSCDITFNGYFIKKGTTVIPLLTSVLKDESEWEKPNSFYPEHFLDEKGQFVKRDAFMPFS 441

  Fly   443 FGRHRCMGDLLGRQNLFMFTTTVLQNFKMVAIPGQVPEEVPLE---GATAAVKPYDIMLVAR 501
            .||..|:|:.|.|..||:|.|::||:::....||...:|:.|:   |.|....|:.:..:.|
Zfish   442 AGRRICLGESLARMELFLFFTSLLQSYRFTTPPGVSEDELDLKGIVGITLNPSPHKLCAIRR 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	133/471 (28%)
cyp2k18	XP_005163790.1	p450	63..499	CDD:278495	130/462 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.910