DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp303a1 and cyp2k22

DIOPT Version :9

Sequence 1:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_956529.1	Gene:	cyp2k22 / 393204	ZFINID:	ZDB-GENE-040426-822	Length:	503	Species:	Danio rerio

Alignment Length:	519	Identity:	145/519 - (27%)
Similarity:	252/519 - (48%)	Gaps:	49/519 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 YTVIWIFCATLLAIL---FGGVRKPKRFPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQY 64
            :||..:....||.::   |...:...::||||...|::|: |.:..|:.......|:    ::||
Zfish    13 FTVGMVVAFLLLFLVISYFSSSKDQGKYPPGPKPLPLLGN-LHILDLKNTYMSLWKL----SKQY 72

  Fly    65 VNPYGFYGLKIGKDKVVIAYTNDAISEMMTN--EDIDGRP-DGIFYRLRTFNSRLGVLLTDGEMW 126
             .|  .|.:.:|...||:.....|:.|.:.|  |:...|. ..||   :.||...|::.::||.|
Zfish    73 -GP--VYTVHMGPRTVVVLSGYKAVKEALVNLSEEFGERDISPIF---QDFNEGYGIVFSNGENW 131

  Fly   127 VEQRRFILRHLKNFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGK--QTRIEMHDLTSVYVLNT 189
            .|.|||.|.:|::||..:....:::..|    ::.||:::.:.|||  :|::.:    ::.:.|.
Zfish   132 KEMRRFALSNLRDFGMGKKRGEELITEE----IKYLKEEIERFGGKPFETKLPL----AMAISNV 188

  Fly   190 LWCMLSGRRYEPGSPEITQLLETFFELFKNIDMVGA----LFSHFPLLRFIAPNFSGYNGFVESH 250
            :..::...|:|..||:..:.:....|   |..:||:    |::.||.||....|   ....|::.
Zfish   189 IALIVYSIRFEYNSPKFHRAIVRANE---NAKLVGSPSVQLYNMFPWLRLFVIN---QKRVVDNV 247

  Fly   251 RSLYTFMSKEIELHRLTYKNYDEPRDLMDSYLRAQDEGNDEKG----MFSDQSLLAICLDMFLAG 311
            :..:..:.:.:...:.|. |...||.:.|.:| .|.:.:.|.|    :::..:.|....::|.||
Zfish   248 QESFKQIGEIVNGLKKTL-NPQSPRGIADKFL-IQQQKDKESGKTDSLYNSNNFLTTINNLFGAG 310

  Fly   312 SETTNKSLGFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFMLH 376
            .:||..:|.:..:.:...||||.:...||..|:| ||.|. ..||..|||.:|:..|..|...:.
Zfish   311 IDTTVTTLRWGLLLIAKYPEIQAKVHDEIDSVIG-ERQPV-PGDRKNLPYTDAVIHEIQRFADIL 373

  Fly   377 TFGIPHRAVCDTRLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYL-FDGHLKLPEAFNP 440
            ..|:..:..||..|:||.|.|.|.|......:|.:..::..|:||||..:| ..|.....:||.|
Zfish   374 PIGLLRQTSCDVHLNGYLIKKGTSVFPLIASVLRDENEWETPDSFNPKHFLNKQGQFVKKDAFMP 438

  Fly   441 FGFGRHRCMGDLLGRQNLFMFTTTVLQNFKMVAIPGQVPEEV---PLEGATAAVKPYDIMLVAR 501
            ||.||..|:|:.|.|..||:|.|::||:|.....||...:|:   |:.|.|.:..|:.:..|.|
Zfish   439 FGAGRRLCIGESLARMELFLFFTSLLQHFCFTPPPGVSEDELDLTPVVGFTLSPMPHKLCAVKR 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	133/465 (29%)
cyp2k22	NP_956529.1	p450	62..498	CDD:278495	130/463 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.010